Zobrazeno 1 - 10
of 749
pro vyhledávání: '"Guy M McKhann"'
Autor:
Elliot H Smith, Jyun-you Liou, Edward M Merricks, Tyler Davis, Kyle Thomson, Bradley Greger, Paul House, Ronald G Emerson, Robert Goodman, Guy M McKhann, Sameer Sheth, Catherine Schevon, John D Rolston
Publikováno v:
eLife, Vol 11 (2022)
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large intermittent electrophysiological events observed between seizures in patients with epilepsy. Although they occur far more often than seizures, IEDs are less studie
Externí odkaz:
https://doaj.org/article/f3cb8e2bbd074917bb1bd896a25eea72
Autor:
Jyun-you Liou, Elliot H Smith, Lisa M Bateman, Samuel L Bruce, Guy M McKhann, Robert R Goodman, Ronald G Emerson, Catherine A Schevon, LF Abbott
Publikováno v:
eLife, Vol 9 (2020)
We developed a neural network model that can account for major elements common to human focal seizures. These include the tonic-clonic transition, slow advance of clinical semiology and corresponding seizure territory expansion, widespread EEG synchr
Externí odkaz:
https://doaj.org/article/84839a980fe9444b9ad3de7774be2aeb
Autor:
Cheng-Hung Tai, Cheng-Chia Wu, Mark E Hwang, Anurag Saraf, Christopher Grubb, Ashish Jani, Matthew E Lapa, Jacquelyn I S Andrews, Steven R Isaacson, Adam M Sonabend, Sameer A Sheth, Guy M McKhann, Michael B Sisti, Jeffrey N Bruce, Simon K Cheng, Eileen P Connolly, Tony JC Wang
Publikováno v:
CNS Oncology, Vol 7, Iss 1, Pp 25-34 (2018)
Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & methods: We retrospectively gathered data from 127 breast cancer patients who u
Externí odkaz:
https://doaj.org/article/98760b8a48174ab3a28e68a83cbe0ea2
Autor:
Vishal Choudhari, Cong Han, Stephan Bickel, Ashesh D. Mehta, Catherine Schevon, Guy M. McKhann, Nima Mesgarani
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Focusing on a specific conversation amidst multiple interfering talkers is challenging, especially for those with hearing loss. Brain‐controlled assistive hearing devices aim to alleviate this problem by enhancing the attended speech based
Externí odkaz:
https://doaj.org/article/e5c1ff50e1754d53b2000b815cd2e740
Autor:
Anne L Baldock, Sunyoung Ahn, Russell Rockne, Sandra Johnston, Maxwell Neal, David Corwin, Kamala Clark-Swanson, Greg Sterin, Andrew D Trister, Hani Malone, Victoria Ebiana, Adam M Sonabend, Maciej Mrugala, Jason K Rockhill, Daniel L Silbergeld, Albert Lai, Timothy Cloughesy, Guy M McKhann, Jeffrey N Bruce, Robert C Rostomily, Peter Canoll, Kristin R Swanson
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e99057 (2014)
Malignant gliomas are incurable, primary brain neoplasms noted for their potential to extensively invade brain parenchyma. Current methods of clinical imaging do not elucidate the full extent of brain invasion, making it difficult to predict which, i
Externí odkaz:
https://doaj.org/article/0ced0b8a10164c7eab501eb0618de216
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54914 (2013)
Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the los
Externí odkaz:
https://doaj.org/article/7365613d8e5f4b62ad4b8c60a0e19d04
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Somin Lee, Sarita S. Deshpande, Edward M. Merricks, Emily Schlafly, Robert Goodman, Guy M. McKhann, Emad N. Eskandar, Joseph R. Madsen, Sydney S. Cash, Michel J. A. M. van Putten, Catherine A. Schevon, Wim van Drongelen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Spatiotemporal spike-centered averaging (st-SCA) allows for the visualization of spike-local field potential relationships across both temporal and spatial domains from microelectrode array recordings.
Externí odkaz:
https://doaj.org/article/f64613eac9844ef9ad9b9a070abe689d
Autor:
Alexander B. Herman, Elliot H. Smith, Catherine A. Schevon, Mark J. Yates, Guy M. McKhann, Matthew Botvinick, Benjamin Y. Hayden, Sameer A. Sheth
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108047- (2023)
Summary: The ability to perform motor actions depends, in part, on the brain’s initial state. We hypothesized that initial state dependence is a more general principle and applies to cognitive control. To test this idea, we examined human single un
Externí odkaz:
https://doaj.org/article/657564d27445475ebec4c18be0766d5e
Autor:
Osama Al-Dalahmah, Alexander A. Sosunov, Yu Sun, Yang Liu, Nacoya Madden, E. Sander Connolly, Carol M. Troy, Guy M. McKhann, James E. Goldman
Publikováno v:
Cells, Vol 13, Iss 2, p 129 (2024)
In the mammalian isocortex, CD44, a cell surface receptor for extracellular matrix molecules, is present in pial-based and fibrous astrocytes of white matter but not in protoplasmic astrocytes. In the hominid isocortex, CD44+ astrocytes comprise the
Externí odkaz:
https://doaj.org/article/ca845e2049f9456694582ee77233a2d0