Data in support of a harmine-derived beta-carboline in vitro effects in cancer cells through protein synthesis

Autor: Annelise Carvalho, Jennifer Chu, Céline Meinguet, Robert Kiss, Guy Vandenbussche, Bernard Masereel, Johan Wouters, Alexander Kornienko, Jerry Pelletier, Véronique Mathieu

Publikováno v: Data in Brief, Vol 12, Iss C, Pp 546-551 (2017)

A harmine-derived beta-carboline, CM16, inhibits cancer cells growth through its effects on protein synthesis, as described in “A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis” (Carvalho et al

Externí odkaz: https://doaj.org/article/e46aa951c8874a4e96b41302feff1398

The quiescin sulfhydryl oxidase (hQSOX1b) tunes the expression of resistin-like molecule alpha (RELM-α or mFIZZ1) in a wheat germ cell-free extract.

Autor: Wael Gad, Meera G Nair, Karolien Van Belle, Khadija Wahni, Henri De Greve, Jo A Van Ginderachter, Guy Vandenbussche, Yaeta Endo, David Artis, Joris Messens

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e55621 (2013)

Although disulfide bond formation in proteins is one of the most common types of post-translational modifications, the production of recombinant disulfide-rich proteins remains a challenge. The most popular host for recombinant protein production is

Externí odkaz: https://doaj.org/article/8a2edffed15b470da5ebc1ccde9f4838

Targeting an Intrinsically Disordered Protein by Covalent Modification

Autor: Hung Huy, Nguyen, Péter, Ábrányi-Balogh, László, Petri, Attila, Mészáros, Kris, Pauwels, Guy, Vandenbussche, György Miklós, Keserű, Peter, Tompa

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2141

Intrinsically disordered proteins (IDPs) play important roles in the regulation of cellular function and in disease, and thus they represent an important group of therapeutic targets. Yet, members of this "disorderome" have not yet been successfully

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::deda5c078288d073b3f09d92135b28a6
https://pubmed.ncbi.nlm.nih.gov/32696392

A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis

Autor: Jennifer Chu, Annelise De Carvalho, Bernard Masereel, Robert Kiss, Céline Meinguet, Guy Vandenbussche, Johan Wouters, Véronique Mathieu, Alexander Kornienko, Jerry Pelletier

Publikováno v: Carvalho, A, Chu, J, Meinguet, C, Kiss, R, Vandenbussche, G, Masereel, B, Wouters, J, Kornienko, A, Pelletier, J & Mathieu, V 2017, ' A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis ', European Journal of Pharmacology, vol. 805, pp. 25-35 . https://doi.org/10.1016/j.ejphar.2017.03.034

Growing evidence indicates that protein synthesis is deregulated in cancer onset and progression and targeting this process might be a selective way to combat cancers. While harmine is known to inhibit DYRK1A and intercalate into the DNA, tri-substit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8222dd162259798b461077c3cdb9a71
https://doi.org/10.1016/j.ejphar.2017.03.034

A new potential anti-cancer beta-carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation

Autor: Kris De Braekeleer, Johan Wouters, Pierre Van Antwerpen, Véronique Mathieu, Johan Viaene, Florence Souard, Cédric Delporte, Bernard Masereel, Guy Vandenbussche, Yvan Vander Heyden, Annelise De Carvalho

Publikováno v: Drug development research, 8 (1

Gliomas remain highly fatal due to their high resistance to current therapies. Deregulation of protein synthesis contributes to cancer onset and progression and is a source of rising interest for new drugs. CM16, a harmine derivative with predicted h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9210ab2ef41c64ea4530730ba9e8bb
https://pubmed.ncbi.nlm.nih.gov/31498913