Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Guy S. Salvesen"'
Autor:
Maria I. Avrutsky, Claire W. Chen, Jacqueline M. Lawson, Scott J. Snipas, Guy S. Salvesen, Carol M. Troy
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
PurposeRetinal vein occlusion (RVO) is a sight-threatening condition typically treated with intravitreal injection of vascular endothelial growth factor (VEGF) antagonists. Treatment response to anti-VEGF therapies is highly variable, with poor visua
Externí odkaz:
https://doaj.org/article/343ce8dd0fbf4bde92bc9cbfe8a8de51
Autor:
Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Retinal vein occlusion can cause blindness, and features neuronal dysfunction, inflammation and breakdown of vascular integrity. Here the authors report a non-apoptotic role of endothelial caspase-9 in regulating blood-retina barrier integrity and ne
Externí odkaz:
https://doaj.org/article/4688da8d4e524bccb33f889dc5ad0823
Autor:
Thomas S. Corrigan, Leilani M. Lotti Diaz, Sarah E. Border, Steven C. Ratigan, Kayla Q. Kasper, Daniel Sojka, Pavla Fajtova, Conor R. Caffrey, Guy S. Salvesen, Craig A. McElroy, Christopher M. Hadad, Özlem Doğan Ekici
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1387-1402 (2020)
Aza-peptide aldehydes and ketones are a new class of reversible protease inhibitors that are specific for the proteasome and clan CD cysteine proteases. We designed and synthesised aza-Leu derivatives that were specific for the chymotrypsin-like acti
Externí odkaz:
https://doaj.org/article/31bf5971d3b54bc09b1c70a575cfb101
Autor:
Zsofi Digby, Panagiotis Tourlomousis, James Rooney, Joseph P. Boyle, Betsaida Bibo-Verdugo, Robert J. Pickering, Steven J. Webster, Thomas P. Monie, Lee J. Hopkins, Nobuhiko Kayagaki, Guy S. Salvesen, Soren Warming, Lucy Weinert, Clare E. Bryant
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109614- (2021)
Summary: Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. The Carnivora, like mink, carry many zoonoses, yet how diversity in host immune genes across species affect pathogen carriage is poorly und
Externí odkaz:
https://doaj.org/article/bb9d22033809476d95fc1b138b38dc56
Autor:
Sabrina Sofia Burgener, Nathan Georges François Leborgne, Scott J. Snipas, Guy S. Salvesen, Phillip Ian Bird, Charaf Benarafa
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3646-3656.e5 (2019)
Summary: Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors. Here, we show that the in
Externí odkaz:
https://doaj.org/article/02b444e9617f49b48ada14e98ee20cfc
Autor:
Maria I. Avrutsky, Crystal Colón Ortiz, Kendra V. Johnson, Anna M. Potenski, Claire W. Chen, Jacqueline M. Lawson, Alexandra J. White, Stephanie K. Yuen, Fatima N. Morales, Elisa Canepa, Scott Snipas, Guy S. Salvesen, Ying Y. Jean, Carol M. Troy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/3967406557774ccfbdefb75fc3e62a7e
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52d1d09ef5675e7f5147104a20729cce
https://doi.org/10.1016/b978-0-12-821618-7.00280-7
https://doi.org/10.1016/b978-0-12-821618-7.00280-7
Publikováno v:
Biochemical Journal. 478:2233-2245
Caspases are a family of enzymes that play roles in cell death and inflammation. It has been suggested that in the execution phase of the apoptotic pathway, caspase-3, -6 and -7 are involved. The substrate specificities of two proteases (caspases 3 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f564e7114f0d4a171ea8851a9d6cdf44
https://doi.org/10.1042/bcj20210255
https://doi.org/10.1042/bcj20210255
Publikováno v:
Biochem J
A patient diagnosed with multiple myeloma, bicuspid aortic valve, and Von Hippel–Lindau syndrome underwent whole-exome sequencing seeking a unified genetic cause for these three pathologies. The patient possessed a single-point mutation of arginine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0382efe8ad0a4c24fa6a00a3ea0a0181
https://europepmc.org/articles/PMC10084813/
https://europepmc.org/articles/PMC10084813/
Autor:
Wioletta Rut, Marcin Poreba, Matej Vizovišek, Scott J. Snipas, Milind Pore, Guy S. Salvesen, Boris Turk, Katarzyna Groborz, Marcin Drag, Peter Kuhn
Publikováno v:
J Am Chem Soc
The subset of the proteome that contains enzymes in their catalytically active form can be interrogated by using probes targeted toward individual specific enzymes. A subset of such enzymes are proteases that are frequently studied with activity-base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0cff39ce0e5923250d8a38676155560
https://doi.org/10.1021/jacs.0c06762
https://doi.org/10.1021/jacs.0c06762