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Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies.

Autor: Yoon YM; University of Chicago, Department of Medicine, Chicago, IL 60637., Velez TE; University of Virginia, Department of Medicine, Charlottesville, VA 22908., Upadhyay V; University of California San Francisco, Department of Medicine, San Francisco, CA 94143., Vazquez SE; University of California San Francisco and Chan Zuckerberg Biohub, San Francisco, CA 94158., Lee CT; University of Chicago, Department of Medicine, Chicago, IL 60637., Selvan KC; University of Chicago, Department of Medicine, Chicago, IL 60637., Law CS; University of California San Francisco, Department of Medicine, San Francisco, CA 94143., Blaine KM; University of Chicago, Department of Medicine, Chicago, IL 60637., Hollinger MK; University of Chicago, Department of Medicine, Chicago, IL 60637.; University of Virginia, Department of Medicine, Charlottesville, VA 22908., Decker DC; University of Chicago, Department of Medicine, Chicago, IL 60637., Clark MR; University of Chicago, Department of Medicine, Chicago, IL 60637., Strek ME; University of Chicago, Department of Medicine, Chicago, IL 60637., Guzy RD; University of Wisconsin at Madison, Department of Medicine, Madison, WI 53792., Adegunsoye A; University of Chicago, Department of Medicine, Chicago, IL 60637., Noth I; University of Virginia, Department of Medicine, Charlottesville, VA 22908., Wolters PJ; University of California San Francisco, Department of Medicine, San Francisco, CA 94143., Anderson M; University of California San Francisco, Department of Medicine, San Francisco, CA 94143., DeRisi JL; University of California San Francisco and Chan Zuckerberg Biohub, San Francisco, CA 94158., Shum AK; University of California San Francisco, Department of Medicine, San Francisco, CA 94143., Sperling AI; University of Chicago, Department of Medicine, Chicago, IL 60637.; University of Virginia, Department of Medicine, Charlottesville, VA 22908.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 May 11. Date of Electronic Publication: 2023 May 11.

Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.

Autor: Lee TH; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Yeh CF; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan., Lee YT; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Shih YC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Chen YT; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Hung CT; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., You MY; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Wu PC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Shentu TP; Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA., Huang RT; Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA., Lin YS; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Wu YF; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan., Lin SJ; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.; Department of Dermatology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan., Lu FL; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Tsao PN; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Lin TH; Material and Chemical Research Laboratories, Industrial Technology Research Institute, Zhudong, Taiwan., Lo SC; Material and Chemical Research Laboratories, Industrial Technology Research Institute, Zhudong, Taiwan., Tseng YS; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Wu WL; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Chen CN; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan., Wu CC; Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan.; Department and Graduate Institute of Medical Education & Bioethics, National Taiwan University College of Medicine, Taipei, Taiwan., Lin SL; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.; Department and Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Sperling AI; Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA., Guzy RD; Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA., Fang Y; Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL, USA., Yang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan. kcyang@ntu.edu.tw.; Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan. kcyang@ntu.edu.tw.; Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan. kcyang@ntu.edu.tw.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. kcyang@ntu.edu.tw.

Publikováno v: Nature communications [Nat Commun] 2020 Aug 26; Vol. 11 (1), pp. 4254. Date of Electronic Publication: 2020 Aug 26.

FGFR2 Is Required for AEC2 Homeostasis and Survival after Bleomycin-induced Lung Injury.

Autor: Dorry SJ; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; and., Ansbro BO; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; and., Ornitz DM; Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri., Mutlu GM; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; and., Guzy RD; Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois; and.

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2020 May; Vol. 62 (5), pp. 608-621.

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.

Autor: Reyfman PA; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Walter JM; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Joshi N; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Anekalla KR; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., McQuattie-Pimentel AC; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Chiu S; 2 Division of Thoracic Surgery, Department of Surgery., Fernandez R; 2 Division of Thoracic Surgery, Department of Surgery., Akbarpour M; 2 Division of Thoracic Surgery, Department of Surgery., Chen CI; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Ren Z; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Verma R; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Abdala-Valencia H; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Nam K; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Chi M; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Han S; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Gonzalez-Gonzalez FJ; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Soberanes S; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Watanabe S; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Williams KJN; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Flozak AS; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Nicholson TT; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Morgan VK; 3 Division of Rheumatology, Department of Medicine., Winter DR; 3 Division of Rheumatology, Department of Medicine., Hinchcliff M; 3 Division of Rheumatology, Department of Medicine., Hrusch CL; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Guzy RD; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Bonham CA; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Sperling AI; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Bag R; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Hamanaka RB; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Mutlu GM; 4 Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois; and., Yeldandi AV; 5 Department of Pathology, and., Marshall SA; 6 Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Shilatifard A; 6 Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Amaral LAN; 7 Department of Chemical and Biological Engineering, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois., Perlman H; 3 Division of Rheumatology, Department of Medicine., Sznajder JI; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Argento AC; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.; 2 Division of Thoracic Surgery, Department of Surgery., Gillespie CT; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.; 2 Division of Thoracic Surgery, Department of Surgery., Dematte J; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Jain M; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Singer BD; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.; 6 Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Ridge KM; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Lam AP; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Bharat A; 2 Division of Thoracic Surgery, Department of Surgery., Bhorade SM; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Gottardi CJ; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Budinger GRS; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine., Misharin AV; 1 Division of Pulmonary and Critical Care Medicine, Department of Medicine.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Jun 15; Vol. 199 (12), pp. 1517-1536.