NX210c drug candidate peptide strengthens mouse and human blood-brain barriers

Autor: Chris Greene, Nicolas Rebergue, Gwen Fewell, Damir Janigro, Yann Godfrin, Matthew Campbell, Sighild Lemarchant

Publikováno v: Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-18 (2024)

Abstract Background Alterations of blood-brain barrier (BBB) and blood-spinal cord barrier have been documented in various animal models of neurodegenerative diseases and in patients. Correlations of these alterations with functional deficits suggest

Externí odkaz: https://doaj.org/article/b5f4de81a7ab4505a41b578aceecbd81

Application of blood brain barrier models in pre-clinical assessment of glioblastoma- targeting CAR-T based immunotherapies

Autor: Anna Jezierski, Jez Huang, Betty (Ying) Li, Claudie Charlebois, Tina Nguyen, Ziying Liu, Darin Bloemberg, Ahmed Zafer, Ewa Baumann, Caroline Sodja, Sonia Leclerc, Gwen Fewell, Qing Liu, Balabhaskar Prabhakarpandian, Scott McComb, Danica B. Stanimirovic

Human blood brain barrier (BBB) models derived from induced pluripotent stem cell (iPSC) have become an important tool for discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Chimeric antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d930f7fe2945d57d9f3ebb16765cd200
https://doi.org/10.21203/rs.3.rs-1466429/v1

Vomeronasal organ: electrical stimulation activates Fos in mating pathways and in GnRH neurons

Autor: Gwen Fewell, Michael Meredith

Publikováno v: Brain Research. 922:87-94

Electrical stimulation of the vomeronasal organ in male hamsters activated Fos expression in neurons of the chemosensory pathways, as in experiments where animals were stimulated with female chemical stimuli. Fos was also activated in gonadotropin ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9118b799eb04c29c35dcae3487f7d6fe
https://doi.org/10.1016/s0006-8993(01)03153-5

Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies.

Autor: Huang, Jez¹ (AUTHOR), Li, Ying Betty¹ (AUTHOR), Charlebois, Claudie¹ (AUTHOR), Nguyen, Tina¹ (AUTHOR), Liu, Ziying¹ (AUTHOR), Bloemberg, Darin¹ (AUTHOR), Zafer, Ahmed¹ (AUTHOR), Baumann, Ewa¹ (AUTHOR), Sodja, Caroline¹ (AUTHOR), Leclerc, Sonia¹ (AUTHOR), Fewell, Gwen² (AUTHOR), Liu, Qing¹ (AUTHOR), Prabhakarpandian, Balabhaskar³ (AUTHOR), McComb, Scott^1,4 (AUTHOR), Stanimirovic, Danica B.¹ (AUTHOR), Jezierski, Anna^1,4 (AUTHOR) anna.jezierski@nrc-cnrc.gc.ca

Publikováno v: Fluids & Barriers of the CNS. 6/1/2022, Vol. 19 Issue 1, p1-15. 15p.