Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Guy Lemay"'
Autor:
Zhenlong Liu, Émilie Larocque, Yongli Xie, Yong Xiao, Guy Lemay, Jean-Marie Peloponese, Jean-Michel Mesnard, Éric Rassart, Rongtuan Lin, Shuang Zhou, Yiming Zeng, Hongzhi Gao, Shan Cen, Benoit Barbeau
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Human T-cell leukemia virus type 1 is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia-lymphoma (ATL). The HTLV-1 basic leucine zipper factor (HBZ) has been associated to the cancer-inducing p
Externí odkaz:
https://doaj.org/article/0f8ce197a8284805aad65f31716bb1d0
Publikováno v:
Viruses, Vol 14, Iss 12, p 2710 (2022)
The spliceosome is a massive ribonucleoprotein structure composed of five small nuclear ribonucleoprotein (snRNP) complexes that catalyze the removal of introns from pre-mature RNA during constitutive and alternative splicing. EFTUD2, PRPF8, and SNRN
Externí odkaz:
https://doaj.org/article/14631799079a4e098a34fa8053b2e908
Autor:
Simon Boudreault, Carole-Anne Martineau, Laurence Faucher-Giguère, Sherif Abou-Elela, Guy Lemay, Martin Bisaillon
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 727 (2022)
Mammalian orthoreovirus (MRV) is a double-stranded RNA virus from the Reoviridae family that infects a large range of mammals, including humans. Recently, studies have shown that MRV alters cellular alternative splicing (AS) during viral infection. T
Externí odkaz:
https://doaj.org/article/35f29a93135b43dea8232e3ea7808744
Publikováno v:
Viruses, Vol 14, Iss 12, p 2638 (2022)
It has been previously shown that amino acid polymorphisms in reovirus proteins μ2 and λ1 are associated with differing levels of interferon induction. In the present study, viruses carrying these polymorphisms in either or both proteins, were furt
Externí odkaz:
https://doaj.org/article/7ca8dea8381e424d997b082851406523
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221505 (2019)
The lentiviral Rev protein, which is a regulatory protein essential for virus replication, has been first studied in the human immunodeficiency virus type 1 (HIV-1). The main function of Rev is to mediate the nuclear exportation of viral RNAs. To ful
Externí odkaz:
https://doaj.org/article/1866d821783a4b52a24c82e25934a26f
Publikováno v:
Pathogens, Vol 8, Iss 2, p 83 (2019)
As with most viruses, mammalian reovirus can be recognized and attacked by the host-cell interferon response network. Similarly, many viruses have developed resistance mechanisms to counteract the host-cell response at different points of this respon
Externí odkaz:
https://doaj.org/article/c542119033404956915fbd4861147f8e
Synthesis and Translation of Viral mRNA in Reovirus-Infected Cells: Progress and Remaining Questions
Autor:
Guy Lemay
Publikováno v:
Viruses, Vol 10, Iss 12, p 671 (2018)
At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of s
Externí odkaz:
https://doaj.org/article/05c1fa1680e74378aa2e7f502fd648ca
Autor:
Simon Boudreault, Camille Martenon-Brodeur, Marie Caron, Jean-Michel Garant, Marie-Pier Tremblay, Victoria E S Armero, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Guy Lemay, Martin Bisaillon
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161914 (2016)
Alternative splicing (AS) is a central mechanism of genetic regulation which modifies the sequence of RNA transcripts in higher eukaryotes. AS has been shown to increase both the variability and diversity of the cellular proteome by changing the comp
Externí odkaz:
https://doaj.org/article/4efaed8b114a43f8b28456312b3e7e0c
Autor:
Simon Boudreault, Mathieu Durand, Carole-Anne Martineau, Jean-Pierre Perreault, Guy Lemay, Martin Bisaillon
Publikováno v:
Nucleic Acids Research. 50:5263-5281
Mammalian orthoreovirus (MRV) is a double-stranded RNA virus from the Reoviridae family presenting a promising activity as an oncolytic virus. Recent studies have underlined MRV’s ability to alter cellular alternative splicing (AS) during infection
Autor:
Guy, Lemay
Publikováno v:
Virologie (Montrouge, France). 15(1)
In "classical" genetics, examination of a phenotype leads to the study of the gene(s) involved in its obtention. Reverse genetics is a powerful experimental approach in which, on the contrary, the genetic material is modified and used to reconstruct