Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Gwenaëlle Auregan"'
1
Akademický článek
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
Autor: Noémie Cresto, Marie-Claude Gaillard, Camille Gardier, Francesco Gubinelli, Elsa Diguet, Déborah Bellet, Laurine Legroux, Julien Mitja, Gwenaëlle Auregan, Martine Guillermier, Charlène Josephine, Caroline Jan, Noëlle Dufour, Alain Joliot, Philippe Hantraye, Gilles Bonvento, Nicole Déglon, Alexis-Pierre Bemelmans, Karine Cambon, Géraldine Liot, Emmanuel Brouillet
Publikováno v: Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2G2019S are thought to result from an increase in its kinase activity as compared t
Externí odkaz: https://doaj.org/article/f99d8776c12c4a7bb6880f866319890e
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2
Akademický článek
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo
Autor: Noémie Cresto, Camille Gardier, Marie-Claude Gaillard, Francesco Gubinelli, Pauline Roost, Daniela Molina, Charlène Josephine, Noëlle Dufour, Gwenaëlle Auregan, Martine Guillermier, Suéva Bernier, Caroline Jan, Pauline Gipchtein, Philippe Hantraye, Marie-Christine Chartier-Harlin, Gilles Bonvento, Nadja Van Camp, Jean-Marc Taymans, Karine Cambon, Géraldine Liot, Alexis-Pierre Bemelmans, Emmanuel Brouillet
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13, p 6760 (2021)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson’s disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understoo
Externí odkaz: https://doaj.org/article/22c7a6ea143b4f2585dbefbd517cfee2
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3
Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state
Autor: Fanny Petit, Erwan Selingue, Charlène Joséphine, Gilles Bonvento, Gwenaëlle Auregan, Anne-Sophie Hérard, Marie D’orange, Emmanuel Brouillet, Carole Escartin, Martine Guillermier, Mylène Gaudin-Guérif, Alexis-Pierre Bemelmans, Pauline Gipchtein, Emma Augustin, Anastasie Maté de Gérando, Karine Cambon, Marie-Claude Gaillard, Philippe Hantraye, Lev Stimmer, Caroline Jan, David Blum, Kevin Carvalho
Publikováno v: Brain-A Journal of Neurology
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, ⟨10.1093/brain/awab011⟩
Brain-A Journal of Neurology, Oxford University Press (OUP), 2021, 12 (4), pp.1167-1182. ⟨10.3389/fneur.2021.654850⟩
Brain-A Journal of Neurology, 2021, 12 (4), pp.1167-1182. ⟨10.1093/brain/awab011⟩
Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the origin of astrocytic tau is s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a567fe58b57d7ba47f62a4764c0b5c3
https://hal.archives-ouvertes.fr/hal-03203343
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4
The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo
Autor: Sueva Bernier, Alexis-Pierre Bemelmans, Noelle Dufour, Gilles Bonvento, Marie-Claude Gaillard, Géraldine Liot, Pauline Gipchtein, Noémie Cresto, Camille Gardier, Philippe Hantraye, Gwenaëlle Auregan, Nadja Van Camp, Daniela Molina, Caroline Jan, Martine Guillermier, Marie-Christine Chartier-Harlin, Francesco Gubinelli, Jean-Marc Taymans, Pauline Roost, Charlène Joséphine, Karine Cambon, Emmanuel Brouillet
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Volume 22
Issue 13
International Journal of Molecular Sciences, Vol 22, Iss 6760, p 6760 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson’s disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understoo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e4f14cf397c9aa3340a960434da9ca
https://hal.science/hal-03452142
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5
The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
Autor: Martine Guillermier, Marie-Claude Gaillard, Géraldine Liot, Déborah Bellet, Gwenaëlle Auregan, Elsa Diguet, Nicole Déglon, Noelle Dufour, Philippe Hantraye, Francesco Gubinelli, Julien Mitja, Karine Cambon, Noémie Cresto, Emmanuel Brouillet, Charlène Joséphine, Alain Joliot, Camille Gardier, Caroline Jan, Gilles Bonvento, Laurine Legroux, Alexis-Pierre Bemelmans
Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Neurobiology of Disease, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
International audience; The G2019S substitution in the kinase domain of LRRK2 (LRRK2 G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2 G2019S are thought to result from an increase in its kin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24321246af441b617fd04891e482496
https://hal.archives-ouvertes.fr/hal-03043360/document
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7
Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8
Autor: Deniz Dalkara, Alexis-Pierre Bemelmans, Hanen Khabou, José-Alain Sahel, Stéphane Fouquet, Céline Winckler, Gwenaëlle Auregan, Melissa Desrosiers
Publikováno v: Biotechnology and Bioengineering. 113:2712-2724
Recently, we described a modified AAV2 vector—AAV2-7m8—having a capsid-displayed peptide insertion of 10 amino acids with enhanced retinal transduction properties. The insertion of the peptide referred to as 7m8 is responsible for high-level gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d7ae6a4401587ed06284a787f5e5691
https://doi.org/10.1002/bit.26031
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9
Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8
Autor: Hanen, Khabou, Mélissa, Desrosiers, Céline, Winckler, Stéphane, Fouquet, Gwenaëlle, Auregan, Alexis-Pierre, Bemelmans, José-Alain, Sahel, Deniz, Dalkara
Publikováno v: Biotechnology and bioengineering. 113(12)
Recently, we described a modified AAV2 vector-AAV2-7m8-having a capsid-displayed peptide insertion of 10 amino acids with enhanced retinal transduction properties. The insertion of the peptide referred to as 7m8 is responsible for high-level gene del
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb8d6da36e01fca3529dced47f9b1735
https://pubmed.ncbi.nlm.nih.gov/27259396
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10
Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter
Autor: Karine Cambon, Sandrine Betuing, Jocelyne Caboche, Christiane Pagès, Gwenaëlle Auregan, Emmanuel Roze, Elodie Martin, Nicole Déglon
Publikováno v: Human Molecular Genetics
Huntington's disease (HD) is a neurodegenerative disorder due to abnormal polyglutamine expansion in huntingtin protein (Exp-Htt). This expansion causes protein aggregation, leading to neuronal dysfunction and death. We have previously shown that mit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9f077dfcf0c7a0bcb50a4895cda3a8
https://doi.org/10.1093/hmg/ddr148
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