Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Guy Las"'
Autor:
Essam A. Assali, Anthony E. Jones, Michaela Veliova, Rebeca Acín-Pérez, Mahmoud Taha, Nathanael Miller, Michaël Shum, Marcus F. Oliveira, Guy Las, Marc Liesa, Israel Sekler, Orian S. Shirihai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of
Externí odkaz:
https://doaj.org/article/b7d8f16459e24177b94890292b6533d2
Autor:
Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau, Guy Las, Marc Liesa, Orian S Shirihai, Lawreen H Connors, David C Seldin, Rodney H Falk, Calum A MacRae, Ronglih Liao
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 11, Pp 1493-1507 (2014)
Abstract AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy. Recent work has found that amyloidogenic LC directly
Externí odkaz:
https://doaj.org/article/17dcf5efbb874bc4b530c037fafd54f5
Autor:
Guy Las, Orian Shirihai
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 805-806 (2016)
Externí odkaz:
https://doaj.org/article/fb43b735774748fab47ff5bb5449525a
Autor:
Jian Guan, Shikha Mishra, Yiling Qiu, Jianru Shi, Kyle Trudeau, Guy Las, Marc Liesa, Orian S Shirihai, Lawreen H Connors, David C Seldin, Rodney H Falk, Calum A MacRae, Ronglih Liao
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 5, Pp 688-688 (2015)
Externí odkaz:
https://doaj.org/article/ce3331e289de475dae37ee8418bae05d
Autor:
Orian S. Shirihai, Eli C. Lewis, Haim Barr, Anton Petcherski, Guy Las, Essam A. Assali, Noga Kozer, Boris M. Baranovski, Roi Gazit, Dane M. Wolf, Fernanda M. Cerqueira, Yaelle Roth
Publikováno v:
Biochemical Journal. 477:461-475
Mitochondrial turnover is required for proper cellular function. Both mitochondrial biogenesis and mitophagy are impaired in several degenerative and age-related diseases. The search for mitophagy activators recently emerged as a new therapeutical ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382f432bf9c790682d69a09ecf3abfa9
https://doi.org/10.1042/bcj20190616
https://doi.org/10.1042/bcj20190616
Publikováno v:
Molecular aspects of medicine. 71
Type-2-Diabetes (T2D) is the most common metabolic disease in the world today. It erupts as a result of peripheral insulin resistance combined with hyperinsulinemia followed by suppression of insulin secretion from pancreatic β-cells. Mitochondria p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf22112eaae61b0c9426bd6cffa6eaec
https://pubmed.ncbi.nlm.nih.gov/31918997
https://pubmed.ncbi.nlm.nih.gov/31918997
Autor:
Aaron H. Colby, Karel A. Erion, Mark W. Grinstaff, Dovi Shlomo, Marc Liesa, Jialiu Zeng, Orian S. Shirihai, Kyle Trudeau, Guy Las, Essam A. Assali, Evan P. Taddeo
Publikováno v:
FASEB J
Chronic exposure of pancreatic β cells to high concentrations of free fatty acids leads to lipotoxicity (LT)‐mediated suppression of glucose‐stimulated insulin secretion. This effect is in part caused by a decline in mitochondrial function as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccf94261cdb5bbac13f59a3b9d381fd
https://pubmed.ncbi.nlm.nih.gov/30550357
https://pubmed.ncbi.nlm.nih.gov/30550357
Autor:
Jialiu Zeng, Jiazuo H. Feng, Kyle Trudeau, Aaron H. Colby, Mark W. Grinstaff, Orian S. Shirihai, Guy Las
Publikováno v:
The Journal of Cell Biology
Lipotoxicity is frequently associated with alkalinization of lysosomes and impaired autophagic flux but the relationship between the two is unclear. Trudeau et al. show that autophagic flux can be restored in β islet cells chronically exposed to fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38178b668118b9883530c4c4dd84591
http://europepmc.org/articles/PMC4932370
http://europepmc.org/articles/PMC4932370
Autor:
Marc Liesa, Guy Las, Essam A. Assali, Marcus F. Oliveira, Michael Shum, Rebeca Acín-Pérez, Orian S. Shirihai, Anthony E. Jones, Israel Sekler, Michaela Veliova, Nathanael Miller, Mahmoud Taha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
A sharp increase in mitochondrial Ca2+marks the activation of the brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca2+deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb28e5dce1828800adb13e7c05ee13f
Autor:
Sapir Bechor, Maayan Vatarescu, Guy Las, Tanya Tarnovscki, Natalie Elia, Assaf Rudich, Martin Gericke, Yulia Haim, Alicia Leikin-Frenkel, Dikla Nachmias
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(9)
Obesity promotes the biogenesis of adipose tissue (AT) foam cells (FC), which contribute to AT insulin resistance. Autophagy, an evolutionarily-conserved house-keeping process, was implicated in cellular lipid handling by either feeding and/or degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852a92f98aa87098047e24f7f031b237
https://pubmed.ncbi.nlm.nih.gov/28652194
https://pubmed.ncbi.nlm.nih.gov/28652194