The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)

Autor: len stephens, Radenberg T, Thiel U, Vogel G, Kh, Khoo, Dell A, Tr, Jackson, Pt, Hawkins, Gw, Mayr

Publikováno v: Europe PubMed Central

A new class of inositol phosphates containing energy-rich pyrophosphoryl residues has been characterized. D/L-1-Diphosphoinositol pentakisphosphate(s) and D/L-bis-(1,4)-diphosphoinositol tetrakisphosphate(s) are present as soluble ionic species in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::119ca47c8eaff702104b69b74400c195
https://pubmed.ncbi.nlm.nih.gov/8440693

Inositol hexakisphosphate increases the size of platelet aggregates.

Autor: Brehm MA; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Klemm U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rehbach C; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany., Erdmann N; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany., Kolšek K; Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Lin H; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany., Aponte-Santamaría C; Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Gräter F; Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Rauch BH; Institute of Pharmacology, University Medicine Greifswald, Ernst-Moritz-Arndt University, Felix-Hausdorff-Str. 3, 17487 Greifswald, Germany., Riley AM; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom., Mayr GW; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany., Potter BVL; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom., Windhorst S; Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. Electronic address: s.windhorst@uke.de.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2019 Mar; Vol. 161, pp. 14-25. Date of Electronic Publication: 2018 Dec 14.

The new InsP3Kinase inhibitor BIP-4 is competitive to InsP3 and blocks proliferation and adhesion of lung cancer cells.

Autor: Schröder D; UKE Hamburg, Institut für Biochemie und Signaltransduktion, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany., Tödter K; UKE Hamburg, Institut für Biochemie und Molekular Zellbiologie, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany., Gonzalez B; Department of Crystallography and Structural Biology, Institute of Physical Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Franco-Echevarría E; Department of Crystallography and Structural Biology, Institute of Physical Chemistry Rocasolano, CSIC, Serrano 119, 28006 Madrid, Spain., Rohaly G; Heinrich-Pette-Institute Leibniz-Institute for Experimental Virology, Martinistr. 52, 20246 Hamburg, Germany., Blecher C; UKE Hamburg, Institut für Biochemie und Signaltransduktion, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany., Lin HY; UKE Hamburg, Institut für Biochemie und Signaltransduktion, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany., Mayr GW; UKE Hamburg, Institut für Biochemie und Signaltransduktion, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany., Windhorst S; UKE Hamburg, Institut für Biochemie und Signaltransduktion, UKE Hamburg, Martinistr. 52, 20246 Hamburg, Germany. Electronic address: s.windhorst@uke.de.

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Autor: Helmis C; Institut für Biochemie und Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany., Blechner C; Institut für Biochemie und Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany., Lin H; Institut für Biochemie und Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany., Schweizer M; †Center for Molecular Neurobiology Hamburg, Falkenried 94, D-20251 Hamburg, Germany., Mayr GW; Institut für Biochemie und Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany., Nielsen P; ‡Institut für Biochemie und Molekulare Zellbiologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany., Windhorst S; Institut für Biochemie und Signaltransduktion, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.

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A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA.

Autor: Brehm MA; Inositol Signaling Section, Laboratory of Signal Transduction, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA., Wundenberg T, Williams J, Mayr GW, Shears SB

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