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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Autor: Nico Ghilardi, Andrea M. Cooper, Santiago Partida-Sanchez, Shabaana A. Khader, Guy K. Bell, Susan L. Swain, Frederic Desauvage, Frances E. Lund, Dawn M. Jelley-Gibbs, John E. Pearl

Publikováno v: The Journal of Experimental Medicine

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f02519e9d74956eac15136d826a44
https://doi.org/10.1084/jem.20052545

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IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

Autor: Susan L. Swain, Shabaana A. Khader, Sheri M. Eaton, Jeffrey J. Fountain, Richard M. Locksley, Laura Haynes, Guy K. Bell, Garth E Cilley, Troy D. Randall, Javier Rangel-Moreno, Fang Shen, Andrea M. Cooper, John E. Pearl, Sarah L. Gaffen

Publikováno v: Nature immunology. 8(4)

Interferon-gamma is key in limiting Mycobacterium tuberculosis infection. Here we show that vaccination triggered an accelerated interferon-gamma response by CD4(+) T cells in the lung during subsequent M. tuberculosis infection. Interleukin 23 (IL-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ff5545933f8980744912fd6a45653e
https://pubmed.ncbi.nlm.nih.gov/17351619

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IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available

Autor: John E. Pearl, Kaori Sakamoto, Shabaana A. Khader, Andrea M. Cooper, Fred deSauvage, Guy K. Bell, Nico Ghilardi, Leigh Gilmartin, Dawn M. Jelley-Gibbs

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 175(2)

IL-12p70 induced IFN-γ is required to control Mycobacterium tuberculosis growth; however, in the absence of IL-12p70, an IL-12p40-dependent pathway mediates induction of IFN-γ and initial bacteriostatic activity. IL-23 is an IL-12p40-dependent cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c7703e70958f9289af2d06ef807d9c
https://pubmed.ncbi.nlm.nih.gov/16002675

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