Preclinical Testing of Dendritic Core–Multishell Nanoparticles in Inflammatory Skin Equivalents

Autor: Patrick Graff, Stefan Hönzke, Aaroh Anand Joshi, Guy Yealland, Emanuel Fleige, Michael Unbehauen, Monika Schäfer-Korting, Andreas Hocke, Rainer Haag, Sarah Hedtrich

Publikováno v: Molecular Pharmaceutics. 19:1795-1802

Human skin equivalents emerged as novel tools in preclinical dermatological research. It is being claimed that they may bridge the translational gap between preclinical and clinical research, yet only a few studies have investigated their suitability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9822999d8da0b8db9dd550cbe442244
https://doi.org/10.1021/acs.molpharmaceut.1c00734

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells

Autor: Fabian Schumacher, Alexander Edlich, Christian Gerecke, Alexandra Wetzel, Thomas Homann, Bettina Scholtka, Burkhard Kleuser, Guy Yealland, Lena Katharina Neubert

Publikováno v: Oncotarget. 9:32822-32840

Epigenetic silencing of tumour suppressor genes is a key hallmark of colorectal carcinogenesis. Despite this, the therapeutic potential of epigenetic agents capable of reactivating these silenced genes remains relatively unexplored. Evidence has show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd5d0493cb492e9168d34d9bdb5e1ad
https://doi.org/10.18632/oncotarget.25999

Effect of Delivery Platforms Structure on the Epidermal Antigen Transport for Topical Vaccination

Autor: Luis Marcelino Gugliotta, Guy Yealland, Mrityunjoy Kar, Marcelo Calderón, Verónica Doris Guadalupe González, Roque Javier Minari, Sarah Hedtrich, Stefanie Wedepohl, Ana Sofía Sonzogni

Transdermal immunization is highly attractive because of the skin's accessibility and unique immunological characteristics. However, it remains a relatively unexplored route of administration because of the great difficulty of transporting antigens p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8dea278aabe4da4be3ae86200b6f8c
http://pubs.acs.org/doi/10.1021/acs.biomac.8b01307

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

Autor: Nan Zhang, Nan Ma, Christian Gerecke, Silke B. Lohan, Sarah Hedtrich, Monika Schäfer-Korting, Fabian Schumacher, Martina C. Meinke, Burkhard Kleuser, Alexander Edlich, Falko Neumann, Michael Giulbudagian, André Said, Marcelo Calderón, Guy Yealland

Publikováno v: Gerecke, C.; Edlich, A.; Giulbudagian, M.; Schumacher, F.; Zhang, N.; Said, A.; Yealland, G.; Lohan, S.B.; Neumann, F.; Meinke, M.C.; Ma, N.; Calderon, M.; Hedtrich, S.; Schaefer-Korting, M.; Kleuser, B.: Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes. In: Nanotoxicology . Vol. 11 (2017) 2, 267-277. (DOI: 10.1080/17435390.2017.1292371)

Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49726c9fa44f1ab9202f54af21cd91f5

Nanogel-Mediated Protein Replacement Therapy for Autosomal Recessive Congenital Ichthyosis (ARCI)

Autor: Guy Yealland, Katja Obst, Hans Christian Hennies, Marcelo Calderón, Katja Martina Eckl, Roswitha Plank, Sarah Hedtrich

Publikováno v: Proceedings of the World Congress on Recent Advances in Nanotechnology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f826a0561a3c25a018857a3dcb161126
https://doi.org/10.11159/nddte16.105