Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gwen Tolhurst"'
Autor:
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodo
Externí odkaz:
https://doaj.org/article/e0d5bffcb836471e9eeb57ed1e965989
Autor:
Deborah A. Goldspink, Van B. Lu, Lawrence J. Billing, Pierre Larraufie, Gwen Tolhurst, Fiona M. Gribble, Frank Reimann
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 90-101 (2018)
Objectives: The aim of this study was to investigate the electrical properties of ileal Glucagon-like peptide 1 (GLP-1) secreting L-cells using murine organoid cultures and the electrophysiological and intracellular signaling pathways recruited follo
Externí odkaz:
https://doaj.org/article/9114eb91b75a45ea9ed8146d86524fcb
Publikováno v:
Journal of Visualized Experiments : JoVE
The gut is the largest endocrine organ of the body, with hormone-secreting enteroendocrine cells located along the length of the gastrointestinal epithelium. Despite their physiological importance, enteroendocrine cells represent only a small fractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05855ff3c9fd2e93b7ea59e9ad1e8e
http://europepmc.org/articles/PMC5409300
http://europepmc.org/articles/PMC5409300
Autor:
Frank Reimann, Gwen Tolhurst, Tamara Zietek, Fiona M. Gribble, Helen E. Parker, Hannelore Daniel, Eleftheria Diakogiannaki, Ramona Pais, Beate Rauscher, James A. Horscroft
Publikováno v:
Diabetologia
Aims/hypothesis Ingested protein is a well-recognised stimulus for glucagon-like peptide-1 (GLP-1) release from intestinal L cells. This study aimed to characterise the molecular mechanisms employed by L cells to detect oligopeptides. Methods GLP-1 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6aaff85e1da3a585e2c863405c0531
http://europepmc.org/articles/PMC3825574
http://europepmc.org/articles/PMC3825574
Autor:
Fiona M. Gribble, Abdella M. Habib, Frank Reimann, Eleftheria Diakogiannaki, Helen E. Parker, Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Johannes Grosse, Jennifer Cameron
Publikováno v:
Diabetes
Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a06844111e2f2768d3fb67e419eeba
https://doi.org/10.2337/db11-1019
https://doi.org/10.2337/db11-1019
Autor:
A. Ramzan, Abdella M. Habib, Gwen Tolhurst, Gareth J. Rogers, Frank Reimann, Helen E. Parker, Fiona M. Gribble
Publikováno v:
The Journal of Physiology. 589:1081-1093
Glucagon like peptide 1 (GLP-1) based therapies are now widely used for the treatment of type 2 diabetes. Developing our understanding of intestinal GLP-1 release may facilitate the development of new therapeutics aimed at targeting the GLP-1 produci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9526bfba9366e107d23ef1c0d887cf5
https://doi.org/10.1113/jphysiol.2010.198069
https://doi.org/10.1113/jphysiol.2010.198069
Publikováno v:
Endocrinology
The effects of chemical (DPP-4) inhibition and genetic reduction of DPP-4 activity on bone quality were studied in wild-type and ovariectomized mice.
L-glutamine stimulates glucagon-like peptide 1 (GLP-1) secretion in human subjects and cell lin
L-glutamine stimulates glucagon-like peptide 1 (GLP-1) secretion in human subjects and cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf5752ddb66625c2ea909accbed2eeb
http://europepmc.org/articles/PMC3140224
http://europepmc.org/articles/PMC3140224
Publikováno v:
The Journal of Physiology. 587:27-32
Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8726f90994ea3ab04ee676b906e66b9
https://doi.org/10.1113/jphysiol.2008.164012
https://doi.org/10.1113/jphysiol.2008.164012
Autor:
Iman S. Gurung, Gwen Tolhurst, Jamie I. Vandenberg, Martyn P. Mahaut-Smith, Juan Martinez-Pinna
Publikováno v:
The Journal of Physiology. 555:61-70
G-protein-coupled receptor signalling has been suggested to be voltage dependent in a number of cell types; however, the limits of sensitivity of this potentially important phenomenon are unknown. Using the non-excitable rat megakaryocyte as a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0eafab0f82f4290a4d1e7eda49469b
https://doi.org/10.1113/jphysiol.2003.056846
https://doi.org/10.1113/jphysiol.2003.056846
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642247156
Ingestion of a meal triggers a range of physiological responses both within and outside the gut, and results in the remote modulation of appetite and glucose homeostasis. Luminal contents are sensed by specialised chemosensitive cells scattered throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f18ec947ea3d9b35f5a1eeebe707481
https://doi.org/10.1007/978-3-642-24716-3_14
https://doi.org/10.1007/978-3-642-24716-3_14
