Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Guy Casy"'
1
Synthesis and Applications of HexaPHEMP, a Novel Biaryl Diphosphine Ligand
Autor: Andrew J. Wildsmith, Mark J. Burk, Julian P. Henschke, Daniela Herzberg, Christopher J. Cobley, Justine A. Peterson, Christophe G. Malan, Guy Casy
Publikováno v: Advanced Synthesis & Catalysis. 345:300-307
The novel biaryldiphosphine ligand 1 (Hexa- PHEMP) has been prepared in five steps from commercially available 3,4,5-trimethylphenol using a concise synthetic route. This approach also allows fine tuning of the ligand×s stereoelectronic properties t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ca445abba152cacdfbfeba729f7424
https://doi.org/10.1002/adsc.200390025
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2
An efficient route to all eight stereoisomers of a tri-functionalised cyclopentane scaffold for drug discovery
Autor: Nadine Derrien, Richard C. Lloyd, Raymond McCague, Mark E. B. Smith, Michael C. Lloyd, Guy Casy, Stephen Taylor, David A. Chaplin
Publikováno v: Tetrahedron: Asymmetry. 12:703-705
A route to all eight stereoisomers of 3-( tert -butoxycarbonylamino)-4-hydroxycyclopentanecarboxylic acid methyl ester is presented; these products should prove to be valuable scaffolds in pharmaceutical discovery.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c824ca85b174582fe12b3ab60f76d6ac
https://doi.org/10.1016/s0957-4166(01)00108-2
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3
ChemInform Abstract: The Use of an Altered Specificity Engineered Enzyme for Asymmetric Synthesis: Enantioselective Reduction of 4-Methyl-2-oxopent-3-enoic Acid
Autor: Guy Casy, J. John Holbrook, Richard B. Sessions, B. J. Nichols, H. Lovell, Thomas V. Lee
Publikováno v: ChemInform. 23
A genetically engineered version of Bacillus stearothermophilus lactate dehydrogenase, incorporating structural motifs which serve to alter substrate specificity in favour of α-keto acids with bulky aliphatic side chains, was used to effect enantios
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::587ae2592ccd635b69844e7ca4e6bdc9
https://doi.org/10.1002/chin.199243079
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4
ChemInform Abstract: Stereoselective Routes to Chiral 2-Hydroxy 4-Oxo Acids and Substituted 2-Hydroxybutyrolactones Using Lactate Dehydrogenases
Autor: Guy Casy
Publikováno v: ChemInform. 24
The enantioselective reduction 2,4-dioxo acids catalysed by lactate dehydrogenases provided access to 2-hydroxy-4-oxo acids of both S and R configuration. Subsequent diastereoselective chemical reduction affords 4-substituted 2-hydroxybutyrolactones.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6697296639d72c0581be7d1446090d6
https://doi.org/10.1002/chin.199326061
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7
Stereoselective routes to chiral 2-hydroxy-4-oxo acids and substituted 2-hydroxybutyrolactones using lactate dehydrogenases
Autor: Guy Casy
Publikováno v: Tetrahedron Letters. 33:8159-8162
The enantioselective reduction 2,4-dioxo acids catalysed by lactate dehydrogenases provided access to 2-hydroxy-4-oxo acids of both S and R configuration. Subsequent diastereoselective chemical reduction affords 4-substituted 2-hydroxybutyrolactones.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6cb199b109c107ad2a685e3da1a39e
https://doi.org/10.1016/s0040-4039(00)74747-2
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8
Enantioselective reduction of β,χ-unsaturated α-keto acids usingbacillus stearothermophilus lactate dehydrogenase: A new route to functionalised allylic alcohols
Autor: Thomas V. Lee, Guy Casy, Helen C. Lovell
Publikováno v: Tetrahedron Letters. 33:817-820
The enantioselective reduction of α-keto acids, catalysed by lactate dehydrogenase, has been extended bo β,χ-unsaturated substrates, providing functionalised allylic alcohols in high optical purity.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cde9a88774b7be0df330bc1a596fead
https://doi.org/10.1016/s0040-4039(00)77723-9
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9
A Simple Laboratory Procedure for Preparation of (1-Methylethenyl)oxirane (3,4-Epoxyisoprene)
Autor: Guy Casy, Janet Sherlock, Laurence M. Harwood
Publikováno v: Synthetic Communications. 20:1287-1292
This Communication describes a convenient procedure for the preparation of pure 3,4-epoxyisoprene (1). Reaction of methacrolein with the ylide prepared by reaction of trimethylsulphonium methanesulphonate with powdered sodium hydroxide suspended in d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27bae4a715b6f656a6db16b6389db24e
https://doi.org/10.1080/00397919008052839
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10
The Ramberg?Backlund Reaction
Autor: Guy Casy, Richard J. K. Taylor
Publikováno v: ChemInform. 36
The base-mediated conversion of alpha-halosulfones into region-defined alkenes was first described by Ludwig Ramberg and Birger Backlund. This transformation has proved to be of wide synthetic value and is known as the Ramberg-Backlund reaction (RBR)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd58e709776c6d29109e97c69c3db49
https://doi.org/10.1002/chin.200510293
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