Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model.

Autor: Disdier C; CERES BRAIN THERAPEUTICS, ICM, Hôpital Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France., Soyer A; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Broca-Brisson L; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, LENIT, Gif-sur-Yvette, Cedex 91191, France., Goutal S; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Guyot AC; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, LENIT, Gif-sur-Yvette, Cedex 91191, France., Ziani N; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Breuil L; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Winkeler A; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Hugon G; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Joudinaud T; CERES BRAIN THERAPEUTICS, ICM, Hôpital Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France., Bénech H; CERES BRAIN THERAPEUTICS, ICM, Hôpital Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France., Armengaud J; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, LI2D, 30200 Bagnols-sur-Cèze, France., Skelton MR; Department of Pediatrics, University of Cincinnati College of Medicine and Division of Neurology, Cincinnati Children's Research Foundation, United States., Harati R; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, 27272 Sharjah, United Arab Emirates., Hamoudi RA; Clinical Sciences Department, College of Medicine, University of Sharjah, 27272 Sharjah, United Arab Emirates; Division of Surgery and Interventional Science, University College London, London, United Kingdom., Tournier N; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France., Mabondzo A; CERES BRAIN THERAPEUTICS, ICM, Hôpital Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75013 Paris, France; Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), SPI, LENIT, Gif-sur-Yvette, Cedex 91191, France. Electronic address: aloise.mabondzo@cea.fr.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2024 Nov; Vol. 202, pp. 106720. Date of Electronic Publication: 2024 Oct 26.

Dodecyl creatine ester improves cognitive function and identifies key protein drivers including KIF1A and PLCB1 in a mouse model of creatine transporter deficiency.

Autor: Mabondzo A; Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France., Harati R; Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharja, Sharjah, United Arab Emirates.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates., Broca-Brisson L; Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France., Guyot AC; Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France., Costa N; Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (MTS), Gif sur Yvette, France., Cacciante F; Institute of Neuroscience, National Research Council (CNR), Pisa, Italy., Putignano E; Institute of Neuroscience, National Research Council (CNR), Pisa, Italy., Baroncelli L; Institute of Neuroscience, National Research Council (CNR), Pisa, Italy.; Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy., Skelton MR; Department of Pediatrics, University of Cincinnati College of Medicine and Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, OH, United States., Saab C; Université de Paris and Université Paris Saclay, CEA, Stabilité Génétique Cellules Souches et Radiations, Fontenay aux Roses, France., Martini E; Université de Paris and Université Paris Saclay, CEA, Stabilité Génétique Cellules Souches et Radiations, Fontenay aux Roses, France., Benech H; Ceres Brain Therapeutics, Paris, France., Joudinaud T; Ceres Brain Therapeutics, Paris, France., Gaillard JC; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé (MTS), INRAE, Bagnol sur Cèze, France., Armengaud J; Université Paris Saclay, CEA, Département Médicaments et Technologies pour la Santé (MTS), INRAE, Bagnol sur Cèze, France., Hamoudi R; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates.; Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.; Division of Surgery and Interventional Science, University College London, London, United Kingdom.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2023 Mar 24; Vol. 16, pp. 1118707. Date of Electronic Publication: 2023 Mar 24 (Print Publication: 2023).

A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.

Autor: Guyot AC; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Leuxe C; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Disdier C; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France.; Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Warren Alpert Medical School, Brown University, Providence, RI, USA., Oumata N; University Paris Descartes, INSERM U1022, 4, avenue de l'Observatoire, 75006, Paris, France., Costa N; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Roux GL; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Varela PF; Institute for Integrative Biology of the Cell: Department of Biochemistry, Biophysics and Structural Biology,CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Duchon A; Université de Strasbourg, CNRS, INSERM, IGBMC, 1 rue Laurent Fries, 67404, Illkirch, France., Charbonnier JB; Institute for Integrative Biology of the Cell: Department of Biochemistry, Biophysics and Structural Biology,CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France., Herault Y; Université de Strasbourg, CNRS, INSERM, IGBMC, 1 rue Laurent Fries, 67404, Illkirch, France., Pavoni S; Service d'Etude des Prions et Infections Atypiques (SEPIA), Institut François Jacob, CEA, Université Paris-Saclay, Fontenay-aux-Roses, France., Galons H; University Paris Descartes, INSERM U1022, 4, avenue de l'Observatoire, 75006, Paris, France., Andriambeloson E; Neurofit, 67400, Illkirch, France., Wagner S; Neurofit, 67400, Illkirch, France., Meijer L; Perha-pharma, Centre de Perharidy, Roscoff, France., Lund AK; Department of Biological Sciences, Advanced Environmental Research Institute, University of North Texas, Denton, TX, USA., Mabondzo A; Service de Pharmacologie et d'Immunoanalyse, CEA, Université Paris-Saclay, F-91191, Gif-sur Yvette, France. aloise.mabondzo@cea.fr.

Publikováno v: Scientific reports [Sci Rep] 2020 Jan 24; Vol. 10 (1), pp. 1143. Date of Electronic Publication: 2020 Jan 24.

Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice.

Autor: Oppenheim HA, Lucero J, Guyot AC, Herbert LM, McDonald JD, Mabondzo A, Lund AK; Environmental Respiratory Health Program, Lovelace Respiratory Research Institute, Albuquerque, NM,USA. amie.lund@unt.edu.

Publikováno v: Particle and fibre toxicology [Part Fibre Toxicol] 2013 Dec 17; Vol. 10, pp. 62. Date of Electronic Publication: 2013 Dec 17.

In vitro primary human and animal cell-based blood-brain barrier models as a screening tool in drug discovery.

Autor: Lacombe O; Laboratoires Fournier S.A., Daix, France., Videau O, Chevillon D, Guyot AC, Contreras C, Blondel S, Nicolas L, Ghettas A, Bénech H, Thevenot E, Pruvost A, Bolze S, Krzaczkowski L, Prévost C, Mabondzo A

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2011 Jun 06; Vol. 8 (3), pp. 651-63. Date of Electronic Publication: 2011 Apr 15.