Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Guy Y. Krippner"'
Autor:
Karlheinz Peter, Dietmar A. Plattner, Guy Y. Krippner, Steffen U. Eisenhardt, Bernhard Breit, Johannes Zeller, Michel Kather, Sheena Kreuzaler, Bernd Kammerer
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1186
CRP is an important mediator of the inflammatory response. Pro-inflammatory CRP effects are mediated by pCRP* and mCRP, dissociation products of the native pCRP. The concentration of pCRP during inflammation may rise up to concentrations 1,000-fold f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31e57ddca43b18757e922f3bcd6b71e
https://pubmed.ncbi.nlm.nih.gov/34798417
https://pubmed.ncbi.nlm.nih.gov/34798417
Autor:
Pacific Huynh, Zhonglin Chai, Aozhi Dai, Shuting Ren, Frank Koentgen, Mark E. Cooper, Guy Y. Krippner, Tieqiao Wu
Publikováno v:
Diabetes. 68:395-408
Targeting cell division autoantigen 1 (CDA1) is postulated to attenuate the profibrotic actions of transforming growth factor-β in diabetic nephropathy. This study has identified a regulatory protein for CDA1 and has then used genetic and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a453fb12b96928686fa0f09ebf3594
https://doi.org/10.2337/db18-0712
https://doi.org/10.2337/db18-0712
Autor:
Elizabeth A. Vecchio, Lauren T. May, Jonathan B. Baell, Silvia C. Teguh, Guy Y. Krippner, Ryan Brady, Daniel L. Priebbenow, Chengxue Qin, Julia G. Beveridge, Minh Deo, Rebecca H. Ritchie, Girdhar Singh Deora, Aaron DeBono
Publikováno v:
Journal of medicinal chemistry. 62(10)
Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa513b09b2bac30b32f32192bb26f594
https://pubmed.ncbi.nlm.nih.gov/31038950
https://pubmed.ncbi.nlm.nih.gov/31038950
Autor:
Michael J Kraakman, Christoph Garbers, Tamara L Allen, Darren C. Henstridge, Mark A. Febbraio, Helene L. Kammoun, Lena Cron, Amanda E. Brandon, Casey L. Egan, Emma Estevez, James Sligar, Paul A. Baldock, Clinton R. Bruce, Guy Y. Krippner, Trevor J. Biden, Damien J. Keating, Emily W. Sun, Gregory J. Cooney, Martin Pal, Stefan Rose-John, Timothy E. Adams, Peter J. Meikle, Richard L. Young, Natalie A. Mellet, Greg M. Kowalski, Joachim Grötzinger, Michael A. Cowley, Laurie L. Baggio, Steve Risis, Liam O’Reilly, Robert S. Lee, Kevin I. Watt, Paul Gregorevic, Erica Kimber, Maria Findeisen, Christine Yang, Le May Thai, Daniel J. Drucker
Publikováno v:
Nature. 574(7776)
The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of type 2 diabetes. Accordingly, we engineered the gp130 ligand IC7Fc, in which one gp130-binding site is removed from IL-6 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e0efe2a7ab40399e02ad90bfc37940
https://pubmed.ncbi.nlm.nih.gov/31673130
https://pubmed.ncbi.nlm.nih.gov/31673130
Autor:
Karlheinz Peter, Paul S. Donnelly, Guy Y. Krippner, Karen Alt, Stan Poniger, Brett M. Paterson, Katie Ardipradja, Henri Tochon-Danguy, Ashish Kumar Narayan Nair, Schweta Jagdale, Erik Westein, Stacey E Rudd, Xiaowei Wang, Timothy U. Connell, Christoph E. Hagemeyer
Publikováno v:
Angewandte Chemie International Edition. 54:7515-7519
A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic bioconjugation with the transpeptidase Sortase A for incorporation of strained cyclooctyne functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38583997836bbf72e702e2336af33b87
https://doi.org/10.1002/anie.201411507
https://doi.org/10.1002/anie.201411507
Autor:
Vicky A. Burgess, Stephen G. Davies, Mark Whittaker, K. H. Sutton, Paul Beckett, Guy Y. Krippner
In solution reglo- and stereoselective additions of nucleophiles to (RS)-[(η5-C5H5)Fe(CO)(PPh3)CO-3- pyridyl] (1) occur at C-4 to give the corresponding nitrogen-stabilised anions. Subsequent quenching of these anions by a proton, a chloroformate or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7861c1520a9e6b6407fb347736a6ac
https://ora.ox.ac.uk/objects/uuid:fa8f4af7-2020-41e7-ab90-cbf15a4228ce
https://ora.ox.ac.uk/objects/uuid:fa8f4af7-2020-41e7-ab90-cbf15a4228ce
Autor:
Juan Carlos Molero, Victoria C. Foletta, Nicky Konstantopoulos, Stephen Wanyonyi, Adrian Cooper, Guy Y. Krippner, Timothy Connor, Briana Spolding, Courtney Swinton, Ken Walder, Sean L. McGee, Sofianos Andrikopoulos, Sharon Jones, R. Fahey, Shona Morrison, Melissa de Vries, Lucía García-Guerra
Publikováno v:
Diabetes
We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro. The effects of these compounds were investigated in diabetic db/db mice, insulin-resistant diet-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3c99a4b41759527d27bfa64be54e0b
https://doi.org/10.2337/db11-0578
https://doi.org/10.2337/db11-0578
Autor:
Richard J. Simpson, Robert MacGinley, Geoffrey C. Nicholson, Kerrie M. Sanders, Kathy Skoff, Ken Walder, Neil Orford, Guy Y. Krippner, Alana Sarah, Joseph Proietto, Gabrielle Phillips, Vincent J Wacher, Jo Chambers
Publikováno v:
Diabetes Care. 37:3121-3123
OBJECTIVE To evaluate the safety and efficacy of methazolamide as a potential therapy for type 2 diabetes. RESEARCH DESIGN AND METHODS This double-blind, placebo-controlled study randomized 76 patients to oral methazolamide (40 mg b.i.d.) or placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1abda875ba7b25d9f7acab53a3b514
https://doi.org/10.2337/dc14-1038
https://doi.org/10.2337/dc14-1038
Publikováno v:
Macromolecules. 42:2784-2794
We have used molecular dynamics simulations to study the structures of a range of heterogeneously functionalized (“variegated”) dendrimers and the distributions in space of their caps. By a virtual capping approach, we compare an asymmetric dendr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006c6b98ccc052d1783057592302eec4
https://doi.org/10.1021/ma8021579
https://doi.org/10.1021/ma8021579
Publikováno v:
Macromolecules. 42:2775-2783
We have used atomistic molecular dynamics simulations to study the molecular-scale structure of poly(l-lysine) dendrimers homogeneously functionalized with naphthalene disulfonate caps from the first generation to the sixth generation. These dendrime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2006887f43dee290995bba1b34cf106
https://doi.org/10.1021/ma802154e
https://doi.org/10.1021/ma802154e