Sodium channel haploinsufficiency and structural change in ventricular arrhythmogenesis.

Autor: Jeevaratnam, K.^1,2, Guzadhur, L.^3,4, Goh, Y. M.⁵, Grace, A. A.³, Huang, C. L.‐H.^3,6

Publikováno v: Acta Physiologica. Feb2016, Vol. 216 Issue 2, p186-202. 17p. 2 Diagrams, 3 Graphs.

Arrhythmic substrate, slowed propagation and increased dispersion in conduction direction in the right ventricular outflow tract of murine Scn5a+/− hearts.

Autor: Zhang, Y.^1,2, Guzadhur, L.¹, Jeevaratnam, K.^1,3, Salvage, S. C.¹, Matthews, G. D. K.¹, Lammers, W. J.⁴, Lei, M.⁵, Huang, C. L.‐H.^1,6, Fraser, J. A.¹

Publikováno v: Acta Physiologica. Aug2014, Vol. 211 Issue 4, p559-573. 15p. 2 Diagrams, 1 Chart, 4 Graphs.

Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts

Autor: Salvage, SC, King, JH, Chandrasekharan, KH, Jafferji, DIG, Guzadhur, L, Matthews, HR, Huang, CL-H, Fraser, JA

AIMS: Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Nav 1.5 curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::bb3c9cf47a8cd840ec89873019f6cd58
https://www.repository.cam.ac.uk/handle/1810/248079

Altered re-excitation thresholds and conduction of extrasystolic action potentials contribute to arrhythmogenicity in murine models of long QT syndrome

Autor: Duehmke , RM, Pearcey, S, Stefaniak, JD, Guzadhur , L, Jeevaratnam , K, Costopoulos , C, Pedersen, Thomas Holm, Grace , AA, Huang, CL

Publikováno v: Duehmke, RM, Pearcey, S, Stefaniak, JD, Guzadhur, L, Jeevaratnam, K, Costopoulos, C, Pedersen, T H, Grace, AA & Huang, CL 2012, ' Altered re-excitation thresholds and conduction of extrasystolic action potentials contribute to arrhythmogenicity in murine models of long QT syndrome. ', Acta Physiologica
, vol. 206, no. 3, pp. 164-177 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::8844eaf0e05c4ce685100730f6b03b50
https://pure.au.dk/portal/da/publications/altered-reexcitation-thresholds-and-conduction-of-extrasystolic-action-potentials-contribute-to-arrhythmogenicity-in-murine-models-of-long-qt-syndrome(1fecdda3-b1f7-4e2e-9aac-3a65a69fe5b6).html

E Right ventricular origin of arrhythmias inScn5a+/− mice is due to reduced Na+ and higher K+ channel expression and function

Autor: C Schwiening, James E. Cartledge, C L-H Huang, K Kemmerich, Jason Lawrence, U Siedlecka, Claire Martin, Nicola Brice, Andrew A. Grace, Guzadhur L, Cesare M. Terracciano

Publikováno v: Heart. 98:A2.2-A3

Introduction Brugada syndrome is associated with ventricular tachycardia originating in the right ventricle (RV); this has been attributed to either depolarisation abnormalities or increased repolarisation heterogeneities. We have used a heterozygoti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2e0caeeb977c9215f611aea1b061f62
https://doi.org/10.1136/heartjnl-2012-301877a.5