Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gwendolyn, Swarbrick"'
Autor:
Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David I. Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Human lung-resident MAIT cells are distinct from CD8+ T cells. They are polycytotoxic, secrete the directly antimicrobial molecule IL-26, express genes associated with persistence, and selectively express interferon-γ- and IL-12- receptors.
Externí odkaz:
https://doaj.org/article/d3ef35794a73444aa9aa0c8fe8dffb79
Autor:
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D. Null, Meghan Cansler, Harriet Mayanja-Kizza, W. Henry Boom, Phalkun Chheng, Melissa R. Nyendak, David M. Lewinsohn, Deborah A. Lewinsohn, Christina L. Lancioni
Publikováno v:
Pathogens, Vol 12, Iss 11, p 1353 (2023)
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient host immuni
Externí odkaz:
https://doaj.org/article/cebbe528c24541dfa889784b98a9c952
HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells
Autor:
Melanie J. Harriff, Lisa M. Wolfe, Gwendolyn Swarbrick, Megan Null, Meghan E. Cansler, Elizabeth T. Canfield, Todd Vogt, Katelynne Gardner Toren, Wei Li, Mary Jackson, Deborah A. Lewinsohn, Karen M. Dobos, David M. Lewinsohn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8+ T cells are important to the control of Mtb infection. W
Externí odkaz:
https://doaj.org/article/bc18a49d1954428b9bb82c6c9deb9699
Autor:
Erin W, Meermeier, Christina L, Zheng, Jessica G, Tran, Shogo, Soma, Aneta H, Worley, David I, Weiss, Robert L, Modlin, Gwendolyn, Swarbrick, Elham, Karamooz, Sharon, Khuzwayo, Emily B, Wong, Marielle C, Gold, David M, Lewinsohn
Publikováno v:
Communications biology. 5(1)
Mucosal-associated Invariant T (MAIT) cells are an innate-like T cell subset that recognize a broad array of microbial pathogens, including respiratory pathogens. Here we investigate the transcriptional profile of MAIT cells localized to the human lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82c8848250263f86933eedcac2f058c6
https://pubmed.ncbi.nlm.nih.gov/36085311
https://pubmed.ncbi.nlm.nih.gov/36085311
Autor:
Christina Lancioni, Erin Morrow, Qijia Liu, Gwendolyn Swarbrick, Sarah Kiguli, Mary Nsereko, Megan Toerien, Meghan Cansler, David Michael Lewinsohn, Deborah Lewinsohn
Publikováno v:
The Journal of Immunology. 208:161.19-161.19
T cells from young children may be limited in capacity to mount pro-inflammatory responses to intracellular pathogens, thus contributing to vulnerability to TB disease. We compared CD4+ and CD8+ T cell cytokine production in response to mycobacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c24b88b995d243cffeae1dd308006218
https://doi.org/10.4049/jimmunol.208.supp.161.19
https://doi.org/10.4049/jimmunol.208.supp.161.19
Autor:
Melissa R Nyendak, Byung Park, Megan D Null, Joy Baseke, Gwendolyn Swarbrick, Harriet Mayanja-Kizza, Mary Nsereko, Denise F Johnson, Phineas Gitta, Alphonse Okwera, Stefan Goldberg, Lorna Bozeman, John L Johnson, W Henry Boom, Deborah A Lewinsohn, David M Lewinsohn, Tuberculosis Research Unit and the Tuberculosis Trials Consortium
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81564 (2013)
RATIONALE:Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium tuberculosis (Mtb) specific CD8(+) T cells, by virtue of detecting intracellular infection,
Externí odkaz:
https://doaj.org/article/3f1e8df2bfa044d58cd5140c888c64a6
Autor:
Meghan E. Cansler, Guanming Wu, David R. Sherman, Keith A. Chervenak, Kristi Guinn, W. Henry Boom, Deborah A. Lewinsohn, Shannon K. McWeeney, David M. Lewinsohn, Tomi Mori, Byung Park, LaShaunda L. Malone, Melissa Nyendak, Harriet Mayanja-Kizza, Sarah Zalwango, Gwendolyn Swarbrick, Joy Baseke, Katelynne Gardner Toren, Megan D. Null
Publikováno v:
npj Vaccines, Vol 2, Iss 1, Pp 1-11 (2017)
NPJ Vaccines
NPJ Vaccines
Despite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfca46013af284a68ab10494f7c5f28
https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba1
https://doaj.org/article/6a7fcb5a9dd24cd682d8a9c35d006ba1
Autor:
James E. McLaren, Kristin Ladell, Gwendolyn Swarbrick, Erin W. Meermeier, David Price, Gitanjali A. Narayanan, Jessica Tran, Todd M. Vogt, Aneta H. Worley, David M. Lewinsohn, Emily B. Wong
Publikováno v:
Immunol Cell Biol
Mucosal-associated invariant T (MAIT) cells are key players in the immune response against microbial infection. The MAIT T-cell receptor (TCR) recognizes a diverse array of microbial ligands, and recent reports have highlighted the variability in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50509ac1a5538760cda6ce188ef01d21
https://pubmed.ncbi.nlm.nih.gov/32568415
https://pubmed.ncbi.nlm.nih.gov/32568415
Autor:
James E. McLaren, Kristin Ladell, Gwendolyn Swarbrick, David Price, Joseph A. Reistetter, Ted H. Hansen, Ole Lund, Deborah A. Lewinsohn, Morten Nielsen, David M. Lewinsohn, Yik Y. L. Yu, Marielle C. Gold, Sue Smyk-Pearson
Publikováno v:
Molecular Immunology. 68:133-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b7f2d33da27a003a0ef58fcdbda2547
https://doi.org/10.1016/j.molimm.2014.04.002
https://doi.org/10.1016/j.molimm.2014.04.002
Autor:
Gwendolyn Swarbrick, Meghan E. Cansler, Jenny Howard, Jeffrey Boyle, Hiam Salim, Nadia Pc. Allen, Megan Null, David M. Lewinsohn, Deborah A. Lewinsohn, Misato Miyamasu
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 113
The new generation of the IGRA QuantiFERON-TB Gold Plus (QFT-Plus) includes two antigen tubes, TB1 and TB2 which contain specific Mycobacterium tuberculosis peptides designed to stimulate both CD4 and CD8 T-cells. TB1 is designed to target cell media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7696bc575e357d18a717e1539354c25
https://pubmed.ncbi.nlm.nih.gov/30514508
https://pubmed.ncbi.nlm.nih.gov/30514508