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Autor:
Guy Müller Banquet Okra, Affiba Florance Kouassi, Dali Brice, Hermann N'Guessan, Kre N’Guessan Raymond, Laboratoire de Physique Fondamentale et Appliquée , Abidjan , Côte d’Ivoire
Publikováno v:
SDRP Journal of Computational Chemistry & Molecular Modeling. 5:585-600
We report here virtual design of new anthranilic acid derivatives (AAD) identified as potent partial Farnesoid X recep-tor (FXR) agonists with favorable predicted pharmacokinetic profiles. By in situ modification of the crystal structure (PDB ID: 3OL