Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gwen Jordaan"'
Autor:
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S. Chang, Jacquelyn T. Saunders, Mohammad T. Bashir, James E. Hansen, Joseph Gera, Richard H. Weisbart, Robert N. Nishimura
Publikováno v:
Cell Stress and Chaperones.
Heat shock proteins (HSPs), especially Hsp70 (HSPA1), have been associated with cellular protection from various cellular stresses including heat, hypoxia-ischemia, neurodegeneration, toxins, and trauma. Endogenous HSPs are often synthesized in direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5088e42a4fd95c0d30dfd168cdfab94
https://doi.org/10.1007/s12192-023-01349-6
https://doi.org/10.1007/s12192-023-01349-6
Autor:
Chris Hino, Grace Chan, Gwen Jordaan, Sophia S Chang, Jacquelyn T Saunders, Mohammad T Bashir, James E Hansen, Joseph Gera, Richard H Weisbart, Robert N Nishimura
Heat shock proteins (HSPs), especially Hsp70 (HSPA1), have been associated with cellular protection from various cellular stresses including heat, hypoxia-ischemia, neurodegeneration, toxins, and trauma. Endogenous HSPs are often synthesized in direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a5f5c4abf1e10850f4f5e179a746a8
https://doi.org/10.1101/2023.02.22.529417
https://doi.org/10.1101/2023.02.22.529417
Publikováno v:
International Journal of Cancer. 138:182-186
TP53 is a tumor suppressor gene that is mutated in 50% of cancers, and its function is tightly regulated by the E3 ligase, Mdm2. Both p53 and Mdm2 are localized in the cell nucleus, a site that is impervious to therapeutic regulation by most antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51589ac52f51c263ea76c2aed0bc5d1c
https://doi.org/10.1002/ijc.29685
https://doi.org/10.1002/ijc.29685
Publikováno v:
BMC Cancer
BMC cancer, vol 15, iss 1
BMC cancer, vol 15, iss 1
Background To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq) analysis was performed. Methods Ten CLL specimens and five normal peripheral blood C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1458259c077554c2ae2ae567ee1219f8
http://europepmc.org/articles/PMC4609092
http://europepmc.org/articles/PMC4609092
Autor:
Yanfeng Liu, Peter M. Glazer, Gwen Jordaan, Grace Chan, Robert N. Nishimura, Richard H. Weisbart, Philip W. Noble, James E. Hansen
Publikováno v:
Scientific Reports
A nuclear-penetrating lupus anti-DNA autoantibody, 3E10, has been found to inhibit DNA repair and selectively kill certain cancer cells that are highly vulnerable to DNA damage. In addition, a 3E10 single chain variable fragment (scFv) has been devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a86b646b6415dfdc266c1835c560e8
Publikováno v:
International journal of cancer. 138(1)
TP53 is a tumor suppressor gene that is mutated in 50% of cancers, and its function is tightly regulated by the E3 ligase, Mdm2. Both p53 and Mdm2 are localized in the cell nucleus, a site that is impervious to therapeutic regulation by most antibodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07db4ff335150724a424a15964c116ac
https://pubmed.ncbi.nlm.nih.gov/26174762
https://pubmed.ncbi.nlm.nih.gov/26174762
Publikováno v:
Leukemialymphoma. 55(12)
Rasgrf-1 is a guanine exchange factor (GEF) that catalyzes the exchange of GDP for GTP. In a RNA microarray analysis of chronic lymphocytic leukemia (CLL) specimens (n = 5), this gene was found to be overexpressed in CLL as compared to normal periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882a8162d223475d9cbb18a14c1ba2bc
https://pubmed.ncbi.nlm.nih.gov/24597981
https://pubmed.ncbi.nlm.nih.gov/24597981
Publikováno v:
Jordaan, Gwen; Liao, Wei; & Sharma, Sanjai. (2013). E-cadherin gene re-expression in chronic lymphocytic leukemia cells by HDAC inhibitors. BMC Cancer, 13(1), 88. doi: http://dx.doi.org/10.1186/1471-2407-13-88. Retrieved from: http://www.escholarship.org/uc/item/6ct6x37s
BMC Cancer
BMC Cancer, Vol 13, Iss 1, p 88 (2013)
BMC Cancer
BMC Cancer, Vol 13, Iss 1, p 88 (2013)
Background The tumor suppressor gene E-cadherin gene is frequently silenced in chronic lymphocytic leukemia (CLL) cells and results in wnt-pathway activation. We analyzed the role of histone epigenetic modifications in E-cadherin gene silencing. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20b049e58aa85afd7999f81b7380dea
https://doi.org/10.1186/1471-2407-13-88
https://doi.org/10.1186/1471-2407-13-88
Rasgrf1 Overexpression Amplifies B Cell Receptor Signaling in Chronic Lymphocytic Leukemia Specimens
Publikováno v:
Blood. 120:926-926
Abstract 926 The B-cell receptor (BCR) signaling is a hallmark of chronic lymphocytic leukemia cells and results in cell proliferation, survival and resistance to apoptosis. B cell receptor (BCR) signaling in CLL specimens activates the Ras/ERK/MAPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9fbf2085c5dbf60499cde5c00d38478
https://doi.org/10.1182/blood.v120.21.926.926
https://doi.org/10.1182/blood.v120.21.926.926
Publikováno v:
Blood. 120:4582-4582
Abstract 4582 High throughput sequencing of cellular mRNA provides a comprehensive analysis of the transcriptome. Besides identifying differentially expressed genes in different cell types, it also provides information of mRNA isoforms and splicing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7414f6134ceea1c608b93d1d4b3dc6
https://doi.org/10.1182/blood.v120.21.4582.4582
https://doi.org/10.1182/blood.v120.21.4582.4582