Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gwen S. Scott"'
Publikováno v:
Cellular and Molecular Neurobiology. 29:707-717
The potent oxidant peroxynitrite (ONOO(-)) is formed after the combination of nitric oxide with superoxide and has been closely associated with the pathology of inflammatory disease. In particular, the generation of ONOO(-) has been linked to central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9046217d2f3f934aaa26bdd6c1078d
https://doi.org/10.1007/s10571-009-9391-5
https://doi.org/10.1007/s10571-009-9391-5
Publikováno v:
European Journal of Pharmacology. 601:88-93
There is increasing evidence that the oxidative radical, peroxynitrite (ONOO−), is involved in the pathogenesis of inflammatory diseases including multiple sclerosis and the animal counterpart, experimental autoimmune encephalomyelitis (EAE). Compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833aa265119601ce4b244df050337143
https://doi.org/10.1016/j.ejphar.2008.10.029
https://doi.org/10.1016/j.ejphar.2008.10.029
Autor:
Gideon Gross, Gwen S. Scott, F. Susan Wong, Stephen Chapman, Sigal Fishman, L. Khai Siew, Li Wen, Alon Margalit
Publikováno v:
Annals of the New York Academy of Sciences. 1150:54-58
CD8 T cells play an important role in autoimmune diabetes development, and therefore removing these cells may protect against disease. To test this, we designed a novel method using engineered cells (InsCD3-zeta) to target insulin-specific CD8 T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e336ba461b91977c3187987b8763ff
https://doi.org/10.1196/annals.1447.040
https://doi.org/10.1196/annals.1447.040
Autor:
Timothy W. Phares, Rhonda B. Kean, Sergei Spitsin, Gwen S. Scott, Christine M. Brimer, Marzena J. Fabis, Tatiana Mikheeva, D. Craig Hooper
Publikováno v:
Journal of Neuroimmunology. 155:32-42
Urate (UA) selectively scavenges peroxynitrite-dependent radicals and suppresses CNS inflammation through effects that are manifested at the blood-brain barrier (BBB). ICAM-1 upregulation in the spinal cord tissues of myelin basic protein (MBP) immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e608766216d5a4cef8cdf26e7f6595
https://doi.org/10.1016/j.jneuroim.2004.05.011
https://doi.org/10.1016/j.jneuroim.2004.05.011
Publikováno v:
Journal of Neurotrauma. 21:1255-1263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0815249ae14953c58c9e854a1c483394
https://doi.org/10.1089/0897715041953858
https://doi.org/10.1089/0897715041953858
Publikováno v:
Journal of Neurotrauma. 21:1255-1263
Peroxynitrite, which has been implicated in secondary neuronal damage resulting from spinal cord injury, is capable of mediating several toxic interactions including inducing DNA strand breaks and activating the nuclear enzyme, poly (ADP-ribose) poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed294069a553f04e04b0af09c5fb692
https://doi.org/10.1089/neu.2004.21.1255
https://doi.org/10.1089/neu.2004.21.1255
Autor:
W F Bremner, E L Kanabrocki, J Van Cauteren, Farhed A. Shah, M. C. Johnson, D Murray, P. Shirazi, J. L.H.C. Third, Ramon C. Hermida, B A Nemchausky, S. Foley, D C Hooper, Gwen S. Scott, Diana E. Ayala, M D Ryan
Publikováno v:
Chronobiology International. 21:739-758
The free radical nitric oxide (NO*) is involved in a variety of diverse biological processes from acting as a vasodilator in the cardiovascular system to being the rate-limiting component in the production of peroxynitrite (ONOO-), a contributor to n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f685623505708ef5ec26d449c1734c
https://doi.org/10.1081/cbi-200025981
https://doi.org/10.1081/cbi-200025981
Autor:
Anna Zborek, Mikhail Prosniak, Hilary Koprowski, Timothy W. Phares, Gwen S. Scott, Anirban Roy, D. Craig Hooper
Publikováno v:
Proceedings of the National Academy of Sciences. 100:6765-6770
The contribution of host factors to rabies virus (RV) transcription/replication and axonal/transsynaptic spread is largely unknown. We previously identified several host genes that are up-regulated in the mouse brain during RV infection, including ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f5548f289a9e4ed452232012c046ee
https://doi.org/10.1073/pnas.0430999100
https://doi.org/10.1073/pnas.0430999100
Publikováno v:
Glia. 41:105-116
Oligodendrocyte loss is a characteristic feature of several CNS disor- ders, including multiple sclerosis (MS) and spinal cord injury. However, the mechanisms responsible for oligodendrocyte destruction remain undefined. As recent studies have implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e277d7a61947071b7127db33ee8e711c
https://doi.org/10.1002/glia.10137
https://doi.org/10.1002/glia.10137
Autor:
Parvez Shirazi, Eugene L. Kanabrocki, M D Ryan, Jane L.H.C. Third, D. Craig Hooper, Gwen S. Scott, Bernard A. Nemchausky, Diana E. Ayala, Ramon C. Hermida, Dennis Murray, W. Fraser Bremner
Publikováno v:
Chronobiology International. 19:423-439
Seven clinically healthy, nondiabetic (ND) and four Type II diabetic (D) men were assessed for circadian rhythms in oxidative "stress markers." Blood samples were collected at 3h intervals for approximately 27 h beginning at 19:00h. Urine samples wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3172d433fdb7fdfe28ee7a8bcbf9ad70
https://doi.org/10.1081/cbi-120002914
https://doi.org/10.1081/cbi-120002914