Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Guy R. Simpson"'
Autor:
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure w
Externí odkaz:
https://doaj.org/article/de1a4f0585554636831662f1395174a1
Autor:
Nicola E. Annels, Guy R. Simpson, Mick Denyer, Mehreen Arif, Matt Coffey, Alan Melcher, Kevin Harrington, Richard Vile, Hardev Pandha
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 434-446 (2021)
Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells. This non-inflamed phenotype is likely responsible for the lack
Externí odkaz:
https://doaj.org/article/1fcecfe43cb14392b18d5ef88fd32378
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
It is now well-recognized that the tumor microenvironment (TME) is not only a key regulator of cancer progression but also plays a crucial role in cancer treatment responses. Recently, several high-profile publications have demonstrated the importanc
Externí odkaz:
https://doaj.org/article/72ac751f85a5478a8793fe0668cda45e
Autor:
Ayssar A. Elamin, Saskia Klunkelfuß, Susanne Kämpfer, Wulf Oehlmann, Matthias Stehr, Christopher Smith, Guy R. Simpson, Richard Morgan, Hardev Pandha, Mahavir Singh
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Urothelial carcinoma of the urinary bladder (UCB) or bladder cancer remains a major health problem with high morbidity and mortality rates, especially in the western world. UCB is also associated with the highest cost per patient. In recent years num
Externí odkaz:
https://doaj.org/article/07502e8b8bee4f2f8cea7adcedc064f1
Autor:
Nicola E. Annels, Mehreen Arif, Guy R. Simpson, Mick Denyer, Carla Moller-Levet, David Mansfield, Rachel Butler, Darren Shafren, Gough Au, Margaret Knowles, Kevin Harrington, Richard Vile, Alan Melcher, Hardev Pandha
Publikováno v:
Molecular Therapy: Oncolytics, Vol 9, Iss , Pp 1-12 (2018)
As a clinical setting in which local live biological therapy is already well established, non-muscle invasive bladder cancer (NMIBC) presents intriguing opportunities for oncolytic virotherapy. Coxsackievirus A21 (CVA21) is a novel intercellular adhe
Externí odkaz:
https://doaj.org/article/547e325fd60c43019bb01a1537f873cb
Autor:
Hardev S. Pandha, Darren Shafren, Hugh Mostafid, Richard Vile, Bernard Fox, Izhar Bagwan, Mark Grose, Gough Au, Bronwyn Davies, Kevin J. Harrington, Alan A. Melcher, Sarbjinder S. Sandhu, Mick Denyer, Guy R. Simpson, Carmen Ballesteros-Merino, Mehreen Arif, David Mansfield, Nicola E. Annels
Purpose:The CANON [CAVATAK in NON–muscle-invasive bladder cancer (NMIBC)] study evaluated a novel ICAM-1–targeted immunotherapeutic-coxsackievirus A21 as a novel oncolytic agent against bladder cancer.Patients and Methods:Fifteen patients enrolle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c04dacdae8e77cecf4dc1f2852a60b
https://doi.org/10.1158/1078-0432.c.6528416.v1
https://doi.org/10.1158/1078-0432.c.6528416.v1
Autor:
Hardev S. Pandha, Darren Shafren, Hugh Mostafid, Richard Vile, Bernard Fox, Izhar Bagwan, Mark Grose, Gough Au, Bronwyn Davies, Kevin J. Harrington, Alan A. Melcher, Sarbjinder S. Sandhu, Mick Denyer, Guy R. Simpson, Carmen Ballesteros-Merino, Mehreen Arif, David Mansfield, Nicola E. Annels
Supplementary data - revised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cee480ac1ee5f0a60ca406c3be2c3bc
https://doi.org/10.1158/1078-0432.22473104
https://doi.org/10.1158/1078-0432.22473104
Autor:
Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan, Hardev Pandha
Publikováno v:
BMC Cancer
Background Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has
Autor:
Jennifer E. Adair, Jahangir Ahmed, Ghassan Alusi, Doron Amit, Scott J. Antonia, Dominick L. Auci, David A. August, Rutger K. Balvers, Lajos Baranyi, Brian C. Beard, Sebastian Brennig, Elizabeth K. Broussard, Paul D. Bryson, Andrew P. Byrnes, Denise L. Cecil, Tim Chan, Charlie Comins, Christiaan R. de Vries, Robert S. DiPaola, Clemens M.F. Dirven, Mary L. Disis, Boro Dropulic, Heather Embree, Michael W. Epperly, Juan Fueyo, Toshiyoshi Fujiwara, Hua Fung, Emmanuel Gabriel, Vidya Ganapath, Stanton L. Gerson, Steven Gill, Michal Gilon, Joe Goldufsky, Candelaria Gomez-Manzano, Jennifer Rubin Grandis, Joel S. Greenberger, John W. Greiner, Maneesh Gujrati, James L. Gulley, Amin Hajitou, Kevin J. Harrington, Arash Hatefi, Loree C. Heller, Richard Heller, Akseli Hemminki, Otto Hemminki, Ronald B. Herberman, Daniel Herendeen, Abraham Hochberg, James W. Hodge, Gregory E. Holt, Ying Huang, Insoo Hyun, Hong Jiang, Shunsuke Kagawa, Zahra Karjoo, Howard Kaufman, Chien-Chih Ke, Hans-Peter Kiem, Jonathan Kimmelman, Sarah R. Klein, Shinji Kuroda, Seong Young Kwon, Nico Lachmann, Hermann Lage, Martine L.M. Lamfers, Edmund C. Lattime, Nicholas R. Lemoine, Jonathan Lewis, John B. Liao, Steven K. Libutti, Yuan Lin, Ren-Shyan Liu, Zheng-Rong Lu, Ravi A. Madan, Imad Matouk, Alan Melcher, Andrew D. Miller, Jung-Joon Min, Thomas Moritz, James J. Mulé, Atsushi Natsume, Nastasia Nianiaris, Michael I. Nishimura, Claudia Palena, Hardev Pandha, Jessica Pastoriza, Mary C. Pinder-Schenck, Sujan Piya, Elizabeth Poplin, John A. Puskas, Thomas Quinn, Ankit Rao, Jane S. Reese, Kate Relph, Juan J. Rojas, Yvonne Saenger, Jeffrey Schlom, Kevin Shannon, Shawna A. Shirley, Guy R. Simpson, Shanthi Sivendran, Vladimir Slepushkin, Sirirurg Songsivilai, Neil Steven, Sufi Mary Thomas, Steve H. Thorne, Kwong-Yok Tsang, Takashi Tsujiuchi, Toshihiko Wakabayashi, Pin Wang, Xinxin Wang, Yaohe Wang, Robert E. Weiss, Edward White, Yohsuke Yagawa, Teerapong Yata, Ming Yuan, Ziqiang Yuan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9859ecd7a8906dc1395cd68c9b25af0d
https://doi.org/10.1016/b978-0-12-394295-1.00046-9
https://doi.org/10.1016/b978-0-12-394295-1.00046-9
Autor:
Guy R, Simpson, Robert S, Coffin
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 542
A large number of oncolytic viral vectors are currently under clinical development for cancer therapy. Herpes simplex virus type 1 (HSV-1) has demonstrated particular promise in this field, showing genetically engineered selective tumor replication a