Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Guy Servant"'
Autor:
Guy Servant, Terry Kenakin
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107211- (2024)
Several non-caloric sweeteners exhibit a delay in sweetness onset and a sweetness linger after sampling. These temporal properties are thought to be the result of non-specific interactions with cell membranes and proteins in the oral cavity. Data and
Externí odkaz:
https://doaj.org/article/be733412eb8f460686f5ca8b90b20f0b
Autor:
Nicole B. Servant, Mark E. Williams, Paul F. Brust, Huixian Tang, Melissa S. Wong, Qing Chen, Marketa Lebl-Rinnova, Sara L. Adamski-Werner, Catherine Tachdjian, Guy Servant
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude. Yet, it is not clear if
Externí odkaz:
https://doaj.org/article/9d914c5347d74a30adf157b87bbb8adf
Autor:
Donald S. Karanewsky, Guy Servant, Hanghui Liu, Bert Chi, Lily Ida, Michael Saganich, Sara Werner, Joseph R. Fotsing, Andrew Patron, Catherine Tachdjian, Amy Arthur
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 507-520 (2017)
A toxicological evaluation of N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218; CAS 1622458-34-7), a flavour with modifying properties, was completed for the purpose of assessin
Externí odkaz:
https://doaj.org/article/e104bf811a6b41778b1fd0b467f96e72
Autor:
Guy, Servant, Eric, Frerot
Publikováno v:
Handbook of experimental pharmacology. 275
Umami, the fifth taste, has been recognized as a legitimate taste modality only recently relative to the other tastes. Dozens of compounds from vastly different chemical classes elicit a savory (also called umami) taste. The prototypical umami substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a5c9f6d7fe172a85effeff3942e2aab
https://pubmed.ncbi.nlm.nih.gov/33580387
https://pubmed.ncbi.nlm.nih.gov/33580387
Autor:
Eric Frerot, Guy Servant
Publikováno v:
The Pharmacology of Taste ISBN: 9783031064494
Umami, the fifth taste, has been recognized as a legitimate taste modality only recently relative to the other tastes. Dozens of compounds from vastly different chemical classes elicit a savory (also called umami) taste. The prototypical umami substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02c1407734b15ccb30deb1213f0fca3
https://doi.org/10.1007/164_2021_439
https://doi.org/10.1007/164_2021_439
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 88
Humans perceive sweet taste via activation of a specific taste receptor expressed at the surface of taste receptor cells located on the tongue and soft palate papillae. The sweet taste receptor functions as an obligate heterodimer, comprising two dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c687e823aafc1e2914b888ca0a453999
https://pubmed.ncbi.nlm.nih.gov/32416872
https://pubmed.ncbi.nlm.nih.gov/32416872
Autor:
Lan Zhang, Hanghui Liu, Brett Weylan Ching, Guy Servant, Tanya Ditschun, Andrew Patron, Thomas Brady, Mark C. Williams, Melissa Arellano, Vincent Darmohusodo, Michael Saganich, Qing Chen, Timothy Davis, Catherine Tachdjian, Donald S. Karanewsky, Joseph R. Fotsing
Publikováno v:
Journal of medicinal chemistry. 63(9)
In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blocker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bf37e3c7509316160de3e35812932e
https://pubmed.ncbi.nlm.nih.gov/32330040
https://pubmed.ncbi.nlm.nih.gov/32330040
Humans perceive sweet taste via activation of a specific taste receptor expressed at the surface of taste receptor cells located on the tongue and soft palate papillae. The sweet taste receptor functions as an obligate heterodimer, comprising two dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f33824d4e571707b9d68f9ba79a1ac
https://doi.org/10.1016/bs.apha.2020.01.002
https://doi.org/10.1016/bs.apha.2020.01.002
Autor:
R. Kyle Palmer, Guy Servant
The Pharmacology of Taste is comprised of contributions by leading scientists from the field of chemosensory research, presented all together in the context of pharmacological principles of receptor function. The chapters cover all levels of scientif
Autor:
Faber Nathan, Alain Noncovich, Guy Servant, Nicole Gonsalves, Paul Brust, Tanya Ditschun, Jane Ung, Andrew Patron, Hanghui Liu, Nicole Servant, Chad Priest
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3931-3938
The paper presents the activity trends for a novel series of phenoxyacetyl amides as human TRPM8 receptor agonists. This series encompasses in vitro activity values ranging from the micromolar to the picomolar levels. Sensory evaluation of these mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b055d78c3adc8356a22f49b490adfa
https://doi.org/10.1016/j.bmcl.2017.04.003
https://doi.org/10.1016/j.bmcl.2017.04.003