Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Guy E Thwaites"'
Autor:
Hoang Thanh Hai, Le Thanh Hoang Nhat, Trinh Thi Bich Tram, Do Dinh Vinh, Artika P Nath, Joseph Donovan, Nguyen Thi Anh Thu, Dang Van Thanh, Nguyen Duc Bang, Dang Thi Minh Ha, Nguyen Hoan Phu, Ho Dang Trung Nghia, Le Hong Van, Michael Inouye, Guy E Thwaites, Nguyen Thuy Thuong Thuong
Publikováno v:
eLife, Vol 13 (2024)
Mortality and morbidity from tuberculous meningitis (TBM) are common, primarily due to inflammatory response to Mycobacterium tuberculosis infection, yet the underlying mechanisms remain poorly understood. We aimed to uncover genes and pathways assoc
Externí odkaz:
https://doaj.org/article/bc95681a731846ba918190c3d7e3cad9
Autor:
Srinivasan Vijay, Nguyen Le Hoai Bao, Dao Nguyen Vinh, Le Thanh Hoang Nhat, Do Dang Anh Thu, Nguyen Le Quang, Le Pham Tien Trieu, Hoang Ngoc Nhung, Vu Thi Ngoc Ha, Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Huu Lan, Maxine Caws, Guy E Thwaites, Babak Javid, Nguyen Thuy Thuong
Publikováno v:
eLife, Vol 13 (2024)
Antibiotic tolerance in Mycobacterium tuberculosis reduces bacterial killing, worsens treatment outcomes, and contributes to resistance. We studied rifampicin tolerance in isolates with or without isoniazid resistance (IR). Using a minimum duration o
Externí odkaz:
https://doaj.org/article/3b8a06ec8c904a9c82bb9d877cf08e28
Autor:
Duc Hong Du, Ronald B Geskus, Yanlin Zhao, Luigi Ruffo Codecasa, Daniela Maria Cirillo, Reinout van Crevel, Dyshelly Nurkartika Pascapurnama, Lidya Chaidir, Stefan Niemann, Roland Diel, Shaheed Vally Omar, Louis Grandjean, Sakib Rokadiya, Arturo Torres Ortitz, Nguyễn Hữu Lân, Đặng Thị Minh Hà, E Grace Smith, Esther Robinson, Martin Dedicoat, Le Thanh Hoang Nhat, Guy E Thwaites, Le Hong Van, Nguyen Thuy Thuong Thuong, Timothy M Walker
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 8, p e0003674 (2024)
[This corrects the article DOI: 10.1371/journal.pgph.0001788.].
Externí odkaz:
https://doaj.org/article/5c902d7712ed44d3a63852b7aabd25f3
Autor:
Nguyen Thi Hoang Mai, Nicholas Dobbs, Nguyen Hoan Phu, Romain A Colas, Le TP Thao, Nguyen TT Thuong, Ho DT Nghia, Nguyen HH Hanh, Nguyen T Hang, A Dorothee Heemskerk, Jeremy N Day, Lucy Ly, Do DA Thu, Laura Merson, Evelyne Kestelyn, Marcel Wolbers, Ronald Geskus, David Summers, Nguyen VV Chau, Jesmond Dalli, Guy E Thwaites
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/cd4e0a5cd9fb4497a8a9948b8fd56585
Autor:
Duc Hong Du, Ronald B Geskus, Yanlin Zhao, Luigi Ruffo Codecasa, Daniela Maria Cirillo, Reinout van Crevel, Dyshelly Nurkartika Pascapurnama, Lidya Chaidir, Stefan Niemann, Roland Diel, Shaheed Vally Omar, Louis Grandjean, Sakib Rokadiya, Arturo Torres Ortitz, Nguyễn Hữu Lân, Đặng Thị Minh Hà, E Grace Smith, Esther Robinson, Martin Dedicoat, Le Thanh Hoang Nhat, Guy E Thwaites, Le Hong Van, Nguyen Thuy Thuong Thuong, Timothy M Walker
Publikováno v:
PLOS Global Public Health, Vol 3, Iss 12, p e0001788 (2023)
Six lineages of Mycobacterium tuberculosis sensu stricto (which excludes M. africanum) are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and clinical phenot
