Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Guylaine Benoit"'
Autor:
Jamey D. Marth, Jing-Qi Huang, Daniel Phaneuf, Alan C. Peterson, Anita Borowski, Guylaine Benoit, Beverly R. Akerman, Gerd Ritter, Carlos R. Morales, Daniel Leclerc, Roy A. Gravel, Nobuaki Wakamatsu, Suleiman A. Igdoura, Nobuo Hanai, Jacquetta M. Trasler, Sheila R. Fortunato
Publikováno v:
Human Molecular Genetics. 5:1-14
We have generated mouse models of human Tay-Sachs and Sandhoff diseases by targeted disruption of the Hexa (alpha subunit) or Hexb (beta subunit) genes, respectively, encoding lysosomal beta-hexosaminidase A (structure, alpha) and B (structure, beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490d48908ff3c1edb11493e12a23a512
https://doi.org/10.1093/hmg/5.1.1
https://doi.org/10.1093/hmg/5.1.1
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1227:79-86
The murine HEXB gene, encoding the β-subunit of the lysosomal hydrolase, β-hexosaminidase, was isolated from a mouse cosmid library as a single cosmid clone. The entire gene spans 22 kb, considerably less than the 40 kb spanned by its human counter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d56c9584962b0a7747fdf6703640709
https://doi.org/10.1016/0925-4439(94)90110-4
https://doi.org/10.1016/0925-4439(94)90110-4
Autor:
Guylaine Benoit, Jacquetta M. Trasler
Publikováno v:
Biology of Reproduction. 50:1312-1319
Sex- and sequence-specific patterns of methylation of mammalian DNA are established during gametogenesis and are believed to be important for genomic imprinting and developmental gene regulation. DNA methylation in mammalian cells is performed predom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e8f1ff9430aac5d0ab8dd99e6e423c
https://doi.org/10.1095/biolreprod50.6.1312
https://doi.org/10.1095/biolreprod50.6.1312
Publikováno v:
Endocrinology. 141(9)
Genomic methylation patterns originate during gametogenesis and are postulated to be involved in important developmental events, including gene regulation, embryogenesis, and genomic imprinting. In previous work, treatment of male rats with 5-azacyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cf11e752ca93be6129957830e647ea
https://pubmed.ncbi.nlm.nih.gov/10965894
https://pubmed.ncbi.nlm.nih.gov/10965894
Publikováno v:
Biology of reproduction. 52(6)
Changes in DNA methylation patterns during gametogenesis have been implicated in the regulation of germ cell development and genomic imprinting. Cytosine methylation is catalyzed by the enzyme DNA (cytosine-5)-methyltransferase (DNA MTase). The objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5024a3ae8dc4faad5b4cc24edbc1ff2
https://pubmed.ncbi.nlm.nih.gov/7632844
https://pubmed.ncbi.nlm.nih.gov/7632844
Autor:
Jacquetta M. Trasler, Guylaine Benoit, Nobuaki Wakamatsu, Roy A. Gravel, Zhi-Xin Zhang, Barbara Triggs-Raine, Anne-Marie Lamhonwah
Publikováno v:
Genomics. 24(1)
Genomic clones of the mouse HEXA gene encoding the alpha subunit of lysosomal beta-hexosaminidase A have been isolated, analyzed, and sequenced. The HEXA gene spans approximately 26 kb and consists of 14 exons and 13 introns. The 5' flanking region o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8694f1e68dc37df0bf2218f94fe6141
https://pubmed.ncbi.nlm.nih.gov/7896264
https://pubmed.ncbi.nlm.nih.gov/7896264