Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

Autor: Thierry Huet, Guy Dubreucq, Romain Mazinghien, Heidi Bompais, Loïc Vincent, Maurice Petitou, Arnaud Salvador, Jérôme Lemoine, Jan Balzarini, Cécile Gauchet, Olivier Querolle, Pascal Clayette, Dominique Schols, Bruno Lucidi, Olivier Kerbarh

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:134-142

Enfuvirtide (also known as Fuzeon, T-20, or DP-178) is an antiretroviral fusion inhibitor which prevents human immunodeficiency virus type 1 (HIV-1) from entering host cells. This linear 36-mer synthetic peptide is indicated, in combination with othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7d17aedc7e1f5327a73158280ea973
https://doi.org/10.1128/aac.00827-09

From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile

Autor: Jeffry A. J. Wisse, Maurice Petitou, Vanessa Nancy-Portebois, D.G. Meuleman, Martin de Kort, Constant A. A. van Boeckel, Gerard M. T. Vogel, Vincent Motte, Guy Dubreucq

Publikováno v: Thrombosis and Haemostasis, 102(5), 804-810. Schattauer GmbH

SummaryThe elucidation of the structure of the antithrombin binding sequence in heparin has given a large impulse to the rational design of heparin related drugs. De novo chemical synthesis of the corresponding pentasaccharide as well as simplified a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e6e79ccd1d36af2e25f70c56617a07
https://doi.org/10.1160/th09-01-0063

Characterization of a cell-wall acid phosphatase (PhoAp) in Aspergillus fumigatus The GenBank accession number for the A. fumigatus PHOA sequence reported in this paper is AF462065

Autor: Jean-Paul Latgé, Muriel Bernard, Claus Crone Fuglsang, Constantinos E. Vorgias, J P Debeaupuis, Isabelle Mouyna, Thierry Fontaine, Guy Dubreucq

Publikováno v: Microbiology. 148:2819-2829

In the filamentous fungus Aspergillus fumigatus, the vast majority of the cell-wall-associated proteins are secreted proteins that are in transit in the cell wall. These proteins can be solubilized by detergents and reducing agents. Incubation of a S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d47e9215a2a42076bba08199071b2c9f
https://doi.org/10.1099/00221287-148-9-2819

Enhancement of PDGF-BB mitogenic activity on human dermal fibroblasts by biospecific dextran derivatives

Autor: Barbara Vanhoecke, Latifa Dahri-Correia, Jean-Claude Michalski, Jose Correia, Jérôme Lemoine, Christelle Rigaut, Guy Dubreucq, Marc Bracke, Anne-Sophie Vercoutter-Edouart, François Renaux

Publikováno v: Biomaterials
Biomaterials, Elsevier, 2008, 29 (14), pp.2280-2292. ⟨10.1016/j.biomaterials.2008.01.020⟩
Biomaterials, 2008, 29 (14), pp.2280-2292. ⟨10.1016/j.biomaterials.2008.01.020⟩

Dextran derivatives are biosynthetic polyanionic polymers which exert some of the heparin properties such as regulating the activity of several heparin-binding growth factors. Based on a reproducible synthetic procedure, we have synthesized a new gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8a8bc2e4cd802a00d4289a2aa3bf5e
https://hal.archives-ouvertes.fr/hal-00315654

Polysaccharide microarrays for polysaccharide-platelet-derived-growth-factor interaction studies

Autor: Latifa Dahri-Correia, Jose Correia, Oleg Melnyk, Guy Dubreucq, Olivier Carion, Julien Lefebvre

Publikováno v: Chembiochem : a European journal of chemical biology. 7(5)

Polysaccharide microarrays have great potential for the high-throughput analysis of polysaccharide-protein interactions. Here we demonstrate that a polysaccharide microarray prepared by printing a library of dextran polymers derivatized by methylcarb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5decf18ad3320863c921a0f9fcb45bfa
https://pubmed.ncbi.nlm.nih.gov/16550626