Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gwen E. Owens"'
Autor:
Baehyun Shin, Roy Jung, Hyejin Oh, Gwen E. Owens, Hyeongseok Lee, Seung Kwak, Ramee Lee, Susan L. Cotman, Jong-Min Lee, Marcy E. MacDonald, Ji-Joon Song, Ravi Vijayvargia, Ihn Sik Seong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 416-428 (2018)
The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters
Externí odkaz:
https://doaj.org/article/fc7145233c5c473aaf6cd4dcf749ad7c
Autor:
Christopher W. Connor, Gwen E. Owens
Publikováno v:
Anesth Analg
BACKGROUND: Modern consumer electronic devices and automobiles are often controlled by interfaces that sense physical gestures and spoken commands. In contrast, patient monitors and anesthesia devices are typically equipped with panel-mounted buttons
Autor:
Hyeongseok Lee, Ramee Lee, Gwen E. Owens, Roy Jung, Seung Kwak, Ihn Sik Seong, Baehyun Shin, Ji-Joon Song, Jong-Min Lee, Hye Jin Oh, Susan L. Cotman, Ravi Vijayvargia, Marcy E. MacDonald
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 416-428 (2018)
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 416-428 (2018)
The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s Disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters
Autor:
David A. Cooper, Julia Ashlyn Manzella, Daniel S. Connor, Brittney L. Macon, Alejandra I. Olvera, Pamela J. Bjorkman, Robyn Rouleau, Danielle M. New, Gwen E. Owens, Joshua C. Dunn
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
Microgravity was used in an attempt to define the crystal structure of the polyQ repeat of huntingtin alone or bound to MW1, an anti-polyQ Fab. While huntingtin was not crystallized in the experiments, analysis of microgravity-grown and Earth-grown M
Autor:
David M, Hoganson, Eric B, Finkelstein, Gwen E, Owens, James C, Hsiao, Kurt Y, Eng, Katherine M, Kulig, Ernest S, Kim, Tatiana, Kniazeva, Irina, Pomerantseva, Craig M, Neville, James R, Turk, Bernard, Fermini, Jeffrey T, Borenstein, Joseph P, Vacanti
Publikováno v:
Biomicrofluidics. 10(5)
In pre-clinical safety studies, drug-induced vascular injury (DIVI) is defined as an adverse response to a drug characterized by degenerative and hyperplastic changes of endothelial cells and vascular smooth muscle cells. Inflammation may also be see
Autor:
Joseph P. Vacanti, Elisabeth M. O’Doherty, Russell T. Kronengold, Scott M. Goldman, David M. Hoganson, Dina O. Harilal, Gwen E. Owens, Craig M. Neville, Chris M. Bowley
Publikováno v:
Biomaterials. 31:6730-6737
Decellularized dermis materials demonstrate considerable utility in surgical procedures including hernia repair and breast reconstruction. A new decellularized porcine dermis material has been developed that retains many native extracellular matrix (
Autor:
Chris M. Bowley, Craig M. Neville, Elisabeth M. O’Doherty, David M. Hoganson, Dina O. Harilal, Russell T. Kronengold, Scott M. Goldman, Gwen E. Owens, Joseph P. Vacanti
Publikováno v:
Biomaterials. 31:6934-6940
Mesothelium tissues such as peritoneum and pleura have a thin and strong layer of extracellular matrix that supports mesothelial cells capable of rapid healing. Decellularized porcine mesothelium was characterized for strength, composition of the mat
Autor:
Joseph P. Vacanti, Peter T. Masiakos, Alison Hart, Elisabeth M. O’Doherty, Gwen E. Owens, David M. Hoganson, Cathryn A. Sundback, Howard I. Pryor
Publikováno v:
Surgery. 146:490-497
Background The objectives of this study were to evaluate the efficacy of poly(glycerol) sebacate (PGS) films for the prevention of visceroparietal peritoneal (VP) adhesions and demonstrate the ease of laparoscopic PGS film placement. Peritoneal adhes
Autor:
David M, Hoganson, Gwen E, Owens, Amanda M, Meppelink, Erik K, Bassett, Chris M, Bowley, Cameron J, Hinkel, Eric B, Finkelstein, Scott M, Goldman, Joseph P, Vacanti
Publikováno v:
Journal of biomedical materials research. Part A. 104(7)
Extracellular matrix (ECM) materials from animal and human sources have become important materials for soft tissue repair. Microparticles of ECM materials have increased surface area and exposed binding sites compared to sheet materials. Decellulariz
Publikováno v:
Owens, GE; New, DM; Jr, WAP; & Bjorkman, PJ. (2015). Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1. JOURNAL OF MOLECULAR BIOLOGY, 427(15), 2507-2519. doi: 10.1016/j.jmb.2015.05.023. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/4xb9b5n5
Huntington’s disease (HD) is caused by expansion of a polyglutamine (polyQ) repeat in the huntingtin protein. A structural basis for the apparent transition between normal and disease-causing expanded polyQ repeats of huntingtin is unknown. The ‘