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pro vyhledávání: '"Guy Dodson"'
The structure of the T-lymphocyte cell surface glycoprotein CD4 is of considerable biological and medical interest. Recombinant rat CD4 expressed in soluble form in mammalian cells and complexed with W3/25 monoclonal Fab fragments formed crystals tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ad3f4a1769e16505cce8307f70ea09
https://doi.org/10.1016/s0022-2836(05)80116-0
https://doi.org/10.1016/s0022-2836(05)80116-0
Autor:
Guy Dodson
Publikováno v:
Biochemical Society Transactions. 39:1313-1322
Scientific contact lies at the heart of research and that between China and the U.K. is an important example of how it can come about. In 1911, when the Biochemical Society began, U.K. science was developing fast with profound discoveries in physics
Autor:
Lenka Zakova, Johan P. Turkenburg, Jiri Jiracek, Guy Dodson, Christopher J. Watson, Emília Antolíková, Andrzej M. Brzozowski
Publikováno v:
Proceedings of the National Academy of Sciences. 107:1966-1970
Insulin is a key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism. Insulin action is manifested through binding of its monomeric form to the Insulin Receptor (IR). At present, howeve
Publikováno v:
EMBO reports. 9:144-150
Recent advances in computer hardware and software have led to the development of increasingly successful molecular simulations of protein structural dynamics that are intrinsic to biological processes. These simulations have resulted in models that i
Publikováno v:
IUBMB Life. 59:118-125
Conformational transitions and functional stability of the bile salt hydrolase (BSH; cholylglycine EC: 3.5.1.24) from Bifidobacterium longum (BlBSH) cloned and expressed in E. coli were studied under thermal, chemical and pH-mediated denaturation con
Autor:
Cheravakkattu G. Suresh, Guy Dodson, Archana Pundle, R. Suresh Kumar, Eleanor J. Dodson, James A. Brannigan, Asmita Prabhune
Publikováno v:
Journal of Biological Chemistry. 281:32516-32525
Bile salt hydrolase (BSH) is an enzyme produced by the intestinal microflora that catalyzes the deconjugation of glycine- or taurine-linked bile salts. The crystal structure of BSH reported here from Bifidobacterium longum reveals that it is a member
Autor:
Jens Brange, Johan P. Turkenburg, Zhang Youshang, Lenka Zakova, Jean L. Whittingham, Guy Dodson, Eleanor J. Dodson
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 62:505-511
Despentapeptide (des-B26-B30) insulin (DPI), an active modified insulin, has been crystallized in the presence of 20% acetic acid pH 2. A crystal structure analysis to 1.8 A spacing (space group I222) revealed that the DPI molecule, which is unable t
Autor:
Guy Dodson
Publikováno v:
The Biochemist. 27:31-35
Fred Sanger is a biochemist who practised chemistry and whose discoveries have been fundamental to the development of modern biological science. His insights into sequencing methods and the central roles played by proteins and nucleic acids in the mo
Autor:
James A. Brannigan, Cheravakkattu G. Suresh, Archana Pundle, P.M. Chandra, Guy Dodson, Asmita Prabhune, Johan P. Turkenburg
Publikováno v:
Europe PubMed Central
The crystallization of three catalytically inactive mutants of penicillin V acylase (PVA) from Bacillus sphaericus in precursor and processed forms is reported. The mutant proteins crystallize in different primitive monoclinic space groups that are d
Publikováno v:
Microscopy Research and Technique. 60:581-592
S100A12 is a member of the S100 family of EF-hand calcium-binding proteins. Together with two other calgranulins, S100A8 and S100A9, it is mostly expressed in human granulocytes, although there is increasing evidence of expression in keratinocytes an