Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold

Autor: Smith III, Amos B. ^*, Favor, David A., Sprengeler, Paul A., Guzman, Mark C., Carroll, Patrick J., Furst, George T., Hirschmann, Ralph ^*

Publikováno v: In Bioorganic & Medicinal Chemistry January 1999 7(1):9-22

Design and synthesis of nonpeptide peptidomimetic inhibitors of renin.

Autor: Smith, Amos B., Akaishi, Ryouichi, Jones, David R., Keenam, Terence P., Guzman, Mark C., Holcomb, Ryan C., Sprengeler, Paul A., Wood, John L., Hirschmann, Ralph, Holloway, M. Katharine

Publikováno v: Biopolymers; 1995, Vol. 37 Issue 1, p29-53, 25p

An effective synthesis of scalemic 3,5,5-trisubstituted pyrrolin-4-ones

Autor: Smith, Amos B., III, Holcomb, Ryan C., Guzman, Mark C., Keenan, Terence P., Sprengeler, Paul A., Hirschmann, Ralph

Publikováno v: In Tetrahedron Letters 1993 34(1):63-66

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.

Autor: Dragovich PS; Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals, Inc., 10777 Science Center Drive, San Diego, California 92121-1111, USA. peter.dragvich@pfizer.com, Prins TJ, Zhou R, Brown EL, Maldonado FC, Fuhrman SA, Zalman LS, Tuntland T, Lee CA, Patick AK, Matthews DA, Hendrickson TF, Kosa MB, Liu B, Batugo MR, Gleeson JP, Sakata SK, Chen L, Guzman MC, Meador JW 3rd, Ferre RA, Worland ST

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Apr 11; Vol. 45 (8), pp. 1607-23.