Externí odkaz:
https://doaj.org/article/3e1033c2e23f45f384d8e5166dd225e4
Autor:
Barnaby Flower, Le Manh Hung, Leanne Mccabe, M Azim Ansari, Chau Le Ngoc, Thu Vo Thi, Hang Vu Thi Kim, Phuong Nguyen Thi Ngoc, Le Thanh Phuong, Vo Minh Quang, Thuan Dang Trong, Thao Le Thi, Tran Nguyen Bao, Cherry Kingsley, David Smith, Richard M Hoglund, Joel Tarning, Evelyne Kestelyn, Sarah L Pett, Rogier van Doorn, Jennifer Ilo Van Nuil, Hugo Turner, Guy E Thwaites, Eleanor Barnes, Motiur Rahman, Ann Sarah Walker, Jeremy N Day, Nguyen VV Chau, Graham S Cooke
Publikováno v:
eLife, Vol 12 (2023)
Background: World Health Organization has called for research into predictive factors for selecting persons who could be successfully treated with shorter durations of direct-acting antiviral (DAA) therapy for hepatitis C. We evaluated early virologi
Externí odkaz:
https://doaj.org/article/3ba314b4797945c5a31bd2030707b7a6
Autor:
Nguyen Thi Thuy Ngan, Nhat Thanh Hoang Le, Nguyen Ngo Vi Vi, Ninh Thi Thanh Van, Nguyen Thi Hoang Mai, Duong Van Anh, Phan Hai Trieu, Nguyen Phu Huong Lan, Nguyen Hoan Phu, Nguyen Van Vinh Chau, David G Lalloo, William Hope, Justin Beardsley, Nicholas J White, Ronald Geskus, Guy E Thwaites, Damian Krysan, Luong Thi Hue Tai, Evelyne Kestelyn, Tran Quang Binh, Le Quoc Hung, Nguyen Le Nhu Tung, Jeremy N Day
Publikováno v:
eLife, Vol 10 (2021)
Background: Cryptococcal meningitis has high mortality. Flucytosine is a key treatment but is expensive and rarely available. The anticancer agent tamoxifen has synergistic anti-cryptococcal activity with amphotericin in vitro. It is off-patent, chea
Externí odkaz:
https://doaj.org/article/d269e628c20f4c23bdcbb1467de9eb04
Autor:
H Rogier van Doorn, Guy E Thwaites, Evelyne Kestelyn, Quang Ngo Nguyen, Nam Vinh Nguyen, Dung Thi Phuong Nguyen, Celine Vidaillac, Phuong Thi Minh Trinh, Ha Thi Nhi Vo
Publikováno v:
BMJ Open, Vol 11, Iss 7 (2021)
Background Assessing the capacity of a healthcare institution to conduct and manage clinical research studies is challenging, especially in developing countries where resources are limited. The objective of this study was to develop a practical and t
Externí odkaz:
https://doaj.org/article/a44bb76d0e6c4f0bb684506d2cabfc4b
Autor:
Nathan C Bahr, Fiona V Cresswell, Nguyen Thuy Thuong Thuong, Rachel P.J. Lai, Angharad G. Davis, David R Boulware, Robert J Wilkinson, Johan Schoeman, Marise Bremer, Joseph Donovan, Ronald Van Toorn, Guy E Thwaites, Ariba Dadabhoy
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective host directed therapies (HDTs) are critical to improve survival and clinical outcomes. Currently only one HDT, dexamet
Externí odkaz:
https://doaj.org/article/1082f9028b78463baff862754b13c9a1
Autor:
Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll, Paul H Edelstein, Roger Sewell, Lalita Ramakrishnan
Publikováno v:
eLife, Vol 10 (2021)
Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam,
Externí odkaz:
https://doaj.org/article/e5091ac19b1c47789b6044b32485ac7f