Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Guy Van Lommen"'
Autor:
Guido Verniest, Christel Jeanne Marie Menet, Guy Van Lommen, Ann De Blieck, Johan Wouters, Ben Schurgers
Publikováno v:
European Journal of Organic Chemistry. 2019:36-40
Autor:
R Galien, Raphael Geney, Koen Kurt Smits, Béatrice Vayssière, Thierry Christophe, Reginald Brys, L. Lepescheux, Ellen van der Aar, Luc Nelles, Fabrice Ciesielski, Guy Van Lommen, Pierre Deprez, Luc Juliaan Corina Van Rompaey, Muriel Uhring, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Philippe Clément-Lacroix, Javier Blanc, Nolwenn Jouannigot
Publikováno v:
Journal of Medicinal Chemistry. 57:9323-9342
Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small molecule has been shown to provide therapeutic immunomodulation. Having ident
Autor:
Kristof T. J. Loones, Anh Tho Nguyen, Johan Wouters, Evelyne M. Quinton, Oscar Mammoliti, Guy Van Lommen
Publikováno v:
Tetrahedron. 69(5):1669-1680
Two new single-step reactions allowing the construction of two heterocyclic motifs are reported. Both processes involve 5-substituted 1,3,4-thiadiazol-2- amines as starting materials. Reaction with 1-fluoro-2-nitrobenzenes in presence of Hünig's bas
Autor:
Mieke Buntinx, Jean Pierre Frans Van Wauwe, Erwin Coesemans, Jean-Pierre André Marc Bongartz, Guy Van Lommen, Bart Hermans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5819-5823
The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-cholinergic activity and identificatio
Autor:
Jean Pierre Frans Van Wauwe, Staf Boeckx, Julien Doyon, Mieke Buntinx, Bart Hermans, J. Goossens, Ron A. H. J. Gilissen, Guy Van Lommen, Erwin Coesemans, Dieder Moechars
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:1-9
The interaction between CC chemokine receptor 2 (CCR2) with monocyte chemoattractant proteins, such as MCP-1, regulates the activation and recruitment of inflammatory leukocytes. In this study, we characterized ( S )-3-[3,4-difluoro-phenyl)-propyl]-5
Autor:
Yong Gong, Guy Van Lommen, Jian Li, Concha Claes, Wei He, Pamela J. Hornby, Mieke Buntinx, J. Kent Barbay, Jean Pierre Frans Van Wauwe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3852-3855
A series of aniline-substituted tetrahydroquinoline C5a receptor antagonists were discovered. A functionality requirement of ortho substitution on the aniline was revealed. Secondary anilines, in general, outperformed tertiary analogs in inhibition o
Autor:
Wei He, Yong Gong, Guy Van Lommen, Jean Pierre Frans Van Wauwe, J. Kent Barbay, Concha Claes, Pamela J. Hornby, Mieke Buntinx, Jian Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2544-2548
A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determin
Publikováno v:
ChemInform. 46
Ring-closing metathesis of dienes (I) in the presence of Umicor M2 catalyst followed by reaction with hydrazine hydrate provides pyrazolone fused tetrahydroazepinones (III).
Publikováno v:
ChemInform. 46
The presented organophosphorus-catalyzed diaza-Wittig reaction affords substituted pyridazine derivatives bearing electron-withdrawing groups with good to excellent yields.
Autor:
Alex De Groot, Patrick Bultinck, Tom Kuppens, David Corens, Guy Van Lommen, Wouter A. Herrebout, Julien Doyon, Benjamin J. van der Veken
Publikováno v:
Chirality: the pharmaceutical, biological, and chemical consequences of molecular asymmetry
The absolute configurations of two precursors, that is, 1-(3′,4′-dichlorophenyl)-propanol and 1-(3′,4′-dichlorophenyl)-propanamine, of a potent 2-mercapto-imidazoleCCR-2 receptor antagonist, JNJ-27553292, were determined using vibrational cir