Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gwen A Lomberk"'
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
Autor:
Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-10 (2023)
Abstract In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of these cell fate decisions remain largely unknown, particularly in normal cells. H
Externí odkaz:
https://doaj.org/article/ec7f0cfa3b1b4e0b99fa62ec85368f3d
Autor:
David L. Marks, Rachel L. Olson, Raul Urrutia, Daniel D. Billadeau, Nilotpal Roy, George A. Calin, Muller Fabbri, Marina Koutsioumpa, Dimitrios Iliopoulos, Tamas Ordog, Robert Huebert, Olga Sarmento, Adebowale O. Bamidele, William Faubion, Gwen L. Lomberk, Jens Siveke, Nita Ahuja, Juan Iovanna, Ryan A. Hlady, Keith Robertson, John Kisiel, Christopher L. Pin, Martin E. Fernandez-Zapico
Publikováno v:
Epigenetics, Vol 13, Iss 4, Pp 449-457 (2018)
International experts gathered at the Mayo Clinic (Rochester MN, USA) on February 27th-28th, 2017 for a meeting entitled ‘Basic and Translational Facets of the Epigenetics of GI Diseases’. This workshop summarized recent advances on the role of e
Externí odkaz:
https://doaj.org/article/23e86de7b3ef46bbaca872d31226b0f5
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
PDF file - 7K, The summary of the TMZ response: Parental vs TMZ resistant xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172784930a71d2c585d86499332ca6ed
https://doi.org/10.1158/1078-0432.22445216
https://doi.org/10.1158/1078-0432.22445216
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
PDF file - 133K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1590944a85f308b16dbfd20c144560ec
https://doi.org/10.1158/1078-0432.22445219
https://doi.org/10.1158/1078-0432.22445219
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
PDF file - 100K, Kaplan-Meier survival plots: Parental vs TMZ resistant xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234b2d4e303d9c544b92a7062caeb5fd
https://doi.org/10.1158/1078-0432.22445228.v1
https://doi.org/10.1158/1078-0432.22445228.v1
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
Purpose: The therapeutic benefit of temozolomide in glioblastoma multiforme (GBM) is limited by resistance. The goal of this study was to elucidate mechanisms of temozolomide resistance in GBM.Experimental Design: We developed an in vivo GBM model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86673b1fc9fedd7ba5a70e68cd2cdfe5
https://doi.org/10.1158/1078-0432.c.6520421
https://doi.org/10.1158/1078-0432.c.6520421
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
PDF file - 99K, MSH6 mutation in TMZ resistant GBM22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa33c3026c7a898bed89f56d8481557
https://doi.org/10.1158/1078-0432.22445225
https://doi.org/10.1158/1078-0432.22445225
Autor:
Jann N. Sarkaria, Raul A. Urrutia, Shiv K. Gupta, Gwen A. Lomberk, Wenting Wu, Paul A. Decker, Ling Cen, Jenny L. Pokorny, Mark A. Schroeder, Brett L. Carlson, Ann C. Mladek, Gaspar J. Kitange
PDF file - 47K, MGMT promoter methylation by pyrosequencing: Parental vs TMZ resistant xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8830c349c5785dd3c63090bf73c137a8
https://doi.org/10.1158/1078-0432.22445213
https://doi.org/10.1158/1078-0432.22445213
Autor:
Mateusz Opyrchal, Jeffrey L Salisbury, Shuya Zhang, James McCubrey, John Hawse, Mattew P Goetz, Gwen A Lomberk, Tufia Haddad, Amy Degnim, Carol Lange, James N Ingle, Evanthia Galanis, Antonino B D'Assoro
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96995 (2014)
Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are st
Externí odkaz:
https://doaj.org/article/c7da98dd6ce74f7c926be89deef9be93
Autor:
Yujiro Hayashi, David T Asuzu, Simon J Gibbons, Kirsten H Aarsvold, Michael R Bardsley, Gwen A Lomberk, Angela J Mathison, Michael L Kendrick, K Robert Shen, Takahiro Taguchi, Anu Gupta, Brian P Rubin, Jonathan A Fletcher, Gianrico Farrugia, Raul A Urrutia, Tamas Ordog
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76822 (2013)
Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine KITLG-KIT and IGF1-IG
Externí odkaz:
https://doaj.org/article/6a36f60b865849fca0e540962e4685c9