Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Guy G. Poirier"'
Autor:
Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs
Externí odkaz:
https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f7
Autor:
Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit K. Sharma, Michael J. Hendzel, Jean-Yves Masson, Guy G. Poirier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
ADP-ribose erasing enzymes are increasingly recognized as critical regulators of protein ADP-ribosylation dynamics in living systems. Here, the authors review recent advances in the discovery and characterization of ADP-ribose erasers and discuss the
Externí odkaz:
https://doaj.org/article/05d8f39e0141460487e8fe00b0a3d6e4
Autor:
Anna Maggiore, Assunta Maria Casale, Walter Toscanelli, Ugo Cappucci, Dante Rotili, Maddalena Grieco, Jean-Philippe Gagné, Guy G. Poirier, Maria d’Erme, Lucia Piacentini
Publikováno v:
Cells, Vol 11, Iss 8, p 1284 (2022)
Alzheimer’s disease (AD) is an irreversible age-related neurodegenerative disorder clinically characterized by severe memory impairment, language deficits and cognitive decline. The major neuropathological hallmarks of AD include extracellular depo
Externí odkaz:
https://doaj.org/article/d9116e09e0184c0386e791bb036e7ba2
Autor:
Martin Perreault, Ewa Wunsch, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Guy G. Poirier, Piotr Milkiewicz, Olivier Barbier
Publikováno v:
Canadian Journal of Gastroenterology and Hepatology, Vol 2018 (2018)
Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography cou
Externí odkaz:
https://doaj.org/article/44bc62132e724ccf9880ac942487bb6a
Autor:
Denis Velic, Anthony M. Couturier, Maria Tedim Ferreira, Amélie Rodrigue, Guy G. Poirier, Fabrice Fleury, Jean-Yves Masson
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 3204-3259 (2015)
For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is bo
Externí odkaz:
https://doaj.org/article/4f2b0fefb4634be288e144c58e4225c7
ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Autor:
Elise Fouquerel, Eva M. Goellner, Zhongxun Yu, Jean-Philippe Gagné, Michelle Barbi de Moura, Tim Feinstein, David Wheeler, Philip Redpath, Jianfeng Li, Guillermo Romero, Marie Migaud, Bennett Van Houten, Guy G. Poirier, Robert W. Sobol
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1819-1831 (2014)
ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated wit
Externí odkaz:
https://doaj.org/article/57881395c3964d75997386db9b9b638b
Autor:
Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Henry Bannister, Hai Dang Nguyen, Caroline Curry, John M Pascal, Guy G Poirier, Hong Wang, Jean-Yves Masson, Elise Fouquerel
Publikováno v:
Nucleic Acids Research. 51:2215-2237
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a component of the R-loop-associated protein-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9794ea96a99f58725bc1bece03fd0ed
https://doi.org/10.1093/nar/gkad066
https://doi.org/10.1093/nar/gkad066
Autor:
M Iqbal Hossain, Jun Hee Lee, Jean-Philippe Gagne, Junaid Khan, Guy G Poirier, Valina L Dawson, Ted M Dawson, Shaida A Anadrabi
PARP-1 over-activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis, mitochondrial function, and redox balance are key cellular processes altered in brain ischemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9d578b6058d8bd0942d157679c50a6
https://doi.org/10.1101/2023.05.30.542910
https://doi.org/10.1101/2023.05.30.542910
Autor:
Scott H. Kaufmann, Paul Haluska, Charles Erlichman, Yiping Zang, Jiuping Ji, Alice Chen, Janet L. Lensing, Jake Allred, Daniel Satele, Guy G. Poirier, Elizabeth M. Swisher, Maria I. Harrell, Karen S. Flatten, Olumide Kayode, Felix Boakye-Agyeman, Joel M. Reid, Donald W. Northfelt, Harry J. Long, Lynn C. Hartmann, Michael E. Menefee, Andrea E. Wahner Hendrickson
Supplementary Data from A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe758551259fc408446ac87e6688495
https://doi.org/10.1158/1078-0432.22464845
https://doi.org/10.1158/1078-0432.22464845