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Germline minisatellite mutations in workers occupationally exposed to radiation at the Sellafield nuclear facility

Autor: Gwen S. Rees, Patricia Jonas, E. Janet Tawn, Gillian B. Curwen

Publikováno v: Journal of Radiological Protection. 35:21-36

Germline minisatellite mutation rates were investigated in male workers occupationally exposed to radiation at the Sellafield nuclear facility. DNA samples from 160 families with 255 offspring were analysed for mutations at eight hypervariable minisa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73788a37c22f8747d8764f9c201bea3d
https://doi.org/10.1088/0952-4746/35/1/21

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Germline minisatellite mutations in survivors of childhood and young adult cancer treated with radiation

Autor: Catherine Rechnitzer, Marilyn Stovall, John D. Boice, E. Janet Tawn, Gwen S. Rees, Gillian B. Curwen, Cheryl Leith, Jørgen H. Olsen, Per Guldberg, Henrik Schroeder, Jeanette Falck Winther

Publikováno v: Tawn, E J, Rees, G S, Leith, C, Winther, J F, Curwen, G B, Stovall, M, Olsen, J H, Rechnitzer, C M A, Schroeder, H & Boice, J D 2010, ' Germline minisatellite mutations in survivors of childhood and young adult cancer treated with radiation ', International Journal of Radiation Biology . https://doi.org/10.3109/09553002.2011.530338

To investigate minisatellite germline mutation rates in survivors of childhood and young adult cancer who received radiotherapy.DNA samples from 100 families, where one parent was a cancer survivor, were analysed for mutations at eight hypervariable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185530c511181b4011b8a6a704a59157
https://doi.org/10.3109/09553002.2011.530338

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Comparison of germ line minisatellite mutation detection at the CEB1 locus by Southern blotting and PCR amplification

Autor: Jeanette Falck Winther, Cheryl Leith, Malcolm Taylor, Anthony Oojageer, Marcin Cieslak, E. Janet Tawn, Gwen S. Rees, Claire Bristow, John D. Boice

Publikováno v: Mutagenesis. 25:343-349

Identification of de novo minisatellite mutations in the offspring of parents exposed to mutagenic agents offers a potentially sensitive measure of germ line genetic events induced by ionizing radiation and genotoxic chemicals. Germ line minisatellit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b806c6df6c1573e30d48368660764952
https://doi.org/10.1093/mutage/geq011

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Genotype Profiles of Loci Encoding DNA Repair Enzymes in Newborn and Elderly Populations: No Evidence of Association with Longevity

Autor: Caroline L Relton, E J Tawn, Craig S. Wilding, Gwen S. Rees

Publikováno v: Biogerontology. 7:35-41

The comparison of genotype frequencies between neonates and elderly populations can aid in the identification of loci, and polymorphisms within those loci, that affect longevity. Here we have compared genotype frequencies of seven polymorphisms at fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fa6253b097566f913ffbe2bdfd5932
https://doi.org/10.1007/s10522-005-6042-1

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Chromosome analysis in childhood cancer survivors and their offspring—No evidence for radiotherapy-induced persistent genomic instability

Autor: Caroline A. Whitehouse, Marilyn Stovall, Catherine Rechnitzer, Per Guldberg, Jeanette Falck Winther, Gillian B. Curwen, Henrik Daa Schrøder, John D. Boice, Gwen S. Rees, Jørgen H. Olsen, E. Janet Tawn

Publikováno v: Tawn, EJ, Whitehouse, CA, Winther, JF, Curven, GB, Rees, GS, Stovall, M, Olsen, JH, Guldberg, P, Rechnitzer, C, Schrøder, H & Boyce, JD 2005, ' Chromosome analysis in childhood cancer survivors and their offspring-No evidence for radiotherapy-induced persistent genomic instability. ', Mutation Research-Reviews in Mutation Research, vol. 583, pp. 198-206 .

