Výsledky vyhledávání

Centrioles resist forces applied on centrosomes during G2/M transition

Autor: Michel Bornens, Miguel Abal, Guy Keryer

Publikováno v: Biology of the Cell. 97:425-434

Background information. Centrosome movements at the onset of mitosis result from a balance between the pulling and pushing forces mediated by microtubules. The structural stability of the centrosome core structure, the centriole pair, is correlated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0512ce6190a5f261ab51befe4f1237
https://doi.org/10.1042/bc20040112

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Part of Ran Is Associated with AKAP450 at the Centrosome: Involvement in Microtubule-organizing Activity

Autor: Karl-Ferdinand Lechtreck, Mette M. Mogensen, Guy Keryer, Annie Delouvée, Barbara Di Fiore, Anne-Marie Tassin, Claude Celati, Patrizia Lavia, Michel Bornens

Publikováno v: Molecular Biology of the Cell. 14:4260-4271

The small Ran GTPase, a key regulator of nucleocytoplasmic transport, is also involved in microtubule assembly and nuclear membrane formation. Herein, we show by immunofluorescence, immunoelectron microscopy, and biochemical analysis that a fraction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a3bb950deda8be84da5a6aa96d4c63
https://doi.org/10.1091/mbc.e02-11-0773

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CDK1-mediated phosphorylation of the RIIα regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIα from centrosomes at mitosis

Autor: Philippe Collas, Friedrich W. Herberg, Cathrine R. Carlson, Lutz Vossebein, Kjetil Taskén, Bjørn Steen Skålhegg, Jean-Claude Labbé, Guy Keryer, Oliwia Witczak

Publikováno v: Journal of Cell Science. 114:3243-3254

Protein kinase A regulatory subunit RIIalpha is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP450, but dissociates and redistributes from centrosomes at mitosis. The cyclin B-p34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ba44b1161a3f0a1a2c21c8de101347
https://doi.org/10.1242/jcs.114.18.3243

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Role of cyclic AMP-dependent protein kinases in human villous cytotrophoblast differentiation

Autor: Guy Keryer, Danièle Evain-Brion, E. Alsat, Kjetil Taskén

Publikováno v: Placenta. 19:295-314

Summary Human trophoblast cells offer a unique in vitro model to study aspects of the dynamic processes occuring during cell fusion and syncytium formation. In the human placenta, mononuclear cytotrophoblasts aggregate and fuse to form a multinucleat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f3a968d2ee9626845ea06686e94ee68
https://doi.org/10.1016/s0143-4004(98)80050-7

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Purification of the surface membrane-cytoskeleton complex (Cortex) of Paramecium and identification of several of its protein constituents

Autor: Michèle Rossignol, Nicole Stelly, André Adoutte, Janine Beisson, Jean Cohen, Stephen F. Ng, Nicole Garreau de Loubresse, Guy Keryer

Publikováno v: European journal of protistology. 25(3)

Summary In ciliates, the major morphogenetic events take place in the cortex, a complex of membranes and closely associated filamentous networks. To analyze the problems of assembly and morphogenesis at the molecular level in Paramecium , we have dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3664a65f9863597b99ddbe255db3dcfc
https://pubmed.ncbi.nlm.nih.gov/23195967

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Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Autor: Nathalie Spassky, Karen M. Smith, Robert J. Ferrante, Ioannis Dragatsis, Frédéric Saudou, Jose R. Pineda, Jinho Kim, Paula Dietrich, Guy Keryer, Géraldine Liot, Caroline Benstaali, Fabrice P. Cordelières

Huntington disease (HD) is a devastating autosomal-dominant neurodegenerative disorder. It is caused by expansion of a CAG repeat in the first exon of the huntingtin (HTT) gene that encodes a mutant HTT protein with a polyglutamine (polyQ) expansion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aa360f6c849aabfc3e62aa9f536a62
https://europepmc.org/articles/PMC3223861/

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Huntingtin Is Required for Mitotic Spindle Orientation and Mammalian Neurogenesis

Autor: Sandrine Humbert, Béé Edicte C. Charrin, Yohanns Bellaïche, Juliette D. Godin, Maria Molina-Calavita, Laurent Nguyen, Guy Keryer, Kelly Colombo, Diana Zala, Marie Laure Volvert, François Guillemot, Paula Dietrich, Ioannis Dragatsis, Frédéric Saudou

Publikováno v: Neuron
Neuron, Elsevier, 2010, 67 (3), pp.392-406. ⟨10.1016/j.neuron.2010.06.027⟩

SummaryHuntingtin is the protein mutated in Huntington's disease, a devastating neurodegenerative disorder. We demonstrate here that huntingtin is essential to control mitosis. Huntingtin is localized at spindle poles during mitosis. RNAi-mediated si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81551f9cbb819874411cf2f658c1f3e3
https://hal.archives-ouvertes.fr/hal-03373901

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pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking

Autor: Raul Pardo, Frédéric Saudou, Ghislaine Poizat, Sandrine Humbert, Maria Molina-Calavita, Guy Keryer

Publikováno v: Molecular Brain
Molecular Brain, 2010, 3 (1), pp.17. ⟨10.1186/1756-6606-3-17⟩
Molecular Brain, BioMed Central, 2010, 3 (1), pp.17. ⟨10.1186/1756-6606-3-17⟩
Molecular Brain, Vol 3, Iss 1, p 17 (2010)

Background Huntingtin (htt) is a multi-domain protein of 350 kDa that is mutated in Huntington's disease (HD) but whose function is yet to be fully understood. This absence of information is due in part to the difficulty of manipulating large DNA fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565bdc8d62cf18938f1210b2d829bea7
https://hal.science/hal-03297486

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Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts

Autor: Guy Keryer, Michel Bornens, S M Lohmann, Claude Celati, R M Rios

Publikováno v: The EMBO Journal. 11:1723-1731

Immunocytochemical evidence of an association between the regulatory subunit RII of the cAMP-dependent protein kinase (cAMP-PK) and the Golgi apparatus in several cell types has been reported. In order to identify endogenous Golgi proteins binding RI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a539ad1f65c3e548c2e85a5b236fab
https://doi.org/10.1002/j.1460-2075.1992.tb05224.x

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Cortical morphogenesis in Paramecium: A transcellular wave of protein phosphorylation involved in ciliary rootlet disassembly

Autor: Linda Sperling, Janine Beisson, Guy Keryer, Françoise Ruiz

Publikováno v: Developmental Biology. 148:205-218

In Paramecium, the morphogenesis of the cortex at cell division, which assures reconstruction of shape and surface pattern, has been shown to involve transcellular signals which spread across the cortex like a wave, originating principally from the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2967aa2aa02948118847e24eda3100f4
https://doi.org/10.1016/0012-1606(91)90330-6

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