Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Guy L Odom"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009179 (2020)
Gene therapy approaches for DMD using recombinant adeno-associated viral (rAAV) vectors to deliver miniaturized (or micro) dystrophin genes to striated muscles have shown significant progress. However, concerns remain about the potential for immune r
Externí odkaz:
https://doaj.org/article/72d23454fd4f4c8facce98929e058859
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004431 (2014)
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by mutations in the dystrophin gene. To examine the influence of muscle structure on the pathogenesis of DMD we generated mdx4cv:desmin double knockout (dko) mice. The dko m
Externí odkaz:
https://doaj.org/article/b5ea6b9ead3d43d9b81617310c1deae7
Autor:
Marcelo dos Santos Voltani Lorena, Estela Kato dos Santos, Renato Ferretti, G. A. Nagana Gowda, Guy L. Odom, Jeffrey S. Chamberlain, Cintia Yuri Matsumura
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Background Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy without an effective treatment, caused by mutations in the DMD gene, leading to the absence of dystrophin. DMD results in muscle weakness, loss of ambulation
Externí odkaz:
https://doaj.org/article/bee194a80f0f4dbb94252899775bccf4
Autor:
Arden B. Piepho, Jeovanna Lowe, Laurel R. Cumby, Lisa E. Dorn, Dana M. Lake, Neha Rastogi, Megan D. Gertzen, Sarah L. Sturgill, Guy L. Odom, Mark T. Ziolo, Federica Accornero, Jeffrey S. Chamberlain, Jill A. Rafael-Fortney
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 344-354 (2023)
Micro-dystrophin gene replacement therapies for Duchenne muscular dystrophy (DMD) are currently in clinical trials, but have not been thoroughly investigated for their efficacy on cardiomyopathy progression to heart failure. We previously validated F
Externí odkaz:
https://doaj.org/article/112376132c914e0588ee19091b2c6a91
Autor:
Ketaki N Mhatre, Julie Mathieu, Amy Martinson, Galina Flint, Leslie P. Blakley, Arash Tabesh, Hans Reinecke, Xiulan Yang, Xuan Guan, Eesha Murali, Jordan M Klaiman, Guy L Odom, Mary Beth Brown, Rong Tian, Stephen D Hauschka, Daniel Raftery, Farid Moussavi-Harami, Michael Regnier, Charles E Murry
Transplanted human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) improve ventricular performance when delivered acutely post-myocardial infarction but are ineffective in chronic myocardial infarction/heart failure. 2’-deoxy-ATP (dATP) act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e665b470ba9e0494d5530ab7fecca44b
https://doi.org/10.1101/2023.04.24.538108
https://doi.org/10.1101/2023.04.24.538108
Autor:
John K. Hall, Farid Moussavi-Harami, Stephen C. Kolwicz, Jeffrey S. Chamberlain, Stephen D. Hauschka, Xiolan Chen, Michael Regnier, Guy L. Odom
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 778-791 (2019)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • rAAV vectors increase cardiac-specific expression of RNR and elevate cardiomyocyte 2-dATP levels. • Elevated myocardial RNR and subsequent increase in 2-dATP rescues the performance of failing myocardium, an effe
Highlights • rAAV vectors increase cardiac-specific expression of RNR and elevate cardiomyocyte 2-dATP levels. • Elevated myocardial RNR and subsequent increase in 2-dATP rescues the performance of failing myocardium, an effe
Autor:
Neha Rastogi, Lisa E. Dorn, Megan D. Gertzen, Jeovanna Lowe, Zachary M. Howard, Guy L. Odom, Jill A. Rafael-Fortney, Jeffrey S. Chamberlain, Federica Accornero, Pierce C. Ciccone
Publikováno v:
JCI Insight, Vol 6, Iss 7 (2021)
JCI Insight
JCI Insight
Gene replacement for Duchenne muscular dystrophy (DMD) with micro-dystrophins has entered clinical trials, but efficacy in preventing heart failure is unknown. Although most patients with DMD die from heart failure, cardiomyopathy is undetectable unt
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009179 (2020)
PLoS Genetics, Vol 16, Iss 11, p e1009179 (2020)
Gene therapy approaches for DMD using recombinant adeno-associated viral (rAAV) vectors to deliver miniaturized (or micro) dystrophin genes to striated muscles have shown significant progress. However, concerns remain about the potential for immune r
Autor:
Jeffrey S. Chamberlain, Charles E. Murry, Gregory G. Mahairas, Sam L. Teichman, Guy L. Odom, Farid Moussavi-Harami, Stephen D. Hauschka, Kassandra S. Thomson, Xiaolan Chen, Michael Regnier
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 666-679 (2016)
Summary Despite recent advances, chronic heart failure remains a significant and growing unmet medical need, reaching epidemic proportions carrying substantial morbidity, mortality, and costs. A safe and convenient therapeutic agent that produces sus
Autor:
Min Jeong Kim, Kenneth L. Bible, Stanley C. Froehner, Nicholas P. Whitehead, Guy L. Odom, Marvin E. Adams
Publikováno v:
The Journal of Physiology. 594:7215-7227
Key points Duchenne muscular dystrophy (DMD) is a severe, degenerative muscle disease that is commonly studied using the mdx mouse. The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD muscles. mdx diaphragm force is commonly