Suggestions that the induction of genomic instability could play a role in radiation-induced carcinogenesis and heritable disease prompted the investigation of chromosome instability in relation to radiotherapy for childhood cancer. Chromosome analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b8df6c007c86e095a343ca79b82ee4
https://doi.org/10.1016/j.mrgentox.2005.03.007

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DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers

Autor: Caroline L Relton, Craig S. Wilding, Caroline A. Whitehouse, Gwen S. Rees, E. Janet Tawn, Robert E. Tarone

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 570:137-145

Polymorphic variation in DNA repair genes was examined in a group of retired workers from the British Nuclear Fuels plc facility at Sellafield in relation to previously determined translocation frequencies in peripheral blood lymphocytes. Variation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21e1b0ec7af680d3c1f2ee34d405e2d
https://doi.org/10.1016/j.mrfmmm.2004.11.002

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Occupational exposure to ionizing radiation has no effect on T‐ and B‐cell total counts or percentages of helper, cytotoxic and activated T‐cell subsets in the peripheral circulation of male radiation workers

Autor: S. D. Morris, E. J. Tawn, Gwen S. Rees, Caroline A. Whitehouse, D. H. MacGregor, K. Binks, C. P. Daniel

Publikováno v: International Journal of Radiation Biology. 80:493-498

To investigate changes in immune cell subsets in the peripheral circulation of a male population occupationally exposed to ionizing radiation.Peripheral blood samples were taken from 194 male workers with cumulative exposures of200 mSv (mean exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9f3a16f980c43c76d100154bad2a72
https://doi.org/10.1080/09553000410001725099

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Lack of correlation of free deoxypyridinoline excretion with Taq1 restriction length polymorphisms in the vitamin D receptor gene in males

Autor: Stephen Legon, Richard S. Chapman, Gwen S Rees, Claire G Nicholl, Elizabeth K Symes

Publikováno v: Clinica Chimica Acta. 272:149-157

An association between allelic variants in the vitamin D receptor gene and bone mineral density has been previously described. A bimodal variation in the rate of bone resorption (as measured by urinary deoxypyridinoline excretion rate) has also been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852a4f868b9ae96fca869d3dd52e3a31
https://doi.org/10.1016/s0009-8981(98)00016-3

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The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring

Autor: Jeanette Falck Winther, Gwen S. Rees, E. Janet Tawn, Per Guldberg, Catherine Rechnitzer, Henrik Schroeder, John D. Boice, Heather J. Cordell, Kevin K. Cadwell, Jørgen H. Olsen, Gillian B. Curwen

Publikováno v: Curwen, G B, Cadwell, K K, Winther, J F, Tawn, E J, Rees, G S, Olsen, J H, Rechnitzer, C M A, Schroeder, H, Guldberg, P, Cordell, H J & Boice, J D 2010, ' The heritability of G2 chromosomal radiosensitivity and its association with cancer in Danish cancer survivors and their offspring ', International Journal of Radiation Biology, vol. 86, no. 11, pp. 986-95 . https://doi.org/10.3109/09553002.2010.496027

To investigate the relationship between chromosomal radiosensitivity and early-onset cancer under the age of 35 years and to examine the heritability of chromosomal radiosensitivity.Peripheral blood lymphocytes were cultured for 72 hours prior to bei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466123459d2fb7b53c51a3bef9239a2f
https://europepmc.org/articles/PMC3777830/

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A pilot study examining germline minisatellite mutations in the offspring of Danish childhood and adolescent cancer survivors treated with radiotherapy

Autor: Per Guldberg, Henrik Daa Schrøder, Jeanette Falck Winther, Catherine Rechnitzer, Michael Z. Trikic, Gwen S. Rees, John D. Boice, Marilyn Stovall, E. Janet Tawn, Jørgen H. Olsen

Publikováno v: Rees, GS, Trikic, MZ, Winther, JF, Tawn, EJ, Stovall, M, Olsen, JH, Rechnitzer, C, Schrøder, H, Guldberg, P & Boice Jr, JD 2006, ' A pilot study examining germline minisatellite mutations in the offspring of Danish childhood and adolescent cancer survivors treated with radiotherapy ', Int. J. Radiat. Biol., vol. 82, pp. 153-160 .

To investigate germline mutation rate at eight minisatellite loci in 24 Danish families, where one parent is the survivor of childhood or adolescent cancer treated with radiotherapy.Parents and offspring were profiled for eight hypervariable minisate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db891778f9b2e141cb988f6a538f63b
https://pure.au.dk/portal/da/publications/a-pilot-study-examining-germline-minisatellite-mutations-in-the-offspring-of-danish-childhood-and-adolescent-cancer-survivors-treated-with-radiotherapy(4ff510d0-c893-11db-bee9-02004c4f4f50).html

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