Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Guy Sella"'
Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence
Publikováno v:
eLife, Vol 12 (2023)
In many species, meiotic recombination events tend to occur in narrow intervals of the genome, known as hotspots. In humans and mice, double strand break (DSB) hotspot locations are determined by the DNA-binding specificity of the zinc finger array o
Externí odkaz:
https://doaj.org/article/c285cf48dbce43f3a2da569a3206e833
Publikováno v:
eLife, Vol 12 (2022)
Analyses of genetic variation in many taxa have established that neutral genetic diversity is shaped by natural selection at linked sites. Whether the mode of selection is primarily the fixation of strongly beneficial alleles (selective sweeps) or pu
Externí odkaz:
https://doaj.org/article/d193c09a5f3f45d9b1ed9107cd2113c5
Autor:
Laura Katharine Hayward, Guy Sella
Publikováno v:
eLife, Vol 11 (2022)
Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood. Here, we model this process analytically, in the plausible setting of a highly polygenic, quantitative trait that experiences a sudden shift in the fitness optimum. We s
Externí odkaz:
https://doaj.org/article/bce3619afc144a7e989cf4206b50b074
Autor:
William R. Milligan, Zachary L. Fuller, Ipsita Agarwal, Michael B. Eisen, Molly Przeworski, Guy Sella
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
New emerging infectious diseases are identified every year, a subset of which become global pandemics like COVID-19. In the case of COVID-19, many governments have responded to the ongoing pandemic by imposing social policies that restrict contacts o
Externí odkaz:
https://doaj.org/article/c4a0c894731e4679b10ac75576e4e4f4
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2002985 (2018)
Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of variants that contribute to heritable variation in a trait. To interpret these fi
Externí odkaz:
https://doaj.org/article/5d63b90bf6e4402c94cdd11d404ea3ad
Autor:
Eyal Elyashiv, Shmuel Sattath, Tina T Hu, Alon Strutsovsky, Graham McVicker, Peter Andolfatto, Graham Coop, Guy Sella
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006130 (2016)
Natural selection at one site shapes patterns of genetic variation at linked sites. Quantifying the effects of "linked selection" on levels of genetic diversity is key to making reliable inference about demography, building a null model in scans for
Externí odkaz:
https://doaj.org/article/ecc2fc81baf54492ab6158e616dbf866
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002355 (2016)
Mutations can originate from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that arise between replication cycles and are not repaired correctly. We introduce a model that relates the source of mutations to thei
Externí odkaz:
https://doaj.org/article/e1b50a9496224d259e1be4c1d90bd72d
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001302 (2011)
In Drosophila, multiple lines of evidence converge in suggesting that beneficial substitutions to the genome may be common. All suffer from confounding factors, however, such that the interpretation of the evidence-in particular, conclusions about th
Externí odkaz:
https://doaj.org/article/12adb68229da4e62ace5b2f77485aa69
Publikováno v:
PLoS Genetics, Vol 5, Iss 6, p e1000495 (2009)
Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the functionally constrained fraction of the genome is relatively small and that adaptation is
Externí odkaz:
https://doaj.org/article/247299c5eba64aa1a9b7162ffc3bf237
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000336 (2009)
Much effort and interest have focused on assessing the importance of natural selection, particularly positive natural selection, in shaping the human genome. Although scans for positive selection have identified candidate loci that may be associated
Externí odkaz:
https://doaj.org/article/1c223b49e45249808a0efc90fae6e706