Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Guy R. Humphrey"'
Autor:
Matthew S. Winston, Marc Poirier, Zhijian Liu, Feng Peng, Guy R. Humphrey, John A. McIntosh, Mikhail Reibarkh, Fengqiang Wang, Erik D. Guetschow, Steve Castro, Erik Hoyt, David J. Lamberto, Kevin Sirk
Publikováno v:
Organic Process Research & Development. 27:179-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc86545e85638ae22f318904489ad7f
https://doi.org/10.1021/acs.oprd.2c00327
https://doi.org/10.1021/acs.oprd.2c00327
Autor:
Birgit Kosjek, Rishi G. Vaswani, Neil A. Strotman, Jun Pan, Chaoxian Cai, Rebecca T. Ruck, Guy R. Humphrey
Publikováno v:
Organic Process Research & Development. 26:648-656
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a2691bca6cc557c5dde52ad2cc5c66
https://doi.org/10.1021/acs.oprd.1c00128
https://doi.org/10.1021/acs.oprd.1c00128
Autor:
Anne E. Mohan, Siqing Song, Hsieh Yao D. Chang, Si-Wei Zhang, Patrick Larpent, Wenjun Liu, Michael DiBenedetto, Eric B. Sirota, Michael J. Di Maso, Richard Desmond, Kevin M. Maloney, Ivan H. Lee, Alfred Y. Lee, Guy R. Humphrey, Embarek Alwedi, Hong Ren
Publikováno v:
Organic Process Research & Development. 24:2498-2504
The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment of chronic cough, is described. Due to ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd961a62dfed3fd28d482411a9320b
https://doi.org/10.1021/acs.oprd.0c00260
https://doi.org/10.1021/acs.oprd.0c00260
Autor:
Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Publikováno v:
Organic Process Research & Development. 24:2445-2452
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95c8b1da5db499a674207974d58e42c1
https://doi.org/10.1021/acs.oprd.0c00248
https://doi.org/10.1021/acs.oprd.0c00248
Autor:
Eric B. Sirota, Karthik Narsimhan, Feng Peng, Mark Weisel, Alfred Y. Lee, Rebecca A. Arvary, Claire Lee, Daniel Bishara, Kevin M. Maloney, Andrew Brunskill, François Lévesque, Patrick Larpent, Michael Whittington, John R. Naber, Guy R. Humphrey, Dan Lehnherr, Si-Wei Zhang
Publikováno v:
Organic Process Research & Development. 24:2453-2461
Various synthetic routes to 2-isopropyl-4-methoxyphenol 3, the phenol core of Gefapixant citrate (MK-7264), are described, which provide better alternatives to the initial four-step supply route. T...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1151aa0b8950e409e75134288d2f80
https://doi.org/10.1021/acs.oprd.0c00241
https://doi.org/10.1021/acs.oprd.0c00241
Autor:
Kevin R. Campos, Kevin M. Maloney, Li Zhang, Yong-Li Zhong, Daniel J. Muzzio, Guy R. Humphrey, Mark Weisel
Publikováno v:
Organic Process Research & Development. 24:1602-1608
Although diazeniumdiolates (DAZDs) and the synthetic methods to access DAZDs were discovered over 50 years ago, the current methodology is not safe, has a limited substrate scope, and is not amenab...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1752bde773bedc744de68fce6ff62e7b
https://doi.org/10.1021/acs.oprd.0c00067
https://doi.org/10.1021/acs.oprd.0c00067
Autor:
Zhixun Wang, Eric B. Sirota, Mark Weisel, John Y. L. Chung, Aaron M. Whittaker, Cyndi Qixin He, Donald R. Gauthier, François Lévesque, Danielle M. Schultz, Akasha K. Purohit, Yong-Li Zhong, Yingju Xu, Jonathan P. McMullen, Guy R. Humphrey, Varsolona Richard J, Cynthia M. Hong, Kevin M. Maloney
Publikováno v:
Organic Process Research & Development. 25:395-404
We report the practical synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb878695b7066d10e2d7723b11cd71a
https://doi.org/10.1021/acs.oprd.0c00304
https://doi.org/10.1021/acs.oprd.0c00304
Autor:
Peter E. Maligres, Tao Pei, Jinquin Yin, Zhiguo Jake Song, Guy R. Humphrey, Tetsuji Itoh, Hallena R. Strotman, Edward C. Sherer, Neil A. Strotman
Publikováno v:
Synthesis. 52:3378-3388
Controlling the absolute and relative stereochemistry of a seven-membered oxepane in the formation of HIV integrase inhibitor MK-1376 was accomplished through a strategy involving the use of asymmetric allylation and stereoconvergent, substrate-direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3318798142b6d1ff0a6f174b21f356c
https://doi.org/10.1055/s-0040-1707994
https://doi.org/10.1055/s-0040-1707994
Autor:
Peter E. Maligres, Jeff Fritzen, Guy R. Humphrey, Yonggang Chen, Zhiguo Jake Song, Jonathan E. Wilson, Carmela Molinaro
Publikováno v:
Organic Process Research & Development. 23:2354-2361
2-(2H-Tetrazol-2-yl)benzoic acid 1 and analogs were prepared via Cu(I) catalyzed C–N coupling of 2-iodo or 2-bromo benzoic acids with 5-(ethylthio)-1H-tetrazole followed by reductive cleavage of the thioether bond. The C–N coupling was regioselec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea4b330d980b4a2134599072e151bae
https://doi.org/10.1021/acs.oprd.9b00243
https://doi.org/10.1021/acs.oprd.9b00243
Autor:
Helen F. Sneddon, Frank Roschangar, Sudhir Nambiar, Seth D. Ribe, Jeremy P. Scott, Michael E. Kopach, Scott V. Plummer, Guy R. Humphrey, Juan Colberg, Alina Borovika, Christiana Briddell, Isamir Martinez, Cisco Bee, Stefan G. Koenig
Publikováno v:
ACS Sustainable Chemistry & Engineering. 7:16937-16951
In an effort to improve sustainability and reduce the cost of goods for active pharmaceutical ingredients (APIs), pharma companies have partnered on varying portions of their supply chain with cont...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84afb2c0f74a6c1b1faa69c220f1e00b
https://doi.org/10.1021/acssuschemeng.9b02842
https://doi.org/10.1021/acssuschemeng.9b02842