Combining affinity purification and mass spectrometry to define the network of the nuclear proteins interacting with the N-terminal region of FMRP

Autor: Félicie Kieffer, Fahd Hilal, Anne-Sophie Gay, Delphine Debayle, Marie Pronot, Gwénola Poupon, Iliona Lacagne, Barbara Bardoni, Stéphane Martin, Carole Gwizdek

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

Fragile X-Syndrome (FXS) represents the most common inherited form of intellectual disability and the leading monogenic cause of Autism Spectrum Disorders. In most cases, this disease results from the absence of expression of the protein FMRP encoded

Externí odkaz: https://doaj.org/article/41567188905949fe92005c17d4060778

Proteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat Brain

Autor: Marie Pronot, Félicie Kieffer, Anne-Sophie Gay, Delphine Debayle, Raphaël Forquet, Gwénola Poupon, Lenka Schorova, Stéphane Martin, Carole Gwizdek

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Synapses are highly specialized structures that interconnect neurons to form functional networks dedicated to neuronal communication. During brain development, synapses undergo activity-dependent rearrangements leading to both structural and function

Externí odkaz: https://doaj.org/article/12953524713c4626b238a6cd7af1dd80

Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system.

Autor: Céline Loriol, Joséphine Parisot, Gwénola Poupon, Carole Gwizdek, Stéphane Martin

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33757 (2012)

Small Ubiquitin-like MOdifier protein (SUMO) is a key regulator of nuclear functions but little is known regarding the role of the post-translational modification sumoylation outside of the nucleus, particularly in the Central Nervous System (CNS).He

Externí odkaz: https://doaj.org/article/afac2dd216a4419cb295a5621999b607

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice

Autor: Gwénola Poupon, Sara Castagnola, Sara Schiavi, Marta Prieto, Alessandra Folci, Viviana Trezza, Frédéric Brau, Emmanuel Deval, Sophie Abelanet, Carole Gwizdek, Marie Pronot, Stéphane Martin, Urielle François, Anouar Khayachi, Barbara Bardoni, Yann Humeau, Paula A. Pousinha, N. Lattuada, Maura Francolini, Magda Chafai, Valeria Buzzelli

Publikováno v: Nature Communications
Nature Communications, 2021, 12 (1), pp.1557. ⟨10.1038/s41467-021-21820-1⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.1557. ⟨10.1038/s41467-021-21820-1⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and the best-described monogenic cause of autism. CGG-repeat expansion in the FMR1 gene leads to FMR1 silencing, loss-of-expression of the Fragile X Mental Retard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3444b86dd8fac942c42a1509c4a126
https://hdl.handle.net/11590/385977

Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome

Autor: Liliana R. V. Castro, Gwénola Poupon, Małgorzata Drozd, Pierre Vincent, Stéphane Martin, Michela Servadio, Audrey Di Giorgio, Sara Schiavi, Lara Costa, Sara Castagnola, Sébastien Delhaye, Anouar Khayachi, Élia Mota, Lara Maria Sardone, Viviana Trezza, Barbara Bardoni, Stéphane Azoulay, Francesca Melancia, Marielle Jarjat, Thomas Maurin, Lucia Ciranna

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2019, 29 (8), pp.3241-3252. ⟨10.1093/cercor/bhy192⟩
Cerebral Cortex, 2019, 29 (8), pp.3241-3252. ⟨10.1093/cercor/bhy192⟩

The fragile X mental retardation protein (FMRP) is an RNA-binding protein involved in translational regulation of mRNAs that play key roles in synaptic morphology and plasticity. The functional absence of FMRP causes the fragile X syndrome (FXS), the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd061c245a05be8be5eace0153ec9c7
https://www.hal.inserm.fr/inserm-02474787