Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury

Autor: Elena A. Konnova, Alexandru-Florian Deftu, Paul Chu Sin Chung, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd, Marc R. Suter

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 21, p 15559 (2023)

Satellite glial cells (SGCs), enveloping primary sensory neurons’ somas in the dorsal root ganglion (DRG), contribute to neuropathic pain upon nerve injury. Glial fibrillary acidic protein (GFAP) serves as an SGC activation marker, though its DRG s

Externí odkaz: https://doaj.org/article/26e4933f806e43f59527a1eb7f1bbc07

Spinal Cord T-Cell Infiltration in the Rat Spared Nerve Injury Model: A Time Course Study

Autor: Christophe Gattlen, Christine B. Clarke, Nicolas Piller, Guylène Kirschmann, Marie Pertin, Isabelle Decosterd, Romain-Daniel Gosselin, Marc R. Suter

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 3, p 352 (2016)

The immune system is involved in the development of neuropathic pain. In particular, the infiltration of T-lymphocytes into the spinal cord following peripheral nerve injury has been described as a contributor to sensory hypersensitivity. We used the

Externí odkaz: https://doaj.org/article/a5d5c250545541149c01c17cf8429535

Reversing anterior insular cortex neuronal hypoexcitability attenuates compulsive behavior in juvenile rats

Autor: Isabelle Decosterd, Kshitij S. Jadhav, Alexander F. Hoffman, Guylène Kirschmann, Carl R. Lupica, Léa Aeschlimann, Benjamin Boutrel, Aurélien P. Bernheim

Development of self-regulatory competencies during adolescence is partially dependent on normative brain maturation. Here we report that juvenile rats as compared to adults exhibit impulsive and compulsive-like behavioral traits, the latter being ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d52022e919772d2da820c0fdc8e43b1
https://doi.org/10.1101/2021.10.28.466154

Rufinamide Attenuates Mechanical Allodynia in a Model of Neuropathic Pain in the Mouse and Stabilizes Voltage-gated Sodium Channel Inactivated State

Autor: Marc R Suter, Hugues Abriel, Isabelle Decosterd, Guylène Kirschmann, Cédric J. Laedermann

Publikováno v: Anesthesiology, vol. 118, no. 1, pp. 160-172
Anesthesiology

BACKGROUND:: Voltage-gated sodium channels dysregulation is important for hyperexcitability leading to pain persistence. Sodium channel blockers currently used to treat neuropathic pain are poorly tolerated. Getting new molecules to clinical use is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613200032c59847fb04a259d4de58c96
https://doi.org/10.1097/aln.0b013e318278cade

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

Autor: Marie Pertin, Hugues Abriel, Maxime Albesa, Isabelle Decosterd, Romain-Daniel Gosselin, M. Cachemaille, Guylène Kirschmann, Cédric J. Laedermann, Chris Towne, Stephan Kellenberger, Bernard L. Schneider, Isabelle Chang

Publikováno v: The Journal of clinical investigation
Journal of Clinical Investigation, vol. 123, no. 7, pp. 3002-3013
Laedermann, Cédric; Cachemaille, Matthieu; Kirschmann, Guylène; Pertin, Marie; Gosselin, Romain-Daniel; Chang, Isabelle; Albesa, Maxime; Towne, Chris; Schneider, Bernard L.; Kellenberger, Stephan; Abriel, Hugues; Decosterd, Isabelle (2013). Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. Journal of clinical investigation, 123(7), pp. 3002-3013. American Society for Clinical Investigation 10.1172/JCI68996

Peripheral neuropathic pain is a disabling condition resulting from nerve injury. It is characterized by the dysregulation of voltage-gated sodium channels (Na(v)s) expressed in dorsal root ganglion (DRG) sensory neurons. The mechanisms underlying th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db0dc7978336f0f13aa5486d05068e8
https://europepmc.org/articles/PMC3696561/