Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gwenaelle Bouscary-Desforges"'
Autor:
John Kallikat Augustine, Anna Quattropani, Gwenaelle Bouscary-Desforges, Gérald Bernardinelli, Agnes Bombrun
Publikováno v:
ChemInform. 43
Treatment of the uracil (I) with the acrylates (II) followed by cyclization and chlorination provides an efficient approach to 2,4,8-trichloropyridopyrimidines.
Autor:
Anna Quattropani, Agnes Bombrun, Gérald Bernardinelli, Gwenaelle Bouscary-Desforges, John Kallikat Augustine
Publikováno v:
ChemInform. 43
The use of appropriate conditions and reagents allows regioselective formation of a number of differently substituted pyridopyrimidines.
Autor:
Anna Quattropani, Agnes Bombrun, Gérald Bernardinelli, John Kallikat Augustine, Gwenaelle Bouscary-Desforges
Publikováno v:
The Journal of organic chemistry. 77(10)
We report herein an efficient route for the synthesis of 2,4,8-trichloropyrido[3,2-d]pyrimidines 1 with R(1) substituents at C-6. The potential of such scaffolds was demonstrated by the possibility to displace regioselectively each aromatic chloride
Autor:
Gwenaelle Bouscary-Desforges, John Kallikat Augustine, Gérald Bernardinelli, Agnes Bombrun, Anna Quattropani
Publikováno v:
The Journal of organic chemistry. 77(1)
We report herein the synthesis of 4-amino-2,8-dichloropyrido[3,2-d]pyrimidine derivatives 2 and their regioselective diversification through S(N)Ar and metal-catalyzed cross-coupling reactions. While amination of 2 took place selectively at C-2, the
Autor:
Gordon Campbell, Anna Quattropani, Agnes Bombrun, Christophe Cleva, Marilène Gaudet, Gwenaelle Bouscary-Desforges, Marc Missotten, Stefano Crosignani, Hamina Daff, Kamel El Harkani, Tania Grippi-Vallotton, Nada Abla, Christèle Frémaux, Catherine Jorand-Lebrun, Zoë Johnson, Yves Humbert, Olivier Schott, Jean-François Arrighi, Charles G. Bradshaw, Mikaël Pâquet, Adeline Pretre, Pittet Pierre-Andre
Publikováno v:
ACS medicinal chemistry letters. 2(12)
Antagonism of the CRTH2 receptor represents a very attractive target for a variety of allergic diseases. Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding. However, potential acid metabolites O-acyl