Výsledky vyhledávání - "Guy R. Watkins"

Akademický článek

Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster.

Autor: Ning Wang, Hung-Tat Leung, Matthew D Mazalouskas, Guy R Watkins, Rey J Gomez, Brian E Wadzinski

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38569 (2012)

Protein ser/thr phosphatase 2A family members (PP2A, PP4, and PP6) are implicated in the control of numerous biological processes, but our understanding of the in vivo function and regulation of these enzymes is limited. In this study, we investigate

Externí odkaz: https://doaj.org/article/24fa30f024424bde8b4f200fa244e315

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Alpha4 Is a Ubiquitin-Binding Protein That Regulates Protein Serine/Threonine Phosphatase 2A Ubiquitination

Autor: Jamie L. McConnell, Benjamin W. Spiller, Sarah E. Soss, Walter J. Chazin, Lisa R. McCorvey, Brian E. Wadzinski, Heidi S. Franz, Guy R. Watkins

Publikováno v: Biochemistry. 49:1713-1718

Multiple regulatory mechanisms control the activity of the protein serine/threonine phosphatase 2A catalytic subunit (PP2Ac), including post-translational modifications and its association with regulatory subunits and interacting proteins. Alpha4 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d743dcc851a1f5ea017a1a7224944a1
https://doi.org/10.1021/bi901837h

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Structural basis of protein phosphatase 2A stable latency

Autor: Yongna Xing, Kenneth A. Satyshur, Vitali Stanevich, Li Jiang, Rituparna Sengupta, Mei Kong, Brian E. Wadzinski, Guy R. Watkins

Publikováno v: Nature Communications

The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report the structure of α4 bound to the N-terminal fragment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e43cbfdca26f2e5f9e9e43c152f838b
https://pubmed.ncbi.nlm.nih.gov/23591866

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Essential roles of the Tap42-regulated protein phosphatase 2A (PP2A) family in wing imaginal disc development of Drosophila melanogaster

Autor: Hung-Tat Leung, Ning Wang, Guy R. Watkins, Matthew D. Mazalouskas, Rey J. Gomez, Brian E. Wadzinski

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38569 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350b0e74bb0399a4b65633c421dc021e
http://europepmc.org/articles/PMC3368869?pdf=render

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The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation

Autor: Katherine L. Germane, Brian E. Wadzinski, Benjamin W. Spiller, Ping Zou, Guy R. Watkins, Michele LeNoue-Newton, Lisa R. McCorvey

Publikováno v: The Journal of biological chemistry. 286(20)

Protein phosphatase 2A (PP2A) is regulated through a variety of mechanisms, including post-translational modifications and association with regulatory proteins. Alpha4 is one such regulatory protein that binds the PP2A catalytic subunit (PP2Ac) and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a348002e490e7a2b3a29bb87ca44d5
https://pubmed.ncbi.nlm.nih.gov/21454489

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Bacillus cereus Phosphopentomutase Is an Alkaline Phosphatase Family Member That Exhibits an Altered Entry Point into the Catalytic Cycle*

Autor: T.D. Panosian, Brian O. Bachmann, Brian E. Wadzinski, W. Hayes McDonald, Tina M. Iverson, Vanessa V. Phelan, Guy R. Watkins, D.P. Nannemann

Bacterial phosphopentomutases (PPMs) are alkaline phosphatase superfamily members that interconvert α-D-ribose 5-phosphate (ribose 5-phosphate) and α-D-ribose 1-phosphate (ribose 1-phosphate). We investigated the reaction mechanism of Bacillus cere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d762cfe14a7548263d481596468dcb1
https://europepmc.org/articles/PMC3048691/

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Akademický článek

A Novel Experimental Bilateral Blunt Chest Trauma Model on Rabbits and its Effects in Lung.

Autor: Kaya, Halil¹ drhalilkaya@gmail.com, Kafalı, Mehmet Ertuğrul², Aydın, Kemal³, Şahin, Mustafa², Duran, Arif⁴, Bayır, Ayşegül⁵, Toy, Hatice⁶, Söğüt, Özgür¹

Publikováno v: Journal of Academic Emergency Medicine / Akademik Acil Tip Olgu Sunumlari Dergisi. Sep2011, Vol. 10 Issue 3, p103-109. 7p. 3 Color Photographs, 2 Charts, 6 Graphs.

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