Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gv, Gurskiĭ"'
Publikováno v:
Europe PubMed Central
Two dimeric netropsin derivatives (Lys-bis-Nt 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproducti
Autor:
Vl, Andronova, Sl, Grokhovskiĭ, An, Surovaia, Gv, Gurskiĭ, Pg, Deriabin, Vov Dk, L., Georgy Galegov
Publikováno v:
Europe PubMed Central
Using the model of an experimental cutaneous infection of guinea pig males caused by herpes simple virus type 1, it is shown that application of dimerico derivatives of netropsin Lys-bis Nt and 15Lys-bis Nt in the form of polietilenglicol-based ointm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1afac7f164baad06d440930713de7aca
http://europepmc.org/abstract/med/23785759
http://europepmc.org/abstract/med/23785759
Publikováno v:
Europe PubMed Central
The antiviral effect of combinations of netropsin derivative 15-Lys-bis-Nt with the known antiherpetic compounds, whose activity does not depend on viral TK and which are able to inhibit replication of HSV in most cases, including strains resistant t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::587b13e9b6485e9b5c01d2bc613dfda0
http://europepmc.org/abstract/med/25065145
http://europepmc.org/abstract/med/25065145
Autor:
Np, Bazhulina, An, Surovaia, Gurskiĭ IaG, Valeriya Andronova, Vs, Arkhipova, Mv, Golovkin, Am, Nikitin, Ga, Galegov, Sl, Gorokhovskiĭ, Gv, Gurskiĭ
Publikováno v:
Europe PubMed Central
Data obtained show that antiviral activities of bis-linked netropsin derivatives are targeted by specific complexes formed by helicase UL9 of herpes simplex virus type 1 with viral DNA replication origins, represented by two OriS sites and one OriL s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b71c646974f14ca49a07bd7d41de0d3f
http://europepmc.org/abstract/med/22594278
http://europepmc.org/abstract/med/22594278
Autor:
An, Surovaia, Sl, Gorohovskiĭ, Gurskiĭ IaG, Vl, Andronova, Vs, Arkhipova, Np, Bazhulina, Georgy Galegov, Gv, Gurskiĭ
Publikováno v:
Europe PubMed Central
The protein binding to the origin of replication of the herpes simplex virus type 1 (HSV-1) is DNA helicase encoded by the UL9 gene of the herpes virus. The protein specifically binds to two binding sites in the viral DNA replication origins OriS or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2165973486296dca4330225006451a38
http://europepmc.org/abstract/med/20429277
http://europepmc.org/abstract/med/20429277
Publikováno v:
Europe PubMed Central
The DNA-binding and antiviral activitus of bis-netropsins in which two monomers are attached covalently via three glycin residue were studied. These compounds have the same C-end groups but contain clusters with different numbers of lysine residues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::01123306c66eb7c8024e9bf72665e758
http://europepmc.org/abstract/med/16358781
http://europepmc.org/abstract/med/16358781
Autor:
Vl, Andronova, Sl, Grokhovskiĭ, Pg, Deriabin, Gv, Gurskiĭ, An, Surovaia, Mv, Jas Ko, Mk, Kukhanova, Sn, Kochetkov, Skoblov IuS, Georgy Galegov
Publikováno v:
Europe PubMed Central
Antiherpetic activity of the double and triple combinations, including original connections 15Lys-bis-Nt and phosphate of acycloguanosine (P-ACG), was studied in vitro. For the first time, it was demonstrated that in case of their combined use with k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cfc68ccad7b64712da66af819b6167f1
http://europepmc.org/abstract/med/25549466
http://europepmc.org/abstract/med/25549466
Autor:
Andronova VL, Grokhovskiĭ SL, Deriabin PG, Gurskiĭ GV, Surovaia AN, Jas'ko MV, Kukhanova MK, Kochetkov SN, Skoblov IuS, Galegov GA
Publikováno v:
Voprosy virusologii [Vopr Virusol] 2014 Jul-Aug; Vol. 59 (4), pp. 37-41.
Publikováno v:
Voprosy virusologii [Vopr Virusol] 2014 Jan-Feb; Vol. 59 (1), pp. 38-41.
Publikováno v:
Voprosy virusologii [Vopr Virusol] 2013 Jan-Feb; Vol. 58 (1), pp. 32-5.