Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Guy P. Mannaerts"'
Autor:
Veerle Foulon, Stanny Asselberghs, Wendy Geens, Guy P. Mannaerts, Minne Casteels, Paul P. Van Veldhoven
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 12, Pp 2349-2355 (2003)
Refsum disease is a peroxisomal disorder characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues. Approximately 45% of cases are caused by mutations in phytano
Externí odkaz:
https://doaj.org/article/af54776f16d6429fab29b86070138191
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1752-1759 (2000)
2-Methylacyl-CoA racemase is an auxiliary enzyme required for the peroxisomal β-oxidative breakdown of (2R)-pristanic acid and the (25R)-isomer of C27 bile acid intermediates. The enzyme activity is found not only in peroxisomes but also is present
Externí odkaz:
https://doaj.org/article/3bbee4f61fcb4ef9999cdc3438e405f8
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 4, Pp 629-636 (2000)
Phytanoyl-CoA hydroxylase is a peroxisomal α-oxidation enzyme that catalyzes the 2-hydroxylation of 3-methyl-branched acyl-CoAs. A polyhistidine-tagged human phytanoyl-CoA hydroxylase was expressed in E. coli and subsequently purified as an active p
Externí odkaz:
https://doaj.org/article/d14d9501d43a4a058b7a34ee084b7bff
Autor:
Kathleen Croes, Minne Casteels, Martine Dieuaide-Noubhani, Guy P. Mannaerts, Paul P. Van Veldhoven
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 4, Pp 601-609 (1999)
The stereochemistry of the α-oxidation of 3-methyl-branched fatty acids was studied in rat liver. R- and S-3-methylhexadecanoic acid were equally well α-oxidized in intact hepatocytes and homogenates. Subcellular fractionation studies showed that
Externí odkaz:
https://doaj.org/article/699d88aee25544a2b568bada5e043649
Autor:
Guy P. Mannaerts, Marc Fransen, Georgyi V. Los, Chantal Brees, Sofie Huybrechts, Paul P. Van Veldhoven
Publikováno v:
Traffic. 10:1722-1733
Despite the identification and characterization of various proteins that are essential for peroxisome biogenesis, the origin and the turnover of peroxisomes are still unresolved critical issues. In this study, we used the HaloTag technology as a new
Autor:
Paul P. Van Veldhoven, Anja Rabijns, Andreas Hartig, Guy P. Mannaerts, Marc Fransen, Chantal Brees, Leen Amery
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:864-873
Tetratricopeptide (TPR)-domain proteins are involved in various cellular processes. The TPR domain is known to be responsible for interaction with other proteins commonly recognizing sequence motifs at the C-termini. One such TPR-protein, TRIP8b, was
Autor:
Guy P. Mannaerts, Veerle Foulon, Mieke Sniekers, Stanny Asselberghs, Minne Casteels, Els Huysmans, Paul P. Van Veldhoven, Vincent Mahieu
Publikováno v:
Journal of Biological Chemistry. 280:9802-9812
2-Hydroxyfatty acids, constituents of brain cerebrosides and sulfatides, were previously reported to be degraded by an α-oxidation system, generating fatty acids shortened by one carbon atom. In the current study we used labeled and unlabeled 2-hydr
Autor:
Guy P. Mannaerts, Veerle Foulon, Wendy Geens, Minne Casteels, Paul P. Van Veldhoven, Stanny Asselberghs
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 12, Pp 2349-2355 (2003)
Refsum disease is a peroxisomal disorder characterized by adult-onset retinitis pigmentosa, anosmia, sensory neuropathy, ataxia, and an accumulation of phytanic acid in plasma and tissues. Approximately 45% of cases are caused by mutations in phytano
Publikováno v:
European Journal of Biochemistry. 270:1619-1627
3-Methyl-branched fatty acids, as phytanic acid, undergo peroxisomal alpha-oxidation in which they are shortened by 1 carbon atom. This process includes four steps: activation, 2-hydroxylation, thiamine pyrophosphate dependent cleavage and aldehyde d
Publikováno v:
Biochemical Journal. 365:41-50
Pex7p is a WD40-containing protein involved in peroxisomal import of proteins containing an N-terminal peroxisome-targeting signal (PTS2). The interaction of human recombinant Pex7p expressed in different hosts/systems with its PTS2 ligand and other