Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Guy Georges"'
Autor:
Brennan Abanades, Wing Ki Wong, Fergus Boyles, Guy Georges, Alexander Bujotzek, Charlotte M. Deane
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract Immune receptor proteins play a key role in the immune system and have shown great promise as biotherapeutics. The structure of these proteins is critical for understanding their antigen binding properties. Here, we present ImmuneBuilder, a
Externí odkaz:
https://doaj.org/article/b37c7d7563ae4ca08664f3fcb307a9cb
Autor:
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty, Andreas H. Laustsen
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBeyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures. Here, we review
Externí odkaz:
https://doaj.org/article/40e1d35a06264ee9a178e72c2e9b24b1
Autor:
Fabian C. Spoendlin, Brennan Abanades, Matthew I. J. Raybould, Wing Ki Wong, Guy Georges, Charlotte M. Deane
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The function of an antibody is intrinsically linked to the epitope it engages. Clonal clustering methods, based on sequence identity, are commonly used to group antibodies that will bind to the same epitope. However, such methods neglect the fact tha
Externí odkaz:
https://doaj.org/article/663f4ddb281445ba9237b0f9438709b0
Autor:
Franz Waibl, Monica L. Fernández-Quintero, Florian S. Wedl, Hubert Kettenberger, Guy Georges, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
While antibody-based therapeutics have grown to be one of the major classes of novel medicines, some antibody development candidates face significant challenges regarding expression levels, solubility, as well as stability and aggregation, under phys
Externí odkaz:
https://doaj.org/article/8b0bdc4c923f411f9bbae0b02b7643c8
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/863a1215e8194a08a42b208a8195a801
Autor:
Stefan Dengl, Klaus Mayer, Felix Bormann, Harald Duerr, Eike Hoffmann, Bianca Nussbaum, Michael Tischler, Martina Wagner, Andreas Kuglstatter, Lea Leibrock, Can Buldun, Guy Georges, Ulrich Brinkmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bispecific antibodies have been generated in many different formats and it is becoming clear that rational design alone cannot create optimal functionalities. Here the authors introduce the high throughput methodology, Format Chain Exchange (FORCE),
Externí odkaz:
https://doaj.org/article/2e93ad508e924c6e932a762afd54dddb
Autor:
Monica L. Fernández-Quintero, Patrick K. Quoika, Florian S. Wedl, Clarissa A. Seidler, Katharina B. Kroell, Johannes R. Loeffler, Nancy D. Pomarici, Valentin J. Hoerschinger, Alexander Bujotzek, Guy Georges, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
As the current biotherapeutic market is dominated by antibodies, the design of different antibody formats, like bispecific antibodies and other new formats, represent a key component in advancing antibody therapy. When designing new formats, a target
Externí odkaz:
https://doaj.org/article/54e0f0f4d5ce4f6eb11bbfda2d108352
Autor:
Monica L. Fernández-Quintero, Katharina B. Kroell, Lisa M. Bacher, Johannes R. Loeffler, Patrick K. Quoika, Guy Georges, Alexander Bujotzek, Hubert Kettenberger, Klaus R. Liedl
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins. To improve the rational design of antibodies, we investigate the conformational diversity of 16 different germline combinations, which are composed of 4 differe
Externí odkaz:
https://doaj.org/article/c9ed751bd030469cb8cfaa67c3de38a9
Autor:
Wing Ki Wong, Sarah A. Robinson, Alexander Bujotzek, Guy Georges, Alan P. Lewis, Jiye Shi, James Snowden, Bruck Taddese, Charlotte M. Deane
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Solving the structure of an antibody-antigen complex gives atomic level information of the interactions between an antibody and its antigen, but such structures are expensive and hard to obtain. Alternative experimental sources include epitope mappin
Externí odkaz:
https://doaj.org/article/efd55cb0505346a09833b01bd619abde
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
The rise of antibodies as a promising and rapidly growing class of biotherapeutic proteins has motivated numerous studies to characterize and understand antibody structures. In the past decades, the number of antibody crystal structures increased sub
Externí odkaz:
https://doaj.org/article/c49be9942652405b9dd4a4e8539abc52