Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gwen M. Taylor"'
Autor:
Boyang Zhao, Liya Hu, Soni Kaundal, Neetu Neetu, Christopher H. Lee, Xayathed Somoulay, Banumathi Sankaran, Gwen M. Taylor, Terence S. Dermody, B. V. Venkataram Prasad
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid assembly. Despite its functional importance, a mechanistic understanding of σNS is la
Externí odkaz:
https://doaj.org/article/6d37c72a4b954eeeb9d6bf567f95912f
Autor:
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To id
Externí odkaz:
https://doaj.org/article/3daf5306cc154b38afd87eb89709065d
Autor:
Pamela H. Brigleb, Elaine Kouame, Kay L. Fiske, Gwen M. Taylor, Kelly Urbanek, Luzmariel Medina Sanchez, Reinhard Hinterleitner, Bana Jabri, Terence S. Dermody
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Celiac disease is an immune-mediated intestinal disorder that results from loss of oral tolerance (LOT) to dietary gluten. Reovirus elicits inflammatory Th1 cells and suppresses Treg responses to dietary antigen in a strain-dependent manner. Strain t
Externí odkaz:
https://doaj.org/article/41f555ddcfee4228a842aa0511f1c5a2
Autor:
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovi
Externí odkaz:
https://doaj.org/article/fbf6adbb4e59406fb675881fcf04dd69
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Physical distancing imposed by the COVID-19 pandemic has led to alterations in routines and new responsibilities for much of the research community. We provide some tips for how research teams can cope with physical distancing, some of which
Externí odkaz:
https://doaj.org/article/f5e950f0592647b0a589d5ce981ee18b
Autor:
Gwen M. Taylor, Andrea J. Pruijssers, Pamela H. Brigleb, Kay L. Fiske, Pengcheng Shang, Kelly Urbanek, Judy J. Brown, Dhivyaa Rajasundaram, Terence S. Dermody
Publikováno v:
J Virol
Pathological effects of apoptosis associated with viral infections of the central nervous system are an important cause of morbidity and mortality. Reovirus is a neurotropic virus that causes apoptosis in neurons, leading to lethal encephalitis in ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a13607c27db032c6af02b837a5607db
https://doi.org/10.1128/jvi.01442-22
https://doi.org/10.1128/jvi.01442-22
Autor:
Magdalena Siller, Yanlin Zeng, Luzmariel Medina Sanchez, Pamela H. Brigleb, Kishan A. Sangani, Mohit Rana, Lauren Van Der Kraak, Surya P. Pandey, Mackenzie J. Bender, Britney Fitzgerald, Lee Hedden, Kay Fiske, Gwen M. Taylor, Syed A Rahman, Heather J. Galipeau, Steven J. Mullet, Stacy G. Wendell, Simon C. Watkins, Premysl Bercik, Jishnu Das, Marlies Meisel, Bana Jabri, Terence S. Dermody, Elena F. Verdú, Reinhard Hinterleitner
Loss of oral tolerance (LOT) to gluten, characterized by a T helper 1 (Th1) gluten-specific immune response, is a hallmark of celiac disease (CeD) and can be triggered by enteric viral infections. We hypothesized that certain gut microbes have the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7d98e5938940d9857a1ccd693fe50f
https://doi.org/10.1101/2022.06.21.497012
https://doi.org/10.1101/2022.06.21.497012
Autor:
John S. L. Parker, Cristina Risco, Raquel Tenorio, Gwen M. Taylor, Krishnan Raghunathan, Christopher H Lee, Isabel Fernández de Castro, Andrea J. French, Terence S. Dermody
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
mBio
mBio
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914c5bbeb910c5797192ead5fc2cb311
https://doi.org/10.1128/mbio.01408-21
https://doi.org/10.1128/mbio.01408-21
Autor:
R. Moreno, D. M. Sutherland, Melanie Koehler, Camila Guzman-Cardozo, Zhengjia Wang, B.V.V. Prasad, Jonathan J. Knowlton, Olivia L. Welsh, P. Woerz, Liya Hu, M. Strebl, Gwen M. Taylor, R. dos Santos Natividade, Pavithra Aravamudhan, Terence S. Dermody, Xinzhe Yu, David Alsteens, Z. L. Lonergan, Thilo Stehle
Human Nogo-66 receptor 1 (NgR1) is a receptor for mammalian orthoreoviruses (reoviruses), but the mechanism of virus-receptor engagement is unknown. NgR1 binds a variety of structurally dissimilar ligands in the adult central nervous system (CNS) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5318e64e208b5b90720ec34afdc63e
https://doi.org/10.1101/2021.07.23.453469
https://doi.org/10.1101/2021.07.23.453469
Autor:
Daniel R. Gestaut, Nathan A. Yates, Alexander Leitner, Gregory J. Wilson, Sreejesh Shanker, Judith Frydman, Wah Chiu, B. V. Venkataram Prasad, Ruedi Aebersold, Boxue Ma, Jonathan J. Knowlton, Terence S. Dermody, Gwen M. Taylor, Alpay B. Seven
Publikováno v:
Proc Natl Acad Sci U S A
Intracellular protein homeostasis is maintained by a network of chaperones that function to fold proteins into their native conformation. The eukaryotic TRiC chaperonin (TCP1-ring complex, also called CCT for cytosolic chaperonin containing TCP1) fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9add39fee5ed7a8c422ec7a68b95b9a
https://europepmc.org/articles/PMC7980406/
https://europepmc.org/articles/PMC7980406/