Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Guy A. Perkins"'
1
Akademický článek
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
Autor: Yi Sak Kim, Soo-Ho Choi, Keun-Young Kim, Juliana M. Navia-Pelaez, Guy A. Perkins, Seunghwan Choi, Jungsu Kim, Nicolaus Nazarenkov, Robert A. Rissman, Won-Kyu Ju, Mark H. Ellisman, Yury I. Miller
Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease. Microglia activation is accompanied by the formation and chronic expression of TLR4 inflammarafts, defined as enlarged and cholesterol-ri
Externí odkaz: https://doaj.org/article/b236636feb864e9f824fbd2a8c8f706a
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2
Akademický článek
Administration of Bicarbonate Protects Mitochondria, Rescues Retinal Ganglion Cells, and Ameliorates Visual Dysfunction Caused by Oxidative Stress
Autor: Tonking Bastola, Guy A. Perkins, Viet Anh Nguyen Huu, Saeyeon Ju, Keun-Young Kim, Ziyao Shen, Dorota Skowronska-Krawczyk, Robert N. Weinreb, Won-Kyu Ju
Publikováno v: Antioxidants, Vol 13, Iss 6, p 743 (2024)
Oxidative stress is a key factor causing mitochondrial dysfunction and retinal ganglion cell (RGC) death in glaucomatous neurodegeneration. The cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway is involved in mitochondria
Externí odkaz: https://doaj.org/article/a01e2a224885456f90b21158b33b28ac
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3
Akademický článek
Role of A-Kinase Anchoring Protein 1 in Retinal Ganglion Cells: Neurodegeneration and Neuroprotection
Autor: Tonking Bastola, Guy A. Perkins, Keun-Young Kim, Seunghwan Choi, Jin-Woo Kwon, Ziyao Shen, Stefan Strack, Won-Kyu Ju
Publikováno v: Cells, Vol 12, Iss 11, p 1539 (2023)
A-Kinase anchoring protein 1 (AKAP1) is a multifunctional mitochondrial scaffold protein that regulates mitochondrial dynamics, bioenergetics, and calcium homeostasis by anchoring several proteins, including protein kinase A, to the outer mitochondri
Externí odkaz: https://doaj.org/article/45f66093c7dc456a88f988c7ba45c70e
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4
Akademický článek
AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration
Autor: Soo-Ho Choi, Keun-Young Kim, Guy A. Perkins, Sébastien Phan, Genea Edwards, Yining Xia, Jungsu Kim, Dorota Skowronska-Krawczyk, Robert N. Weinreb, Mark H. Ellisman, Yury I. Miller, Won-Kyu Ju
Publikováno v: Redox Biology, Vol 37, Iss , Pp 101703- (2020)
Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older. Despite its high prevalence, the factors contributing to glaucoma progression are currently not well characterized. Glia-driven neuroinflammation and mitocho
Externí odkaz: https://doaj.org/article/4b43aab2eec745df953a6de55d9f1c90
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6
Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
Autor: Won-Kyu Ju, Guy A. Perkins, Keun-Young Kim, Tonking Bastola, Woo-Young Choi, Soo-Ho Choi
Publikováno v: Progress in retinal and eye research.
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their axons, resulting in vision loss. Despite its high prevalence in in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fdd8ac170d6a4aaeb23826b1d53807
https://pubmed.ncbi.nlm.nih.gov/36400670
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