Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Guy Makin"'
Autor:
Nicola Fenwick, Rebekah Weston, Keith Wheatley, Jodie Hodgson, Lynley Marshall, Martin Elliott, Guy Makin, Antony Ng, Bernadette Brennan, Stephen Lowis, Jenny Adamski, John Paul Kilday, Rachel Cox, Mike Gattens, Andrew Moore, Toby Trahair, Milind Ronghe, Martin Campbell, Helen Campbell, Molly W. Williams, Maria Kirby, Natasha Van Eijkelenburg, Jennifer Keely, Ugo Scarpa, Victoria Stavrou, Livingstone Fultang, Sarah Booth, Paul Cheng, Carmela De Santo, Francis Mussai
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the pathophysiology of a number of pediatric cancers. We report the first in child study of
Externí odkaz:
https://doaj.org/article/4902b15b11094343be86c12a848d2cb8
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65304 (2013)
Survival rates from childhood cancer have improved dramatically in the last 40 years, such that over 80% of children are now cured. However in certain subgroups, including metastatic osteosarcoma, survival has remained stubbornly poor, despite dose i
Externí odkaz:
https://doaj.org/article/8867536a38ff498e9d136b6482dfd8b3
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48024 (2012)
Most investigations into cancer cell drug response are performed with cells cultured on flat (2D) tissue culture plastic. Emerging research has shown that the presence of a three-dimensional (3D) extracellular matrix (ECM) is critical for normal cell
Externí odkaz:
https://doaj.org/article/09bf3cb6bbea4dd98e59b4d458ef3fd7
Autor:
Birgit Geoerger, Lynley V. Marshall, Karsten Nysom, Guy Makin, Eric Bouffet, Anne-Sophie Defachelles, Loredana Amoroso, Isabelle Aerts, Pierre Leblond, Paulette Barahona, Kim Van-Vlerken, Eric Fu, Flavio Solca, Robert M. Lorence, David S. Ziegler
Publikováno v:
Geoerger, B, Marshall, L V, Nysom, K, Makin, G, Bouffet, E, Defachelles, A, Amoroso, L, Aerts, I, Leblond, P, Barahona, P, Van-Vlerken, K, Fu, E, Solca, F, Lorence, R M & Ziegler, D S 2023, ' Afatinib in paediatric patients with recurrent/refractory ErbB-dysregulated tumours: Results of a phase I/expansion trial ', European Journal of Cancer, vol. 188, pp. 8-19 . https://doi.org/10.1016/j.ejca.2023.04.007
AimThis phase I/expansion study assessed the safety, pharmacokinetics and preliminary antitumor activity of afatinib in paediatric patients with cancer.MethodsThe dose-finding part enroled patients (2–150); HER2 membrane staining (H-score>0). The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e7ec8128779224aaf622e0bc13f9e5
https://research.manchester.ac.uk/en/publications/dd144159-5cb1-4625-acc3-ccddb47135db
https://research.manchester.ac.uk/en/publications/dd144159-5cb1-4625-acc3-ccddb47135db
Neuroblastoma is a common solid tumor of childhood and advanced disease carries a poor prognosis despite intensive multimodality therapy. Hypoxia is a common feature of solid tumors because of poorly organized tumor-induced neovasculature. Hypoxia is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3646ca80384ac47ad90f4d56cc0083fc
https://doi.org/10.1158/1535-7163.c.6535294
https://doi.org/10.1158/1535-7163.c.6535294
Autor:
Darren Hargrave, Murray Yule, Melanie J. Griffin, Alan V. Boddy, John F. Lyons, Ana Rodriguez, Victoria Lock, Shamim Kazmi-Stokes, Philip Ross, Gary Acton, Sarah E.R. Halford, Guy Makin, Quentin Campbell-Hewson, Martin Elliott, Bruce Morland, Andrew D.J. Pearson, Lynley V. Marshall, Lucas Moreno
Supplementary Figure 1. Examples of changes observed in M30/M65 profiles as a function of dosing of AT9283 in two selected patients. Pt. 58/032 from cohort 4 (14.5 mg/m2/day) and Pt. 31/030 from cohort 6 (23 mg/m2/day).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecad42031facf935942fc7b688af840e
https://doi.org/10.1158/1078-0432.22460577.v1
https://doi.org/10.1158/1078-0432.22460577.v1
Autor:
Deborah A. Tweddle, David Jamieson, Nick Bown, Angharad Humphreys, Susan A. Burchill, Jennifer H. Wright, Michael L. Robinson, Alem S. Gabriel, Dermot Murphy, Antony Ng, Guy Makin, Mark Brougham, Hany Gabra, Elizabeth Gavens, Lindi Chen, Swathi Merugu
Purpose:Circulating tumor cells (CTCs) serve as noninvasive tumor biomarkers in many types of cancer. Our aim was to detect CTCs from patients with neuroblastoma for use as predictive and pharmacodynamic biomarkers.Experimental Design:We collected ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bfe1a6e674bc192c20eeffbdb6ca43
https://doi.org/10.1158/1078-0432.c.6528330.v1
https://doi.org/10.1158/1078-0432.c.6528330.v1
Autor:
Darren Hargrave, Murray Yule, Melanie J. Griffin, Alan V. Boddy, John F. Lyons, Ana Rodriguez, Victoria Lock, Shamim Kazmi-Stokes, Philip Ross, Gary Acton, Sarah E.R. Halford, Guy Makin, Quentin Campbell-Hewson, Martin Elliott, Bruce Morland, Andrew D.J. Pearson, Lynley V. Marshall, Lucas Moreno
Supplementary Table 1. Summary of pharmacodynamic changes observed in paired skin punch biopsies. Skin punch biopsies were optional until a dose limiting toxicity was found (11.5 mg/m2/day) when they were mandated. Inhibition of pHH3 (substrate for A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950e620f9c4ac0b51c81c065ed2a89b6
https://doi.org/10.1158/1078-0432.22460574
https://doi.org/10.1158/1078-0432.22460574
Autor:
Darren Hargrave, Murray Yule, Melanie J. Griffin, Alan V. Boddy, John F. Lyons, Ana Rodriguez, Victoria Lock, Shamim Kazmi-Stokes, Philip Ross, Gary Acton, Sarah E.R. Halford, Guy Makin, Quentin Campbell-Hewson, Martin Elliott, Bruce Morland, Andrew D.J. Pearson, Lynley V. Marshall, Lucas Moreno
Purpose: A phase I trial of AT9283 (a multitargeted inhibitor of Aurora kinases A and B) was conducted in children and adolescents with solid tumors, to identify maximum-tolerated dose (MTD), safety, efficacy, pharmacokinetics, and pharmacodynamic (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebdd8f39fe18202f828f43bd11730ed
https://doi.org/10.1158/1078-0432.c.6524535.v1
https://doi.org/10.1158/1078-0432.c.6524535.v1