Výsledky vyhledávání - "Gwenaelle Carn"

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

Autor: Jean-René Kiechel, Laurent A. Decosterd, Bernhards Ogutu, Chantal Csajka, Monia Guidi, Gwenaelle Carn, Manel Aouri, Thomas Mercier

Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-14 (2019)
Malaria Journal
Malaria journal, vol. 18, no. 1, pp. 139

Background The World Health Organization (WHO) recommends combinations of an artemisinin derivative plus an anti-malarial drug of longer half-life as treatment options for uncomplicated Plasmodium falciparum infections. In Africa, artesunate–mefloq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797ef1fb2baf21363b0463ad66a31894
https://doi.org/10.1186/s12936-019-2754-6

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Population Pharmacokinetics and Pharmacodynamic Considerations of Amodiaquine and Desethylamodiaquine in Kenyan Adults with Uncomplicated Malaria Receiving Artesunate-Amodiaquine Combination Therapy

Autor: Charles O Obonyo, Jean-René Kiechel, Gwenaelle Carn, Elizabeth Juma, Bernhards Ogutu, Vincent Jullien

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:2611-2617

Amodiaquine (AQ) is an antimalarial drug that was frequently combined with artesunate (AS) for the treatment of uncomplicated malaria due to Plasmodium falciparum and is now available as a fixed-dose combination. Despite its widespread use, the simul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08b273fcb9d5e3af3eb3f5c8d43d4d
https://doi.org/10.1128/aac.01496-09

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Fixed dose artesunate amodiaquine – a phase IIb, randomized comparative trial with non-fixed artesunate amodiaquine

Autor: Gwenaelle Carn, Michel Vaillant, Elizabeth Juma, Charles O Obonyo, Bernhards Ogutu, Walter R. J. Taylor, Jean-René Kiechel, Vincent Jullien

Publikováno v: Malaria Journal, Vol. 13, No 1 (2014) P. 498
Malaria Journal

Background Pharmacokinetic (PK) and pharmacodynamic (PD) data are limited for artesunate (AS) and amodiaquine (AQ) in uncomplicated Plasmodium falciparum. Methods From 2007-8, 54 P. falciparum-infected, Kenyan adults were assigned randomly fixed dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba19c8f5adda72bf316e561cd84466be
https://archive-ouverte.unige.ch/unige:83227

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Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

Autor: Anna Benet-Pagès, Bettina Lorenz-Depiereux, Gwenaelle Carn, Tim M. Strom, Kenneth E. White, Michael J. Econs

Publikováno v: Kidney International. 60(6):2079-2086

Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Background The gene for the renal phosphate wasting disorder autosomal-dominant hypophosphatemic rickets (ADHR) is FGF23 , which encodes a secreted protein related to the

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Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial

Autor: Pascal Houzé, Parastou Valeh, Philippe J Guerin, Timothy Sundaygar, Jean-René Kiechel, Gwenaelle Carn, Eric Comte, Richard G. Smith, Elizabeth A. Ashley, Yah Zolia, Loretxu Pinoges, Joel J. Jones, Elisabeth Baudin, Birgit Schramm, Charles S Mazinda, Mehul Dhorda, Vincent Jullien, Yap Boum

Publikováno v: Malaria Journal
Malaria Journal, 2013, 12 (1), pp.251. ⟨10.1186/1475-2875-12-251⟩
Malaria Journal, BioMed Central, 2013, 12 (1), pp.251. ⟨10.1186/1475-2875-12-251⟩
Malaria Journal, BioMed Central, 2013, 12 (1), pp.251. 〈10.1186/1475-2875-12-251〉

Prospective efficacy monitoring of anti-malarial treatments is imperative for timely detection of resistance development. The in vivo efficacy of artesunate-amodiaquine (ASAQ) fixed-dose combination (FDC) was compared to that of artemether-lumefantri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8ecb1b6e7ca9b50c26217d55caad0e
https://www.hal.inserm.fr/inserm-00903747/document

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Physical map of theHLA-A/HLA-F subregion and identification of two new coding sequences

Autor: J. LeGall, Gwenaelle Carn, Abdel El Kahloun, Bruno Chauvel, Pascale Bouric, Thierry Giffon, Laurent Pichon, Véronique David

Publikováno v: Immunogenetics. 43:175-181

As part of an effort to characterize the hemochromatosis gene, we selected three non-chimeric yeast artificial chromosomes (YACs) overlapping with the YAC B30 previously described and forming an 800 kilobase contig covering the HLA-A/HLA-F region. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea043567f32afd0bf4c9d35d4b31549
https://doi.org/10.1007/bf00587297

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Structural Analysis of the HLA-A/HLA-F Subregion: Precise Localization of Two New Multigene Families Closely Associated with the HLA Class I Sequences

Autor: Bruno Chauvel, Jean-Yves Legall, Pascale Bouric, Thierry Giffon, Gwenaelle Carn, Véronique David, Maïna Lepourcelet, Laurent Pichon, Jean Mosser

Publikováno v: Genomics. 32:236-244

Positional cloning strategies for the hemochromatosis gene have previously concentrated on a target area restricted to a maximum genomic expanse of 400 kb around the HLA-A and HLA-F loci. Recently, the candidate region has been extended to 2-3 Mb on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1e3fa9c3e6e0ebb1751416784e18ef
https://doi.org/10.1006/geno.1996.0110

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Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II

Autor: Kenneth E. White, Michelle L. Johnson, Maureen Kocisko, Tatiana Foroud, Michael J. Econs, Steven G. Waguespack, Gwenaelle Carn, Tonya Fishburn, Kenneth A. Buckwalter, Wayne E. Evans, Daniel L. Koller

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 18(8)

ADO2 is an uncommon sclerosing bone disorder with incomplete penetrance and variable expressivity. Positional candidate studies were performed to identify the gene responsible for ADO2. In 11 of 12 kindreds, five different missense mutations were ide

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https://pubmed.ncbi.nlm.nih.gov/12929941

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Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13

Autor: Munro Peacock, Michael J. Econs, Tatiana Foroud, Siu L. Hui, P. Michael Conneally, C. Conrad Johnston, Wayne E. Evans, Daniel L. Koller, Gwenaelle Carn

Publikováno v: The Journal of clinical endocrinology and metabolism. 87(8)

A major determinant of the risk of osteoporosis is peak bone mineral density (BMD), which has been shown to have substantial heritability. The genes for 3 BMD-related phenotypes (autosomal dominant high bone mass, autosomal recessive osteoporosis-pse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1845dae03c42c74b1ae28b441ead68b
https://pubmed.ncbi.nlm.nih.gov/12161516

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