Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Guy Sevigny"'
Autor:
Jonathan M. Schapiro, Jocelyn Yelle, Jinzi J. Wu, Serge Dandache, Guy Sevigny, Mark A. Wainberg, Brent Richard Stranix, Neil Parkin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:4036-4043
At the end of 2005, an estimated 38.6 million people worldwide were living with human immunodeficiency virus (HIV), with approximately 4.1 million cases of new infections and 2.8 million deaths due to AIDS (32). Highly active antiretroviral therapy (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b31f2017c2f07824b79a959fba01ee2
https://doi.org/10.1128/aac.00149-07
https://doi.org/10.1128/aac.00149-07
Autor:
Guy Sevigny, Valérie Perron, Nicholas LeBerre, Dominik Herbart, Jinzi J. Wu, Jean-François Lavallée, Jocelyn Yelle, Brent Richard Stranix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3459-3462
A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8b05dd2203e20c7342e673032d2e1d
https://doi.org/10.1016/j.bmcl.2006.04.011
https://doi.org/10.1016/j.bmcl.2006.04.011
Autor:
Brent Richard Stranix, Jean-François Lavallée, Jinzi J. Wu, Jocelyn Yelle, Nicholas LeBerre, Guy Sevigny, Valérie Perron, Dominik Herbart
Publikováno v:
ChemInform. 37
A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f86f3105b8f1d5317868ab83b63623
https://doi.org/10.1002/chin.200639210
https://doi.org/10.1002/chin.200639210
Autor:
Alexandre Côté, Gilles Sauve, Abderrahim Bouzide, Jocelyn Yelle, Brent Richard Stranix, Guy Sevigny
Publikováno v:
ChemInform. 35
A series of N α-isobutyl- N α-arylsulfonamido-( N e acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nα -(arylsulfonamide)- Nα -iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db01f97bee4ea0bb722c9bd9eb17a9bb
https://doi.org/10.1002/chin.200414202
https://doi.org/10.1002/chin.200414202
Autor:
Jocelyn Yelle, Guy Sevigny, Valérie Perron, Gilles Sauve, Abderrahim Bouzide, Brent Richard Stranix, Alexandre Côté
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(15)
A series of lysine sulfonamide analogues bearing a Nepsilon-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nalpha-(alkyl)-Nalpha-(sulfonamides)lysinol using alpha-amino-caprolactam was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8217009d9b9ca51e7740e62c7b59d699
https://pubmed.ncbi.nlm.nih.gov/15225709
https://pubmed.ncbi.nlm.nih.gov/15225709
Autor:
Abderrahim Bouzide, Brent Richard Stranix, Gilles Sauve, Alexandre Côté, Jocelyn Yelle, Guy Sevigny
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(24)
A series of Nalpha-isobutyl-Nalpha-arylsulfonamido-(Nepsilon acyl) lysine and lysinol derivatives were prepared and evaluated as inhibitors of HIV protease and wild type virus. A simple original synthesis was devised to form Nalpha-(arylsulfonamide)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a463bd810bdf9cf8a8db3517cc00d592
https://pubmed.ncbi.nlm.nih.gov/14643311
https://pubmed.ncbi.nlm.nih.gov/14643311
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(20)
The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5286a38cf13b7fb899f32d0efd9c43
https://pubmed.ncbi.nlm.nih.gov/14505679
https://pubmed.ncbi.nlm.nih.gov/14505679
Autor:
Claude A. Jakob, David Y. Thomas, Guy Sevigny, Marc F. Pelletier, Eric Chevet, Daniel C. Tessier, Robert Ménard, John J.M. Bergeron, Anne Marcil
Publikováno v:
Glycobiology. 10(8)
Glucosidase II is an ER heterodimeric enzyme that cleaves sequentially the two innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on nascent glycoproteins. This processing allows the binding and release of monoglucosylated (Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab2645d43819994d2f0d22f37bb2df3
https://pubmed.ncbi.nlm.nih.gov/10929008
https://pubmed.ncbi.nlm.nih.gov/10929008