Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Guy C, Brown"'
Autor:
Jacob M. Dundee, Guy C. Brown
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2024)
Abstract Neurodegenerative diseases are associated with chronic neuroinflammation in the brain, which can result in microglial phagocytosis of live synapses and neurons that may contribute to cognitive deficits and neuronal loss. The microglial P2Y6
Externí odkaz:
https://doaj.org/article/ea5995f52f0a4422a21f623cb63a9813
Autor:
Guy C. Brown, Michael T. Heneka
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Lipopolysaccharide (LPS) constitutes much of the surface of Gram-negative bacteria, and if LPS enters the human body or brain can induce inflammation and act as an endotoxin. We outline the hypothesis here that LPS may contribute to the path
Externí odkaz:
https://doaj.org/article/a186532d14ce434591744ec80c896f08
Autor:
Guy C. Brown
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The study of energy transduction in eukaryotic cells has been divided between Bioenergetics and Physiology, reflecting and contributing to a variety of Bioenergetic myths considered here: 1) ATP production = energy production, 2) energy transduction
Externí odkaz:
https://doaj.org/article/73f53501aa5543c18f6ad32ea6fe596d
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109454- (2024)
Summary: Neuropathology is often mediated by interactions between neurons and glia that cannot be modeled by monocultures. However, cocultures are difficult to use and analyze for high-content screening. Here, we perform compound screening using prim
Externí odkaz:
https://doaj.org/article/44eae0033e8c492e9622a1a2457a2b53
Autor:
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In tauopathies, abnormal deposition of intracellular tau protein followed by gradual elevation of tau in cerebrospinal fluids and neuronal loss has been documented, however, the mechanism how actually neurons die under tau pathology is large
Externí odkaz:
https://doaj.org/article/6bbc5d971c5b413b88366dc74ed4111c
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
Beta (β)-galactosidase is a lysosomal enzyme that removes terminal galactose residues from glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent cells. Microglia are brain macrophages implicated in neurodegeneratio
Externí odkaz:
https://doaj.org/article/ccb15892c4d74a9486dfd7b663a6ffd0
Autor:
Kyle M. Reid, Guy C. Brown
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1), also known as receptor associated protein (RAP), is an endoplasmic reticulum (ER) chaperone and inhibitor of LDL receptor related protein 1 (LRP1) and related receptors.
Externí odkaz:
https://doaj.org/article/c5488ff771a749c288e459ce7dc1910e
Autor:
Timothy J. Y. Birkle, Guy C. Brown
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Microglia are brain macrophages and play beneficial and/or detrimental roles in many brain pathologies because of their inflammatory and phagocytic activity. Microglial inflammation and phagocytosis are thought to be regulated by spleen tyrosine kina
Externí odkaz:
https://doaj.org/article/4aa984ed4eb44b328b24531251b9a49d
Autor:
Stefan Milde, Francesca W. van Tartwijk, Anna Vilalta, Tamara C. Hornik, Jacob M. Dundee, Mar Puigdellívol, Guy C. Brown
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-9 (2021)
Abstract Inflammation may contribute to multiple brain pathologies. One cause of inflammation is lipopolysaccharide/endotoxin (LPS), the levels of which are elevated in blood and/or brain during bacterial infections, gut dysfunction and neurodegenera
Externí odkaz:
https://doaj.org/article/890f380a8f9344229c6b9ea73e367087
Autor:
David H. Allendorf, Guy C. Brown
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neuraminidase 1 (Neu1) hydrolyses terminal sialic acid residues from glycoproteins and glycolipids, and is normally located in lysosomes, but can be released onto the surface of activated myeloid cells and microglia. We report that endotoxin/lipopoly
Externí odkaz:
https://doaj.org/article/7bc03cff0943474c9331bfa4efbf83ad