Výsledky vyhledávání - "Gwen McCaffrey"

Supplementary Video 2 from NGF Blockade at Early Times during Bone Cancer Development Attenuates Bone Destruction and Increases Limb Use

Autor: Patrick W. Mantyh, Geraldine Longo, Stephane Chartier, Michelle N. Fealk, Lisa Majuta, Michelle L. Thompson, Gwen McCaffrey

This film depicts the spontaneous nocifensive behavior of a mouse at Day 17 post-cancer cell injection. Throughout the film there are several visual cues that are indicative of nocifensive behavior. The pronounced changes in behavior and movements of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd9dc3033d5eb7310609014f602e5e8
https://doi.org/10.1158/0008-5472.22403099.v1

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Supplementary Video 1 from NGF Blockade at Early Times during Bone Cancer Development Attenuates Bone Destruction and Increases Limb Use

Autor: Patrick W. Mantyh, Geraldine Longo, Stephane Chartier, Michelle N. Fealk, Lisa Majuta, Michelle L. Thompson, Gwen McCaffrey

This film depicts the nocifensive behavior of a naÃƒÂ¯ve mouse. During the film, when the mouse is stationary, the toes of the left foot are spread out and a range of brightness appears on the bottom of the foot because it is bearing weight on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c95f5facc642f34099e63bd6a8dd7d9
https://doi.org/10.1158/0008-5472.22403105.v1

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Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor

Autor: Geraldine Longo, Michelle N. Fealk, Lisa A. Majuta, Gwen McCaffrey, Patrick W. Mantyh

Publikováno v: Pain. 156:157-165

The number of patients suffering from postoperative pain due to orthopedic surgery and bone fracture is projected to dramatically increase because the human life span, weight, and involvement in high-activity sports continue to rise worldwide. Joint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce17f39347cae7fa7960bc79f2ebb5ea
https://doi.org/10.1016/j.pain.0000000000000017

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NGF Blockade at Early Times during Bone Cancer Development Attenuates Bone Destruction and Increases Limb Use

Autor: Geraldine Longo, Lisa A. Majuta, Michelle N. Fealk, Stephane R. Chartier, Patrick W. Mantyh, Michelle L. Thompson, Gwen McCaffrey

Publikováno v: Cancer Research. 74:7014-7023

Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain is important, a largely unanswered question is what other benefits NGF blockade might conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8de3251e8fd0323f3a12dc801f07ccf
https://doi.org/10.1158/0008-5472.can-14-1220

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Physiology and Pathophysiology of the Blood-Brain Barrier: P-Glycoprotein and Occludin Trafficking as Therapeutic Targets to Optimize Central Nervous System Drug Delivery

Autor: Gwen McCaffrey, Thomas P. Davis

Publikováno v: Journal of Investigative Medicine. 60:1131-1140

The blood-brain barrier (BBB) is a physical and metabolic barrier that separates the central nervous system from the peripheral circulation. Central nervous system drug delivery across the BBB is challenging, primarily because of the physical restric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9709c8910c12ea729c8123ee59087bd
https://doi.org/10.2310/jim.0b013e318276de79

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P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia

Autor: Patrick T. Ronaldson, Mei Li Laracuente, Thomas P. Davis, Kristen Demarco, William D. Staatz, Gwen McCaffrey, Jessica D. Finch, Lucy Sanchez-Covarrubias

Publikováno v: Journal of Neurochemistry. 122:962-975

P-glycoprotein (ABCB1/MDR1, EC 3.6.3.44), the major efflux transporter at the blood-brain barrier (BBB), is a formidable obstacle to CNS pharmacotherapy. Understanding the mechanism(s) for increased P-glycoprotein activity at the BBB during periphera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c40939c2e0b53811fa1712947d6240f
https://doi.org/10.1111/j.1471-4159.2012.07831.x

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Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Autor: Jeffrey J. Lochhead, Kristin M. DeMarco, Lucy Sanchez-Covarrubias, Jessica D. Finch, Colleen E. Quigley, Gwen McCaffrey, Thomas P. Davis, Patrick T. Ronaldson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 302:H582-H593

Our laboratory has shown that λ-carrageenan-induced peripheral inflammatory pain (CIP) can alter tight junction (TJ) protein expression and/or assembly leading to changes in blood-brain barrier xenobiotic permeability. However, the role of reactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd781906543b09aaee7fba4d14b06b63
https://doi.org/10.1152/ajpheart.00889.2011

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Occludin oligomeric assemblies at tight junctions of the blood-brain barrier are altered by hypoxia and reoxygenation stress

Autor: Colin L. Willis, Jeffrey J. Lochhead, Carolyn A. Quigley, William D. Staatz, Gwen McCaffrey, Thomas P. Davis, Nicole Nametz, Sharon Hom

Publikováno v: Journal of Neurochemistry. 110:58-71

Hypoxic (low oxygen) and reperfusion (post-hypoxic reoxygenation) phases of stroke promote an increase in microvascular permeability at tight junctions (TJs) of the blood-brain barrier (BBB) that may lead to cerebral edema. To investigate the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381136868886742995ca2989354c4ff7
https://doi.org/10.1111/j.1471-4159.2009.06113.x

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